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2.7.1.67: 1-phosphatidylinositol 4-kinase

This is an abbreviated version!
For detailed information about 1-phosphatidylinositol 4-kinase, go to the full flat file.

Word Map on EC 2.7.1.67

Reaction

ATP
+
1-phosphatidyl-1D-myo-inositol
=
ADP
 +
1-phosphatidyl-1D-myo-inositol 4-phosphate

Synonyms

1-phosphatidyl-1D-myo-inositol 4-phosphotransferase, 56 kDa type II PtdIns 4-kinase, alpha type II PI 4-kinase, AtPI4KIIIalpha1, AtPI4KIIIbeta1, AtPI4KIIIbeta2, beta type II PI 4-kinase, beta-type phosphatidylinositol 4-kinase, kinase, phosphatidylinositol (phosphorylating), Lsb6, Lsb6p, phosphatidyl-inositol 4-kinase type IIIalpha, phosphatidylinositol 4 kinase, phosphatidylinositol 4 kinase IIIbeta, phosphatidylinositol 4-kinase, phosphatidylinositol 4-kinase beta, phosphatidylinositol 4-kinase beta1, phosphatidylinositol 4-kinase IIalpha, phosphatidylinositol 4-kinase IIbeta, phosphatidylinositol 4-kinase III alpha, phosphatidylinositol 4-kinase IIIalpha, phosphatidylinositol 4-kinase IIIbeta, phosphatidylinositol 4-kinase IIIbeta,, phosphatidylinositol 4-kinase type 2-alpha, phosphatidylinositol 4-kinase type II, phosphatidylinositol 4-kinase type II alpha, phosphatidylinositol 4-kinase type IIalpha, phosphatidylinositol 4-kinase type IIbeta, phosphatidylinositol 4-kinase type-III alpha, phosphatidylinositol kinase, phosphatidylinositol-4-kinase, phosphatidylinositol-4-kinase IIalpha, phosphatidylinositol-4-kinase III beta, phosphatidylinositol-4-kinase type II alpha, phosphatidylinositol-4-kinase type IIalpha, PI 4-kinase, PI 4-kinase type IIalpha, PI kinase, PI-4 kinase, PI4-kinase, PI4K, PI4K beta, PI4K IIalpha, PI4K IIbeta, PI4K IIIbeta, PI4K2, PI4K230, PI4K2A, PI4K55, PI4K92, PI4KA, PI4KB, PI4Kbeta, PI4Kbeta1, PI4Kgamma3, PI4Kgamma5, PI4KII, PI4KIIalpha, PI4KIIbeta, PI4KIII-beta, PI4KIIIalpha, PI4KIIIbeta, Pik1, Pik1p, PIK230, Pik2p, Pik4ca, PIK4IIalpha, PIK4IIbeta, PIK4IIIalpha, PIK4IIIbeta, PIK55, PIKCB, PtdIns 4-kinase, PtdIns 4-kinase beta, PtdIns4KIIalpha, Stt4p, type II phosphatidylinositol 4-kinase, type II phosphatidylinositol kinase, type II phosphoinositide 4-kinase, type II PI 4-kinase enzyme, type II PI4Kalpha, type II PtdIns 4-kinase, type IIalpha phosphatidylinositol 4-kinase, type III alpha phosphatidylinositol 4-kinase, type III phosphatidylinositol 4-kinase alpha, type III phosphatidylinositol 4-kinase beta, type III PI 4-kinase beta, type III PI4K, type III PI4Kbeta, type-II PI4K, type-III phosphatidylinositol 4-kinase beta1, type-III phosphatidylinositol 4-kinase beta2, type-III PI4K

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.67 1-phosphatidylinositol 4-kinase

Activating Compound

Activating Compound on EC 2.7.1.67 - 1-phosphatidylinositol 4-kinase

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-mercaptoethanol
-
enhances activity
2-[[(2-methoxyphenyl)methyl]amino]-2-oxoethyl 2-(furan-2-yl)quinoline-4-carboxylate
-
-
25-hydroxycholesterol
-
activates Golgi/endosome-associated PI4K activity, PI4K activation by 25-hydroxycholesterol is dependent on oxysterol binding protein, overview
3-Mercaptopropionic acid
-
enhances activity
4-[4-[(2-oxo-2,3-dihydro-1H-indol-5-yl)sulfonyl]piperazin-1-yl]benzaldehyde
-
-
4-[9-(3,4-dimethoxyphenyl)-2-methyl-6-[[2-(morpholin-4-yl)ethyl]amino]-9H-purin-8-yl]benzaldehyde
-
138% residual activity at 0.01 mM
4-[9-(3,4-dimethoxyphenyl)-2-methyl-6-[[2-(morpholin-4-yl)ethyl]amino]-9H-purin-8-yl]phenol
-
125% residual activity at 0.01 mM
9-(3,4-dimethoxyphenyl)-2,8-dimethyl-N-[2-(morpholin-4-yl)ethyl]-9H-purin-6-amine
-
126% residual activity at 0.01 mM
9-(3,4-dimethoxyphenyl)-2-methyl-N-[2-(morpholin-4-yl)ethyl]-8-(4-phenoxyphenyl)-9H-purin-6-amine
-
112% activity at 0.01 mM
amyloid beta31-34
-
fragment of amyloid beta, blocks amyloid beta1-42-induced inhibition of type II phosphatidylinositol 4-kinase activity
amyloid beta32-34
-
fragment of amyloid beta, blocks amyloid beta1-42-induced inhibition of type II phosphatidylinositol 4-kinase activity. 50% protection at around 1 nM
amyloid beta32-35
-
fragment of amyloid beta, blocks amyloid beta1-42-induced inhibition of type II phosphatidylinositol 4-kinase activity
cetyltrimethyl ammonium bromide
-
weak stimulation
Cutsum
-
stimulates
-
dichlorodiphenyltrichloroethane
-
i.e. DDT, 0.01 mM enhances activity but no changes are observed by lower concentration, membrane associated enzyme
Dimethylsulfoxide
-
1.0%, activation to 160% of the original activity
EDTA
-
2 mM, marked stimulation, even in presence of 30 mM Mg2+
eukaryotic protein translation elongation factor 1 alpha 2
-
up to a 2fold molar excess of recombinant eEF1A2 is required to maximally increase PI4KIIIbeta activity
-
FcepsilonRI
-
ross-linking activates type II phosphatidylinositol 4-kinase
-
GSH
-
enhances activity
heparin
-
0.01 mM, activation to 116% of the orginal activity
heptachlor
-
0.0001 mM enhances activity by 88%, 0.01 mM enhances activity by 52%, membrane associated enzyme
histone
-
stimulates
inosithin
-
at low concentrations
M7 analogue of mastoparan
-
0.02 mM
mastoparan
-
0.01 mM, 3-4fold increase of activity
neuronal calcium sensor 1
-
Golgi-localized isozyme PI4KIIIbeta can be activated by protein kinase D phosphorylation, and also through interactions with neuronal calcium sensor 1
-
NS5A
-
stimulates phosphatidylinositol 4-phosphate production in vivo and enhances PI4KA kinase activity in vitro, but not other viral proteins from hepatitis C virus, overview
-
octyl beta-D-glucoside
-
10-20 mM, stimulates
oxysterol binding protein
-
activates Golgi/endosome-associated PI4K activity, required for PI4K activation by 25-hydroxycholesterol, overview
-
phosvitin
-
stimulates
-
PIK-A49
-
purification of the phosphatidylinositol 4-kinase activator from carrot cells
-
poly(L-lysine)
Polyarginine
-
stimulates
RAB1
-
activates PI4KIIIalpha and stimulates the production of phosphatidylinositol 4-phosphate at the Golgi
salicylic acid
-
0.25 mM
sodium cholate
-
stimulates 3.8fold at 14 mM
sodium deoxycholate
-
stimulates
sodium taurocholate
-
weak stimulation
spermidine
-
half-maximal stimulation at 1.5 mM
spermine
Trifluoperazine
-
stimulates activity of the purified enzyme less efficiently than that of the membrane-bound enzyme
Triton X-100
Tween-20
-
weak stimulation
yeast frequenin
-
2fold increase of activity at 0.05 mM
-
[4-[9-(3,4-dimethoxyphenyl)-2-methyl-6-[[2-(morpholin-4-yl)ethyl]amino]-9H-purin-8-yl]phenyl]methanol
-
103% residual activity at 0.01 mM
additional information
-