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2.7.1.67: 1-phosphatidylinositol 4-kinase

This is an abbreviated version!
For detailed information about 1-phosphatidylinositol 4-kinase, go to the full flat file.

Word Map on EC 2.7.1.67

Reaction

ATP
+
1-phosphatidyl-1D-myo-inositol
=
ADP
 +
1-phosphatidyl-1D-myo-inositol 4-phosphate

Synonyms

1-phosphatidyl-1D-myo-inositol 4-phosphotransferase, 56 kDa type II PtdIns 4-kinase, alpha type II PI 4-kinase, AtPI4KIIIalpha1, AtPI4KIIIbeta1, AtPI4KIIIbeta2, beta type II PI 4-kinase, beta-type phosphatidylinositol 4-kinase, kinase, phosphatidylinositol (phosphorylating), Lsb6, Lsb6p, phosphatidyl-inositol 4-kinase type IIIalpha, phosphatidylinositol 4 kinase, phosphatidylinositol 4 kinase IIIbeta, phosphatidylinositol 4-kinase, phosphatidylinositol 4-kinase beta, phosphatidylinositol 4-kinase beta1, phosphatidylinositol 4-kinase IIalpha, phosphatidylinositol 4-kinase IIbeta, phosphatidylinositol 4-kinase III alpha, phosphatidylinositol 4-kinase IIIalpha, phosphatidylinositol 4-kinase IIIbeta, phosphatidylinositol 4-kinase IIIbeta,, phosphatidylinositol 4-kinase type 2-alpha, phosphatidylinositol 4-kinase type II, phosphatidylinositol 4-kinase type II alpha, phosphatidylinositol 4-kinase type IIalpha, phosphatidylinositol 4-kinase type IIbeta, phosphatidylinositol 4-kinase type-III alpha, phosphatidylinositol kinase, phosphatidylinositol-4-kinase, phosphatidylinositol-4-kinase IIalpha, phosphatidylinositol-4-kinase III beta, phosphatidylinositol-4-kinase type II alpha, phosphatidylinositol-4-kinase type IIalpha, PI 4-kinase, PI 4-kinase type IIalpha, PI kinase, PI-4 kinase, PI4-kinase, PI4K, PI4K beta, PI4K IIalpha, PI4K IIbeta, PI4K IIIbeta, PI4K2, PI4K230, PI4K2A, PI4K55, PI4K92, PI4KA, PI4KB, PI4Kbeta, PI4Kbeta1, PI4Kgamma3, PI4Kgamma5, PI4KII, PI4KIIalpha, PI4KIIbeta, PI4KIII-beta, PI4KIIIalpha, PI4KIIIbeta, Pik1, Pik1p, PIK230, Pik2p, Pik4ca, PIK4IIalpha, PIK4IIbeta, PIK4IIIalpha, PIK4IIIbeta, PIK55, PIKCB, PtdIns 4-kinase, PtdIns 4-kinase beta, PtdIns4KIIalpha, Stt4p, type II phosphatidylinositol 4-kinase, type II phosphatidylinositol kinase, type II phosphoinositide 4-kinase, type II PI 4-kinase enzyme, type II PI4Kalpha, type II PtdIns 4-kinase, type IIalpha phosphatidylinositol 4-kinase, type III alpha phosphatidylinositol 4-kinase, type III phosphatidylinositol 4-kinase alpha, type III phosphatidylinositol 4-kinase beta, type III PI 4-kinase beta, type III PI4K, type III PI4Kbeta, type-II PI4K, type-III phosphatidylinositol 4-kinase beta1, type-III phosphatidylinositol 4-kinase beta2, type-III PI4K

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.67 1-phosphatidylinositol 4-kinase

IC50 Value

IC50 Value on EC 2.7.1.67 - 1-phosphatidylinositol 4-kinase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.000021
(1'R)-2'-acetyl-N-(2-fluorophenyl)-1'-(hydroxymethyl)-7'-methoxy-1',2',3',9'-tetrahydrospiro[piperidine-4,4'-pyrido[3,4-b]indole]-1-carboxamide
0.0000415
(1-((5-(6-chloro-8-(((2-ethylpyridin-4-yl)methyl)amino)-2-methylimidazo[1,2-b]pyridazin-3-yl)-2-methoxyphenyl)sulfonyl)-piperidin-4-yl)methanol
Homo sapiens
pH and temperature not specified in the publication
0.000187
(3R)-1-[3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonyl]pyrrolidin-3-ol
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.000023
(4-[5-amino-6-[4-(trifluoromethyl)phenyl]pyrazin-2-yl]phenyl)(piperazin-1-yl)methanone
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.000029
1-[3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonyl]piperidin-4-ol
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.00109
1-[3-[9-(3,4-dimethoxyphenyl)-8-methyl-6-[[2-(morpholin-4-yl)ethyl]amino]-9H-purin-2-yl]phenyl]-2-methylpropan-1-one
Homo sapiens
-
isoform PI4K IIIbeta, pH and temperature not specified in the publication
0.0000062
1-[5-(6-chloro-8-[[(2-ethylpyridin-4-yl)methyl]amino]-2-methylimidazo[1,2-b]pyridazin-3-yl)-2-methoxybenzene-1-sulfonyl]piperidin-4-ol
Homo sapiens
pH and temperature not specified in the publication
0.001
2-(4-methylpiperazin-1-yl)-8-(pyridin-4-yl)-1,5-naphthyridine
Plasmodium falciparum
-
IC50 above 0.001 mM, pH and temperature not specified in the publication
0.000084
2-([3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]phenyl]sulfonyl)ethanol
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.00012 - 0.0014
2-amino-1-(isopropylsulfonyl)-6-benzimidazole phenylketone oxime
0.001755
2-fluoro-5-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzamide
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.003668
2-[3-(benzylsulfanyl)phenyl]-8-(pyridin-4-yl)-1,5-naphthyridine
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.00091
2-[3-(methylsulfonyl)phenyl]-8-(piperazin-1-yl)-1,5-naphthyridine
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.000147
2-[3-(methylsulfonyl)phenyl]-8-(pyridin-4-yl)-1,5-naphthyridine
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.001432
2-[3-(piperidine-1-sulfonyl)phenyl]-8-(pyridin-4-yl)-1,5-naphthyridine
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.000046
2-[3-[(3R,5S)-3,5-dimethylpiperazine-1-sulfonyl]phenyl]-8-(pyridin-4-yl)-1,5-naphthyridine
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.005
2-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
Plasmodium falciparum
-
IC50 above 0.005 mM, pH and temperature not specified in the publication
0.0000035
2-[[7-(3,4-dimethoxyphenyl)quinoxalin-2-yl]amino]-N-methylacetamide
0.0000337
3-(6-chloro-2-methyl-8-[[(2-methylpyridin-4-yl)methyl]amino]imidazo[1,2-b]pyridazin-3-yl)-N,N-dimethylbenzene-1-sulfonamide
Homo sapiens
pH and temperature not specified in the publication
0.0000746 - 0.0001454
3-(6-chloro-2-methyl-8-[[(pyridin-3-yl)methyl]amino]imidazo[1,2-b]pyridazin-3-yl)-N,N-dimethylbenzene-1-sulfonamide
0.0000264
3-(6-chloro-2-methyl-8-[[(pyridin-4-yl)methyl]amino]imidazo[1,2-b]pyridazin-3-yl)-N,N-dimethylbenzene-1-sulfonamide
Homo sapiens
pH and temperature not specified in the publication
0.0000125
3-(6-chloro-8-[[(2-ethylpyridin-4-yl)methyl]amino]-2-methylimidazo[1,2-b]pyridazin-3-yl)-N,N-dimethylbenzene-1-sulfonamide
Homo sapiens
pH and temperature not specified in the publication
0.000719
3-(8-phenyl-1,5-naphthyridin-2-yl)benzenesulfonamide
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.000215 - 0.000277
3-[8-(1H-pyrazol-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
0.000091 - 0.000105
3-[8-(3-fluoropyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
0.000728
3-[8-(4-benzylpiperazin-1-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.000437 - 0.000727
3-[8-(4-methylpiperazin-1-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
0.000084
3-[8-(6-methylpyridin-3-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.000119 - 0.000238
3-[8-(pyridin-3-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
0.000025 - 0.000031
3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]-N-[2-(pyrrolidin-1-yl)ethyl]benzene-1-sulfonamide
0.000935
3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]aniline
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.000745
3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzamide
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.000122
3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.000063 - 0.000102
3-[8-[2-(trifluoromethyl)pyridin-4-yl]-1,5-naphthyridin-2-yl]benzenesulfonamide
0.000265
3-[8-[4-(trifluoromethyl)phenyl]-1,5-naphthyridin-2-yl]benzenesulfonamide
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.005
4-fluoro-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzamide
Plasmodium falciparum
-
IC50 above 0.005 mM, pH and temperature not specified in the publication
0.005
4-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
Plasmodium falciparum
-
IC50 above 0.005 mM, pH and temperature not specified in the publication
0.00237
4-[9-(3,4-dimethoxyphenyl)-8-methyl-6-[[2-(morpholin-4-yl)ethyl]amino]-9H-purin-2-yl]phenol
Homo sapiens
-
isoform PI4K IIIbeta, pH and temperature not specified in the publication
0.0000273
5-(6-chloro-8-[[(2-ethylpyridin-4-yl)methyl]amino]-2-methylimidazo[1,2-b]pyridazin-3-yl)-2-methoxy-N,N-dimethylbenzene-1-sulfonamide
Homo sapiens
pH and temperature not specified in the publication
0.0000172
5-(6-chloro-8-[[(2-ethylpyridin-4-yl)methyl]amino]-2-methylimidazo[1,2-b]pyridazin-3-yl)-2-methoxy-N-(2-methoxyethyl)benzene-1-sulfonamide
Homo sapiens
pH and temperature not specified in the publication
0.0000086
5-(6-chloro-8-[[(2-ethylpyridin-4-yl)methyl]amino]-2-methylimidazo[1,2-b]pyridazin-3-yl)-2-methoxy-N-(prop-2-en-1-yl)benzene-1-sulfonamide
Homo sapiens
pH and temperature not specified in the publication
0.0000053
5-(6-chloro-8-[[(2-ethylpyridin-4-yl)methyl]amino]-2-methylimidazo[1,2-b]pyridazin-3-yl)-N-(1-hydroxybutan-2-yl)-2-methoxybenzene-1-sulfonamide
Homo sapiens
pH and temperature not specified in the publication
0.0000061 - 0.0134
5-(6-chloro-8-[[(2-ethylpyridin-4-yl)methyl]amino]-2-methylimidazo[1,2-b]pyridazin-3-yl)-N-(2-hydroxyethyl)-2-methoxybenzene-1-sulfonamide
0.000056
5-(6-chloro-8-[[(2-ethylpyridin-4-yl)methyl]amino]-2-methylimidazo[1,2-b]pyridazin-3-yl)-N-cyclopropyl-2-methoxybenzene-1-sulfonamide
Homo sapiens
pH and temperature not specified in the publication
0.000009 - 0.001128
5-(6-chloro-8-[[(2-ethylpyridin-4-yl)methyl]amino]-2-methylimidazo[1,2-b]pyridazin-3-yl)-N-[2-(dimethylamino)ethyl]-2-methoxybenzene-1-sulfonamide
0.0000034
5-[4-(methylsulfonyl)phenyl]-6'-(trifluoromethyl)-3,3'-bipyridin-2-amine
0.000543
5-[8-(1H-pyrazol-4-yl)-1,5-naphthyridin-2-yl]pyridine-3-sulfonamide
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.000424
5-[8-(4-cyanophenyl)-1,5-naphthyridin-2-yl]pyridine-3-sulfonamide
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.000284 - 0.000377
5-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]pyridine-3-sulfonamide
0.000355
5-[8-[4-(trifluoromethoxy)phenyl]-1,5-naphthyridin-2-yl]pyridine-3-sulfonamide
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.000441
6-chloro-N-[(2-ethylpyridin-4-yl)methyl]-3-(4-methoxyphenyl)-2-methylimidazo[1,2-b]pyridazin-8-amine
Homo sapiens
pH and temperature not specified in the publication
0.0000191
6-chloro-N-[(2-ethylpyridin-4-yl)methyl]-3-[4-methoxy-3-(1H-pyrazole-1-sulfonyl)phenyl]-2-methylimidazo[1,2-b]pyridazin-8-amine
Homo sapiens
pH and temperature not specified in the publication
0.000176
6-chloro-N-[(2-ethylpyridin-4-yl)methyl]-3-[4-methoxy-3-(morpholine-4-sulfonyl)phenyl]-2-methylimidazo[1,2-b]pyridazin-8-amine
Homo sapiens
pH and temperature not specified in the publication
0.0000592
6-chloro-N-[(2-ethylpyridin-4-yl)methyl]-3-[4-methoxy-3-(piperidine-1-sulfonyl)phenyl]-2-methylimidazo[1,2-b]pyridazin-8-amine
Homo sapiens
pH and temperature not specified in the publication
0.001484
8-(pyridin-4-yl)-2-[3-(pyrrolidin-1-ylsulfonyl)phenyl]-1,5-naphthyridine
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.001
8-(pyridin-4-yl)-2-[5-(trifluoromethyl)pyridin-3-yl]-1,5-naphthyridine
Plasmodium falciparum
-
IC50 above 0.001 mM, pH and temperature not specified in the publication
0.0052
8-bromo-9-(3,4-dimethoxyphenyl)-2-methyl-N-[2-(morpholin-4-yl)ethyl]-9H-purin-6-amine
Homo sapiens
-
isoform PI4K IIIbeta, pH and temperature not specified in the publication
0.00091
9-(3,4-dimethoxyphenyl)-2,8-dimethyl-N-[2-(morpholin-4-yl)ethyl]-5,9-dihydro-4H-purin-6-amine
Homo sapiens
-
isoform PI4K IIIbeta, pH and temperature not specified in the publication
0.00191
9-(3,4-dimethoxyphenyl)-2-ethynyl-8-methyl-N-[2-(morpholin-4-yl)ethyl]-9H-purin-6-amine
Homo sapiens
-
isoform PI4K IIIbeta, pH and temperature not specified in the publication
0.00299
9-(3,4-dimethoxyphenyl)-2-methoxy-8-methyl-N-[2-(morpholin-4-yl)ethyl]-9H-purin-6-amine
Homo sapiens
-
isoform PI4K IIIbeta, pH and temperature not specified in the publication
0.00207
9-(3,4-dimethoxyphenyl)-8-methyl-6-[[2-(morpholin-4-yl)ethyl]amino]-9H-purine-2-carbonitrile
Homo sapiens
-
isoform PI4K IIIbeta, pH and temperature not specified in the publication
0.00161
9-(3,4-dimethoxyphenyl)-8-methyl-N-[2-(morpholin-4-yl)ethyl]-9H-purin-6-amine
Homo sapiens
-
isoform PI4K IIIbeta, pH and temperature not specified in the publication
0.00144
9-(3,4-dimethoxyphenyl)-8-methyl-N6-[2-(morpholin-4-yl)ethyl]-9H-purine-2,6-diamine
Homo sapiens
-
isoform PI4K IIIbeta, pH and temperature not specified in the publication
0.07 - 0.15
adenosine
0.12
ADP
Sus scrofa
-
IC50: 0.12 mM. 1 mM, 92% inhibition
0.0000035
BQR695
Plasmodium vivax
-
pH and temperature not specified in the publication
0.000021
BRD73842
Plasmodium vivax
-
pH and temperature not specified in the publication
0.4 - 5.6
Ca2+
0.000024
Cpd 6
Homo sapiens
-
isozyme PI4KIIIbeta, pH and temperature not specified in the publication
-
0.0000015
KDU691
Plasmodium vivax
-
pH and temperature not specified in the publication
0.05 - 0.1
Ly-294002
4
MES
Bos taurus
-
IC50: 4 mM
0.5
MgADP-
Saccharomyces cerevisiae
-
IC50: 0.5 mM
0.000054
MI14
Homo sapiens
pH and temperature not specified in the publication
0.0000034
MMV390048
Plasmodium vivax
-
pH and temperature not specified in the publication
0.001
N,N-dimethyl-8-(pyridin-4-yl)-1,5-naphthyridin-2-amine
Plasmodium falciparum
-
IC50 above 0.001 mM, pH and temperature not specified in the publication
0.0001633
N-(2-((3-(3-((1H-pyrazol-1-yl)sulfonyl)-4-methoxyphenyl)-6-chloro-2-methylimidazo[1,2-b]pyridazin-8-yl)amino)ethyl)-acetamide
Homo sapiens
pH and temperature not specified in the publication
0.0000269 - 0.00066
N-(2-((3-(3-(N-(4-aminocyclohexyl)sulfamoyl)-4-methoxyphenyl)-6-chloro-2-methylimidazo[1,2-b]pyridazin-8-yl)amino)ethyl)-acetamide
0.0000199
N-(2-((3-(3-(N-allylsulfamoyl)-4-methoxyphenyl)-6-chloro-2-methylimidazo[1,2-b]pyridazin-8-yl)amino)ethyl)acetamide
Homo sapiens
pH and temperature not specified in the publication
0.0000149 - 0.00819
N-(2-((6-chloro-3-(3-((4-(hydroxymethyl)piperidin-1-yl)sulfonyl)-4-methoxyphenyl)-2-methylimidazo[1,2-b]pyridazin-8-yl)amino)-ethyl)acetamide
0.0000024
N-(2-((6-chloro-3-(3-(N,N-dimethylsulfamoyl)-4-methoxyphenyl)-2-methylimidazo[1,2-b]pyridazin-8-yl)amino)ethyl)acetamide
Homo sapiens
pH and temperature not specified in the publication
0.00000723 - 0.01228
N-(2-((6-chloro-3-(3-(N-(1-hydroxybutan-2-yl)sulfamoyl)-4-methoxyphenyl)-2-methylimidazo[1,2-b]pyridazin-8-yl)amino)ethyl)-acetamide
0.00486 - 0.0935
N-(2-((6-chloro-3-(3-(N-(2-(dimethylamino)ethyl)sulfamoyl)-4-methoxyphenyl)-2-methylimidazo[1,2-b]pyridazin-8-yl)amino)-ethyl)acetamide
0.000022
N-(2-((6-chloro-3-(3-(N-(2-hydroxyethyl)sulfamoyl)-4-methoxyphenyl)-2-methylimidazo[1,2-b]pyridazin-8-yl)amino)ethyl)-acetamide
Homo sapiens
pH and temperature not specified in the publication
0.0001058
N-(2-((6-chloro-3-(3-(N-cyclopropylsulfamoyl)-4-methoxyphenyl)-2-methylimidazo[1,2-b]pyridazin-8-yl)amino)ethyl)acetamide
Homo sapiens
pH and temperature not specified in the publication
0.00000098 - 0.048
N-(2-((6-chloro-3-(4-methoxy-3-(morpholinosulfonyl)phenyl)-2-methylimidazo[1,2-b]pyridazin-8-yl)amino)ethyl)acetamide
0.0001348
N-(2-((6-chloro-3-(4-methoxy-3-(N-(2-methoxyethyl)sulfamoyl)-phenyl)-2-methylimidazo[1,2-b]pyridazin-8-yl)amino)ethyl)-acetamide
Homo sapiens
pH and temperature not specified in the publication
0.0001469 - 0.01707
N-(2-((6-chloro-3-(4-methoxy-3-(N-methyl-N-(2-(methylamino)-ethyl)sulfamoyl)phenyl)-2-methylimidazo[1,2-b]pyridazin-8-yl)-amino)ethyl)acetamide
0.0001894
N-(2-((6-chloro-3-(4-methoxy-3-(piperidin-1-ylsulfonyl)phenyl)-2-methylimidazo[1,2-b]pyridazin-8-yl)amino)ethyl)acetamide
Homo sapiens
pH and temperature not specified in the publication
0.000019 - 0.000022
N-(2-hydroxyethyl)-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
0.000412 - 0.000457
N-(2-hydroxyethyl)-3-[8-[4-(trifluoromethoxy)phenyl]-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
0.000708
N-(3-aminopropyl)-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.00618
N-(3-hydroxypropyl)-4-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.0000157 - 0.000553
N-(4-aminocyclohexyl)-5-(6-chloro-8-[[(2-ethylpyridin-4-yl)methyl]amino]-2-methylimidazo[1,2-b]pyridazin-3-yl)-2-methoxybenzene-1-sulfonamide
0.0000015
N-(4-chlorophenyl)-N-methyl-3-[4-(methylcarbamoyl)phenyl]imidazo[1,2-a]pyrazine-6-carboxamide
0.00012
N-(4-cyanophenyl)-N-methyl-3-[4-(trifluoromethyl)phenyl]imidazo[1,2-a]pyrazine-6-carboxamide
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.000019 - 0.0011
N-(5-[4-chloro-3-[(2-hydroxyethyl)sulfamoyl]phenyl]-4-methyl-1,3-thiazol-2-yl)acetamide
0.000031 - 0.000065
N-benzyl-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
0.001
N-cyclopropyl-8-(pyridin-4-yl)-1,5-naphthyridin-2-amine
Plasmodium falciparum
-
IC50 above 0.001 mM, pH and temperature not specified in the publication
0.001015
N-[(2S)-1-hydroxypropan-2-yl]-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzenesulfonamide
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.000203
N-[(oxetan-3-yl)methyl]-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.002623
N-[2-(dimethylamino)ethyl]-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzamide
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.00005
N-[2-(morpholin-4-yl)ethyl]-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.00136
N-[2-(piperidin-1-yl)ethyl]-3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]benzamide
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.00002 - 0.000046
N-[2-(pyrrolidin-1-yl)ethyl]-3-[8-[2-(trifluoromethyl)pyridin-4-yl]-1,5-naphthyridin-2-yl]benzene-1-sulfonamide
0.000054 - 0.1
N-[2-([6-chloro-3-[3-(dimethylsulfamoyl)phenyl]-2-methylimidazo[1,2-b]pyridazin-8-yl]amino)ethyl]acetamide
0.000496
N-[3-(methylsulfonyl)phenyl]-8-(pyridin-4-yl)-1,5-naphthyridin-2-amine
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.000087 - 0.00011
N-[3-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]phenyl]methanesulfonamide
0.00214
N-[3-[9-(3,4-dimethoxyphenyl)-8-methyl-6-[[2-(morpholin-4-yl)ethyl]amino]-9H-purin-2-yl]phenyl]acetamide
Homo sapiens
-
isoform PI4K IIIbeta, pH and temperature not specified in the publication
0.005
N-[8-(pyridin-4-yl)-1,5-naphthyridin-2-yl]methanesulfonamide
Plasmodium falciparum
-
IC50 above 0.005 mM, pH and temperature not specified in the publication
0.001 - 0.1
Phenylarsine oxide
0.004 - 0.1
quercetin
0.00045
tert-butyl N-[[8-(2-chlorophenyl)-4,5-dihydro[1,3]thiazolo[4,5-h]quinazolin-2-yl]carbamoyl]-beta-alaninate
Homo sapiens
-
isozyme PI4KIIIalpha, pH and temperature not specified in the publication
0.00005 - 0.3
Wortmannin
0.00057 - 0.0031
[5-(4-[[4-(morpholin-4-yl)phenyl]amino]quinazolin-6-yl)furan-2-yl]methanol