2.7.1.6: galactokinase
This is an abbreviated version!
For detailed information about galactokinase, go to the full flat file.
Word Map on EC 2.7.1.6
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2.7.1.6
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galactose-1-phosphate
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galactosemia
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cataract
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leloir
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uridyltransferase
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lambda
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gale
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uridyl
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thymidine
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bacteriophage
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udp-galactose
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1-phosphate
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epimerase
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lactis
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galactitol
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inborn
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udp-glucose
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kluyveromyces
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pyrophosphorylase
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gal-1-p
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presenile
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rho-dependent
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coliphage
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antitermination
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phosphomevalonate
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galactose-induced
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4'-epimerase
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glucose-1-phosphate
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counterselection
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udp-galactose-4-epimerase
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medicine
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synthesis
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nutrition
- 2.7.1.6
- galactose-1-phosphate
- galactosemia
- cataract
-
leloir
- uridyltransferase
- lambda
-
gale
-
uridyl
- thymidine
- bacteriophage
- udp-galactose
- 1-phosphate
-
epimerase
- lactis
- galactitol
-
inborn
- udp-glucose
- kluyveromyces
-
pyrophosphorylase
-
gal-1-p
-
presenile
-
rho-dependent
-
coliphage
-
antitermination
- phosphomevalonate
-
galactose-induced
-
4'-epimerase
- glucose-1-phosphate
-
counterselection
- udp-galactose-4-epimerase
- medicine
- synthesis
- nutrition
Reaction
Synonyms
atgalk, ATP:D-galactose-1-phosphotransferase, BiGalK, CLB.507001.110, CLB.510667.120, GAL1, Gal1p, galactokinase, galactokinase 1, galactose kinase, GALK, GALK1, GalKAmu, GalKSpe4, kinase (phosphorylating), galacto-, kinase, galacto- (phosphorylating), SCO3136
ECTree
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Inhibitors
Inhibitors on EC 2.7.1.6 - galactokinase
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2-(1,3-benzoxazol-2-ylamino)-4-(4-chloro-1H-pyrazol-3-yl)-4,6,7,8-tetrahydroquinazolin-5(1H)-one
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inhibitory to isoform Galk1, no inhibition of isoform Galk2 up to 40 microM. Uncompetitive with respect to galactose, compound directly competes with ATP at the binding site, and galactose may be required to bind first. Compound is able to lower galactose 1-phosphate levels in primary fibroblasts of patients suffering Classic Galactosemia without significant effect on viability of cells
NaCl
50500 mM, the enzymatic activity decreases approximately 40%60%, respectively; 50500 mM, the enzymatic activity decreases approximately 40%60%, respectively
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competitive with respect to ATP, uncompetitive with respect to galactose
alpha-D-galactose 1-phosphate
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uncompetitive inhibitor with respect to galactose, mixed inhibitor with respect to ATP
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0.5 mM HgCl2, complete inhibition, activity is completely restored by 1 mM dithiothreitol
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0.1 mM, complete inhibition, activity is completely restored by 1 mM dithiothreitol
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not inhibitory: N-acetyl-D-galactosamine, L-arabinose, D-fucose, D-glucose
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additional information
discovery of novel inhibitors of human galactokinase by high-throughput structure-based virtual screening
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additional information
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discovery of novel inhibitors of human galactokinase by high-throughput structure-based virtual screening
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additional information
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Hg-containing compounds at 0.4 mM completely block the enzyme
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