2.7.1.67: 1-phosphatidylinositol 4-kinase

This is an abbreviated version!
For detailed information about 1-phosphatidylinositol 4-kinase, go to the full flat file.

Word Map on EC 2.7.1.67

2.7.1.67

4-phosphate

4,5-bisphosphate

phospholipid

phospholipase

ptdins4p

wortmannin

phosphatidylinositol-4-phosphate

pip2

5-kinase

diacylglycerol

polyphosphoinositides

ptdins4,5p2

phosphatidic

trans-golgi

gamma-32patp

1,4,5-trisphosphate

phosphatidylinositol-4,5-bisphosphate

polyoma

coxsackievirus

wortmannin-sensitive

pleckstrin

antiphosphotyrosine

oxysterol-binding

positive-sense

enteroviruses

3hinositol

ovcar-5

sensor-1

ns5a

poliovirus

medicine

pharmacology

drug development

Reaction

1-phosphatidyl-1D-myo-inositol 4-phosphate

Synonyms

1-phosphatidyl-1D-myo-inositol 4-phosphotransferase, 56 kDa type II PtdIns 4-kinase, alpha type II PI 4-kinase, AtPI4KIIIalpha1, AtPI4KIIIbeta1, AtPI4KIIIbeta2, beta type II PI 4-kinase, beta-type phosphatidylinositol 4-kinase, kinase, phosphatidylinositol (phosphorylating), Lsb6, Lsb6p, phosphatidyl-inositol 4-kinase type IIIalpha, phosphatidylinositol 4 kinase, phosphatidylinositol 4 kinase IIIbeta, phosphatidylinositol 4-kinase, phosphatidylinositol 4-kinase beta, phosphatidylinositol 4-kinase beta1, phosphatidylinositol 4-kinase IIalpha, phosphatidylinositol 4-kinase IIbeta, phosphatidylinositol 4-kinase III alpha, phosphatidylinositol 4-kinase IIIalpha, phosphatidylinositol 4-kinase IIIbeta, phosphatidylinositol 4-kinase IIIbeta,, phosphatidylinositol 4-kinase type 2-alpha, phosphatidylinositol 4-kinase type II, phosphatidylinositol 4-kinase type II alpha, phosphatidylinositol 4-kinase type IIalpha, phosphatidylinositol 4-kinase type IIbeta, phosphatidylinositol 4-kinase type-III alpha, phosphatidylinositol kinase, phosphatidylinositol-4-kinase, phosphatidylinositol-4-kinase IIalpha, phosphatidylinositol-4-kinase III beta, phosphatidylinositol-4-kinase type II alpha, phosphatidylinositol-4-kinase type IIalpha, PI 4-kinase, PI 4-kinase type IIalpha, PI kinase, PI-4 kinase, PI4-kinase, PI4K, PI4K beta, PI4K IIalpha, PI4K IIbeta, PI4K IIIbeta, PI4K2, PI4K230, PI4K2A, PI4K55, PI4K92, PI4KA, PI4KB, PI4Kbeta, PI4Kbeta1, PI4Kgamma3, PI4Kgamma5, PI4KII, PI4KIIalpha, PI4KIIbeta, PI4KIII-beta, PI4KIIIalpha, PI4KIIIbeta, Pik1, Pik1p, PIK230, Pik2p, Pik4ca, PIK4IIalpha, PIK4IIbeta, PIK4IIIalpha, PIK4IIIbeta, PIK55, PIKCB, PtdIns 4-kinase, PtdIns 4-kinase beta, PtdIns4KIIalpha, Stt4p, type II phosphatidylinositol 4-kinase, type II phosphatidylinositol kinase, type II phosphoinositide 4-kinase, type II PI 4-kinase enzyme, type II PI4Kalpha, type II PtdIns 4-kinase, type IIalpha phosphatidylinositol 4-kinase, type III alpha phosphatidylinositol 4-kinase, type III phosphatidylinositol 4-kinase alpha, type III phosphatidylinositol 4-kinase beta, type III PI 4-kinase beta, type III PI4K, type III PI4Kbeta, type-II PI4K, type-III phosphatidylinositol 4-kinase beta1, type-III phosphatidylinositol 4-kinase beta2, type-III PI4K

ECTree

2 Transferases

2.7 Transferring phosphorus-containing groups

2.7.1 Phosphotransferases with an alcohol group as acceptor

2.7.1.67 1-phosphatidylinositol 4-kinase

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Results	in table
70	Activating Compound
10362	AA Sequence
3	Application
1	CAS Registry Number
33	Cloned(Commentary)
31	Cofactor
5	Crystallization (Commentary)
330	Disease/ Diagnostics
3	Expression
63	General Information
1	General Stability
160	IC50 Value
470	Inhibitors
42	Ki Value [mM]
72	KM Value [mM]
166	Localization
74	Metals/Ions
49	Molecular Weight [Da]
71	Natural Substrates/ Products (Substrates)
155	Organism
4	Pathway
49	PDB ID
27	pH Optimum
14	pH Range
1	pH Stability
1	pI Value
10	Posttranslational Modification
26	Protein Variants
47	Purification (Commentary)
5	Reaction
1	Reaction Type
144	Reference
1	Renatured (Commentary)
131	Source Tissue
17	Specific Activity [micromol/min/mg]
7	Storage Stability
164	Substrates and Products (Substrate)
29	Subunits
242	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
2	Temperature Range [°C]
9	Temperature Stability [°C]
4	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 2.7.1.67 - 1-phosphatidylinositol 4-kinase

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2'-dATP + 1-phosphatidyl-1D-myo-inositol

2'-dADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

Bos taurus

641771

ADP + 1-phosphatidyl-1D-myo-inositol

AMP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

Bos taurus

12% of the activity with ATP

641787

ATP + 1-phosphatidyl-1D-myo-inositol

ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

57 entries

CTP + 1-phosphatidyl-1D-myo-inositol

CDP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

Bos taurus

10% of the activity with ATP

641787

dATP + 1-phosphatidyl-1D-myo-inositol

dADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

Bos taurus

104% of the activity with ATP

641787

GTP + 1-phosphatidyl-1D-myo-inositol

GDP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

4 entries

ITP + 1-phosphatidyl-1D-myo-inositol

IDP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

Bos taurus

11% of the activity with ATP

641787

TTP + 1-phosphatidyl-1D-myo-inositol

TDP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

Bos taurus

3% of the activity with ATP

641787

UTP + 1-phosphatidyl-1D-myo-inositol

UDP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

Bos taurus

18% of the activity with ATP

641787

additional information

8 entries