2.7.1.59: N-acetylglucosamine kinase
This is an abbreviated version!
For detailed information about N-acetylglucosamine kinase, go to the full flat file.
Word Map on EC 2.7.1.59
-
2.7.1.59
-
albicans
-
n-acetylmannosamine
-
hexokinases
-
glcnac-6-phosphate
-
glucosamine-6-phosphate
-
aminosugars
-
udp-n-acetylglucosamine
-
udp-glcnac
-
dynlrb1
-
n-acetylneuraminic
-
dynein
-
roadblock
-
mannac
-
2-epimerase
-
analysis
- 2.7.1.59
- albicans
- n-acetylmannosamine
- hexokinases
-
glcnac-6-phosphate
- glucosamine-6-phosphate
-
aminosugars
- udp-n-acetylglucosamine
- udp-glcnac
-
dynlrb1
-
n-acetylneuraminic
- dynein
-
roadblock
- mannac
-
2-epimerase
- analysis
Reaction
Synonyms
2-acetylamino-2-deoxy-D-glucose kinase, acetylaminodeoxyglucokinase, acetylglucosamine kinase(phosphorylating), ATP:2-acetylamino-2-deoxy-D-glucose 6-phosphotransferase, CaNag5p, GlcNAc kinase, GlcNAc-kinase, GNK, Hxk1, MurK, N-acetyl-D-glucosamine kinase, N-acetylglucosamine kinase, N-acetylmuramic acid/N-acetylglucosamine kinase, NAG5, NAGA kinase, NagK
ECTree
2.7.1.59 N-acetylglucosamine kinaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 2.7.1.59 - N-acetylglucosamine kinase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + N-acetyl-D-galactosamine
ADP + N-acetyl-D-galactosamine 6-phosphate
-
-
-
-
?
CTP + N-acetyl-D-glucosamine
CDP + N-acetyl-D-glucosamine 6-phosphate
-
-
-
-
?
dATP + N-acetyl-D-glucosamine
dADP + N-acetyl-D-glucosamine 6-phosphate
-
-
-
-
?
GTP + N-acetyl-D-glucosamine
GDP + N-acetyl-D-glucosamine 6-phosphate
-
30% of the activity with ATP
-
-
?
ITP + N-acetyl-D-glucosamine
IDP + N-acetyl-D-glucosamine 6-phosphate
-
75% of the activity with ATP
-
-
?
N-acetylglucosamine + ATP
N-acetylglucosamine 6-phosphate + ADP
-
predominantely beta-N-acetylglucosamine 6-phosphate
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
15% of the rate with N-acetyl-D-glucosamine
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
21% of the activity with N-acetyl-D-glucosamine
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
very poor substrate, 4.5% of the rate with N-acetyl-D-glucosamine
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
at equal rate than N-acetyl-D-glucosamine
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
at equal rate than N-acetyl-D-glucosamine
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
14% activity compared to N-acetyl-D-glucosamine
-
-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
-
14% activity compared to N-acetyl-D-glucosamine
-
-
?
ATP + D-mannose
ADP + D-mannose 6-phosphate
-
5% activity compared to N-acetyl-D-glucosamine
-
-
?
ATP + D-mannose
ADP + D-mannose 6-phosphate
-
5% activity compared to N-acetyl-D-glucosamine
-
-
?
ATP + N-acetyl-D-glucosamine
ADP + N-acetyl-D-glucosamine 6-phosphate
-
-
-
-
?
ATP + N-acetyl-D-glucosamine
ADP + N-acetyl-D-glucosamine 6-phosphate
-
highly specific for this substrate
-
-
?
ATP + N-acetyl-D-glucosamine
ADP + N-acetyl-D-glucosamine 6-phosphate
-
-
-
-
?
ATP + N-acetyl-D-glucosamine
ADP + N-acetyl-D-glucosamine 6-phosphate
-
-
-
-
?
ATP + N-acetyl-D-glucosamine
ADP + N-acetyl-D-glucosamine 6-phosphate
-
-
-
-
?
ATP + N-acetyl-D-glucosamine
ADP + N-acetyl-D-glucosamine 6-phosphate
-
-
-
?
ATP + N-acetyl-D-glucosamine
ADP + N-acetyl-D-glucosamine 6-phosphate
-
-
-
-
?
ATP + N-acetyl-D-glucosamine
ADP + N-acetyl-D-glucosamine 6-phosphate
Q59RG5
-
-
-
?
ATP + N-acetyl-D-glucosamine
ADP + N-acetyl-D-glucosamine 6-phosphate
-
highly specific
-
?
ATP + N-acetyl-D-glucosamine
ADP + N-acetyl-D-glucosamine 6-phosphate
-
first reaction of inducible N-acetylglucosamine catabolic pathway, enables organism to grow on N-acetylglucosamine as sole carbon source
-
?
ATP + N-acetyl-D-glucosamine
ADP + N-acetyl-D-glucosamine 6-phosphate
-
first reaction of inducible N-acetylglucosamine catabolic pathway, enables organism to grow on N-acetylglucosamine as sole carbon source
-
?
ATP + N-acetyl-D-glucosamine
ADP + N-acetyl-D-glucosamine 6-phosphate
-
-
-
?
ATP + N-acetyl-D-glucosamine
ADP + N-acetyl-D-glucosamine 6-phosphate
-
-
-
-
?
ATP + N-acetyl-D-glucosamine
ADP + N-acetyl-D-glucosamine 6-phosphate
-
-
-
?
ATP + N-acetyl-D-glucosamine
ADP + N-acetyl-D-glucosamine 6-phosphate
-
-
-
-
?
ATP + N-acetyl-D-glucosamine
ADP + N-acetyl-D-glucosamine 6-phosphate
-
enzyme is important in cell wall murein recycling, 60% of the the murein of the side wall is degraded
-
-
?
ATP + N-acetyl-D-glucosamine
ADP + N-acetyl-D-glucosamine 6-phosphate
-
-
-
?
ATP + N-acetyl-D-glucosamine
ADP + N-acetyl-D-glucosamine 6-phosphate
-
-
-
?
ATP + N-acetyl-D-glucosamine
ADP + N-acetyl-D-glucosamine 6-phosphate
-
-
-
?
ATP + N-acetyl-D-glucosamine
ADP + N-acetyl-D-glucosamine 6-phosphate
-
-
?
ATP + N-acetyl-D-glucosamine
ADP + N-acetyl-D-glucosamine 6-phosphate
-
-
-
?
ATP + N-acetyl-D-glucosamine
ADP + N-acetyl-D-glucosamine 6-phosphate
-
part of glycoprotein synthesis pathway
-
?
ATP + N-acetyl-D-glucosamine
ADP + N-acetyl-D-glucosamine 6-phosphate
-
-
-
?
ATP + N-acetyl-D-glucosamine
ADP + N-acetyl-D-glucosamine 6-phosphate
-
-
?
ATP + N-acetyl-D-glucosamine
ADP + N-acetyl-D-glucosamine 6-phosphate
-
-
-
?
ATP + N-acetyl-D-glucosamine
ADP + N-acetyl-D-glucosamine 6-phosphate
-
first enzyme of N-acetyl-D-glucosamine salvage pathway
-
?
ATP + N-acetyl-D-glucosamine
ADP + N-acetyl-D-glucosamine 6-phosphate
-
-
-
?
ATP + N-acetyl-D-glucosamine
ADP + N-acetyl-D-glucosamine 6-phosphate
-
-
-
?
ATP + N-acetyl-D-glucosamine
ADP + N-acetyl-D-glucosamine 6-phosphate
-
-
-
?
ATP + N-acetyl-D-glucosamine
ADP + N-acetyl-D-glucosamine 6-phosphate
-
-
-
?
ATP + N-acetyl-D-glucosamine
ADP + N-acetyl-D-glucosamine 6-phosphate
-
-
-
-
?
ATP + N-acetyl-D-glucosamine
ADP + N-acetyl-D-glucosamine 6-phosphate
-
-
-
?
ATP + N-acetyl-D-glucosamine
ADP + N-acetyl-D-glucosamine 6-phosphate
-
-
-
?
ATP + N-acetyl-D-glucosamine
ADP + N-acetyl-D-glucosamine 6-phosphate
-
-
-
?
ATP + N-acetyl-D-glucosamine
ADP + N-acetyl-D-glucosamine 6-phosphate
-
-
-
?
ATP + N-acetyl-D-glucosamine
ADP + N-acetyl-D-glucosamine 6-phosphate
-
highly specific
-
?
ATP + N-acetyl-D-glucosamine
ADP + N-acetyl-D-glucosamine 6-phosphate
-
involved in UDP-N-acetylglucosamine formation
-
?
ATP + N-acetyl-D-glucosamine
ADP + N-acetyl-D-glucosamine 6-phosphate
-
100% activity
-
-
?
ATP + N-acetyl-D-glucosamine
ADP + N-acetyl-D-glucosamine 6-phosphate
-
100% activity
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
roughly 50% of activity
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
recombinant enzyme, same rate as with N-acetyl-D-glucosamine
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
roughly 50% of activity
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
78% of the rate with N-acetyl-D-glucosamine
-
-
?
additional information
?
-
-
no activity with N-acetyl-D-mannose, D-mannose, D-galactose, and D-glucosamine
-
-
?
additional information
?
-
-
D-fructose, D-galactose, galactosamine, N-acetyl-D-galactosamine, mannosamine, N-acetyl-D-mannosamine do not serve as substrates
-
-
?
additional information
?
-
-
interaction of HXK1 with histone deacetylase SIR2 under filamentation inducing conditions
-
-
?
additional information
?
-
-
the enzyme has a unique specificity for both amino sugars of the bacterial cell wall, N-acetylmuramic acid and N-acetylglucosamine, which are phosphorylated at the 6-hydroxyl group, see also EC 2.7.1.170, the kcat value is 1.5fold higher for the latter substrate. Neither the non-N-acetylated forms of the cell wall sugars, i.e., glucosamine and/or muramic acid, nor epimeric hexoses or 1,6-anhydro-MurNAc are substrates for the enzyme. Product identificsation by nonradioactive and radioactive TLC
-
-
?
additional information
?
-
-
N-methyl-D-glucosamine, D-glucosamine, N-acetyl-D-galactosamine, N-acetyl-D-mannosamine do not serve as substrates, very low activities with UTP, GTP and CTP
-
-
?
additional information
?
-
-
poor activity with mannose, galactose, glucosamine, D-mannosamine, N-acetylmannosamine, and N-acetylgalactosamine
-
-
?
additional information
?
-
-
D-fructose, D-galactose, galactosamine, N-acetyl-D-galactosamine, mannosamine, N-acetyl-D-mannosamine do not serve as substrates
-
-
?
additional information
?
-
D-fructose, D-mannose, D-maltose, D-galactose, N-acetyl-D-galactosamine, ribose, fucose do not serve as substrates
-
-
?
additional information
?
-
-
D-fructose, D-mannose, D-maltose, D-galactose, N-acetyl-D-galactosamine, ribose, fucose do not serve as substrates
-
-
?
additional information
?
-
-
no activity with D-galactose and D-fructose, very low activities with N-acetyl-D-galactosamine: 7.6%, D-glucosamine: 11.2%, D-mannosamine: 2.7%, D-galactosamine: 2.1%, D-mannose: 4.5% and D-xylose: 2.1%
-
-
?
additional information
?
-
-
D-fructose, D-mannose, D-maltose, D-galactose, N-acetyl-D-galactosamine, N-acetyl-D-mannosamine do not serve as substrates
-
-
?
additional information
?
-
-
D-fructose, D-mannose, D-maltose, D-galactose, N-acetyl-D-galactosamine, N-acetyl-D-mannosamine do not serve as substrates
-
-
?
additional information
?
-
-
D-fructose, D-mannose, D-maltose, D-galactose, N-acetyl-D-galactosamine, N-acetyl-D-mannosamine do not serve as substrates
-
-
?
additional information
?
-
-
no activity with UTP, CTP, ADP or phosphoenol pyruvate
-
-
?
