2.7.1.66: undecaprenol kinase

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For detailed information about undecaprenol kinase, go to the full flat file.

Reaction

Synonyms

C55-isoprenoid alcohol kinase, C55-isoprenoid alcohol phosphokinase, C55-isoprenyl alcohol phosphokinase, DGKA, isoprenoid alcohol kinase, isoprenoid alcohol phosphokinase, isoprenoid-alcohol kinase, kinase (phosphorylating), isoprenoid alcohol, kinase, isoprenoid alcohol (phosphorylating), polyisoprenol kinase, UDPK, undecaprenyl phosphokinase, UOH kinase, Upk

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.1 Phosphotransferases with an alcohol group as acceptor

                2.7.1.66 undecaprenol kinase

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Results	in table
13	Activating Compound
664	AA Sequence
2	Application
1	CAS Registry Number
1	Cloned(Commentary)
3	Cofactor
5	General Information
4	General Stability
14	Inhibitors
11	KM Value [mM]
11	Localization
16	Metals/Ions
4	Molecular Weight [Da]
15	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
24	Organism
1	Pathway
4	pH Optimum
1	pH Range
8	Posttranslational Modification
24	Protein Variants
6	Purification (Commentary)
1	Reaction
1	Reaction Type
24	Reference
13	Specific Activity [micromol/min/mg]
43	Substrates and Products (Substrate)
3	Subunits
24	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
4	Temperature Stability [°C]
2	Turnover Number [1/s]

General Information

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General Information on EC 2.7.1.66 - undecaprenol kinase

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

evolution

Streptococcus mutans

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prokaryotic diacylglycerol kinase and undecaprenol kinase are the lone members of the prokaryotic diacylglycerol kinase and undecaprenol kinase family of multispan membrane enzymes that are very small, lack relationships to any other family of proteins, including water soluble kinases, and that exhibit an unusual structure and active site architecture. The enzymes show complex structure, forming domain-swapped homotrimers in which each monomer subunit has three transmembrane segments. Members of this family are unrelated to the eukaryotic diacylglycerol kinases and their prokaryotic homologs, encoded by the dgkB gene

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metabolism

Streptococcus mutans

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UDPK activity does not participate in the de novo biosynthetic pathway to undecaprenyl phosphate which does not include free undecaprenol as an intermediate

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physiological function

3 entries

physiological function

Escherichia coli

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Gram-negative Escherichia coli does not contain high llevels of free undecaprenol, thus has no need for a undecaprenol kinase

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physiological function

Bacillus subtilis

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UDPK is essential for sporulation of Bacillus subtilis

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physiological function

Streptococcus mutans

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UDPK seems to play an analogous role in Gram-positive bacteria, where its importance is evident by the fact that UDPK is essential for biofilm formation by the oral pathogen Streptococcus mutans. Undecaprenol has an unusual function as covalent transmembrane carriers of hydrophilic molecules from the inner to the outer leaflet of the plasma membrane for use in biosynthesis of molecules located in the cell wall or periplasm. UDPK is an important enzyme in Streptococcus mutans required for growth at low pH, for biosynthesis of certain lantibiotics, and for biofilm formation.. It is also a virulence factor for the formation of smooth surface dental caries

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