2.7.1.6: galactokinase
This is an abbreviated version!
For detailed information about galactokinase, go to the full flat file.
Word Map on EC 2.7.1.6
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2.7.1.6
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galactose-1-phosphate
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galactosemia
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cataract
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leloir
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uridyltransferase
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lambda
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gale
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uridyl
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thymidine
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bacteriophage
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udp-galactose
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1-phosphate
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epimerase
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lactis
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galactitol
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inborn
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udp-glucose
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kluyveromyces
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pyrophosphorylase
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gal-1-p
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presenile
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rho-dependent
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coliphage
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antitermination
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phosphomevalonate
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galactose-induced
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4'-epimerase
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glucose-1-phosphate
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counterselection
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udp-galactose-4-epimerase
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medicine
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synthesis
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nutrition
- 2.7.1.6
- galactose-1-phosphate
- galactosemia
- cataract
-
leloir
- uridyltransferase
- lambda
-
gale
-
uridyl
- thymidine
- bacteriophage
- udp-galactose
- 1-phosphate
-
epimerase
- lactis
- galactitol
-
inborn
- udp-glucose
- kluyveromyces
-
pyrophosphorylase
-
gal-1-p
-
presenile
-
rho-dependent
-
coliphage
-
antitermination
- phosphomevalonate
-
galactose-induced
-
4'-epimerase
- glucose-1-phosphate
-
counterselection
- udp-galactose-4-epimerase
- medicine
- synthesis
- nutrition
Reaction
Synonyms
atgalk, ATP:D-galactose-1-phosphotransferase, BiGalK, CLB.507001.110, CLB.510667.120, GAL1, Gal1p, galactokinase, galactokinase 1, galactose kinase, GALK, GALK1, GalKAmu, GalKSpe4, kinase (phosphorylating), galacto-, kinase, galacto- (phosphorylating), SCO3136
ECTree
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Reaction
Reaction on EC 2.7.1.6 - galactokinase
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the most likely kinetic mechanism is an ordered ternary complex in which ATP is the first substrate to bind
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ATP + alpha-D-galactose = ADP + alpha-D-galactose 1-phosphate
mechanism of D-galactose and nucleotide binding
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ATP + alpha-D-galactose = ADP + alpha-D-galactose 1-phosphate
mechanism of the reaction is sequential in both directions. Residue Asp183 acts as a catalytic base that deprotonates the C1 hydroxyl group of galactose. The pH-kcat profile of the synthesis of galactose 1-phosphate has a pKa of 6.9 likely due to Asp183. The pH-kcat/KGal profile of the reverse reaction lacks a key pKa required for a direct proton transfer mechanism. Arg36 may lower the pKa of the C1 hydroxyl to facilitate deprotonation
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