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2.7.1.6: galactokinase

This is an abbreviated version!
For detailed information about galactokinase, go to the full flat file.

Word Map on EC 2.7.1.6

Reaction

ATP
+
alpha-D-galactose
=
ADP
+
alpha-D-galactose 1-phosphate

Synonyms

atgalk, ATP:D-galactose-1-phosphotransferase, BiGalK, CLB.507001.110, CLB.510667.120, GAL1, Gal1p, galactokinase, galactokinase 1, galactose kinase, GALK, GALK1, GalKAmu, GalKSpe4, kinase (phosphorylating), galacto-, kinase, galacto- (phosphorylating), SCO3136

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.6 galactokinase

Inhibitors

Inhibitors on EC 2.7.1.6 - galactokinase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-(1,3-benzoxazol-2-ylamino)-4-(4-chloro-1H-pyrazol-3-yl)-4,6,7,8-tetrahydroquinazolin-5(1H)-one
-
inhibitory to isoform Galk1, no inhibition of isoform Galk2 up to 40 microM. Uncompetitive with respect to galactose, compound directly competes with ATP at the binding site, and galactose may be required to bind first. Compound is able to lower galactose 1-phosphate levels in primary fibroblasts of patients suffering Classic Galactosemia without significant effect on viability of cells
3-mercaptoethanol
-
-
adenosine-5'-[gamma-thio]triphosphate
-
-
alpha-D-galactose 1-phosphate
amikacin
-
-
ATP
isoform GalK2; isoform GalK2
bromo alpha-D-galactopyranoside
-
-
D-galactose 1-phosphate
fluoro alpha-D-galactopyranoside
-
-
galactose
-
above 1 mM
galactose-1-phosphate
-
-
genistein
-
-
gentamycin
-
-
iodoacetamide
-
0.05 mM, complete inactivation
kanamycin A
-
-
Mg2+
-
free Mg2+ is a competitive inhibitor of MgATP2-
NaCl
50–500 mM, the enzymatic activity decreases approximately 40%–60%, respectively; 50–500 mM, the enzymatic activity decreases approximately 40%–60%, respectively
neomycin
-
-
paromycin
-
-
quercetin
-
-
tobramycin
-
-
additional information
-