2.7.1.56: 1-phosphofructokinase

This is an abbreviated version!
For detailed information about 1-phosphofructokinase, go to the full flat file.

Reaction

Synonyms

1-PFK, 1PFK, D-fructose-1-phosphate kinase, FruC, fructose 1-phosphate kinase, fructose-1-phosphate kinase, kinase, 1-phosphofructo- (phosphorylating), PFK, PFK-1, PFK1, PFK2, pfkB, phosphofructokinase 1, phosphofructokinase-1

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.1 Phosphotransferases with an alcohol group as acceptor

                2.7.1.56 1-phosphofructokinase

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Results	in table
2	Activating Compound
2524	AA Sequence
1	CAS Registry Number
2	Cloned(Commentary)
1	Cofactor
2	Expression
5	General Information
4	General Stability
42	Inhibitors
2	kcat/KM [mM/s]
3	Ki Value [mM]
25	KM Value [mM]
1	Localization
45	Metals/Ions
15	Molecular Weight [Da]
11	Natural Substrates/ Products (Substrates)
51	Organism
5	Pathway
2	PDB ID
10	pH Optimum
5	pH Range
1	pI Value
1	Protein Variants
13	Purification (Commentary)
1	Reaction
1	Reaction Type
25	Reference
9	Source Tissue
8	Specific Activity [micromol/min/mg]
9	Storage Stability
57	Substrates and Products (Substrate)
8	Subunits
26	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
1	Temperature Stability [°C]

Inhibitors

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Inhibitors on EC 2.7.1.56 - 1-phosphofructokinase

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

4-chloromercuribenzoate

Haloarcula vallismortis

-

-

727057

5,5'-dithiobis(2-nitrobenzoic acid)

Haloarcula vallismortis

-

-

727057

ADP

5 entries

ascorbate

Oryctolagus cuniculus

-

inhibition is dependent on concentration of PFK-1. No inhibition above 200 nM PFK-1. It is concluded that ascorbate inhibits PFK-1 dimer (and perhaps monomers) but not PFK-1 tetramers

688049

ATP

4 entries

citrate

Klebsiella aerogenes

-

-

640483

CTP

Clostridium pasteurianum

-

if concentration exceeds Mg2+ concentration

641681

Cu2+

Clostridium pasteurianum

-

0.5 mM, 50% inhibition in the presence of 3 mM Mg2+

641681

D-fructose 1,6-bisphosphate

3 entries

D-fructose 6-phosphate

Klebsiella aerogenes

-

-

640483

DTNB

Haloarcula vallismortis

-

-

727057

GTP

2 entries

Hg2+

Clostridium pasteurianum

-

0.002 mM, 50% inhibition in the presence of 3 mM Mg2+

641681

ITP

2 entries

K+

Oceanimonas doudoroffii

-

300 mM, activates at 30 mM

640495

LiCl

Haloarcula vallismortis

-

-

727057

MgATP2-

Homo sapiens

-

-

686728

NaCl

Oceanimonas doudoroffii

-

-

640495

NH4Cl

Haloarcula vallismortis

-

activation below 0.8 mM, inhibition above 0.8 M

727057

Ni2+

Clostridium pasteurianum

-

3 mM, 50% inhibition in the presence of 3 mM Mg2+

641681

phenylmethanesulfonyl fluoride

Escherichia coli

-

1 mM, 65% irreversible inhibition, 1.5 M ATP protect

641683

SO42-

3 entries

UTP

Clostridium pasteurianum

-

if concentration exceeds Mg2+ concentration

641681

additional information

6 entries

-

ADP

Clostridium pasteurianum

-

competitive vs. ATP

641681

ADP

Escherichia coli

-

kinetics

641683

ADP

Haloarcula vallismortis

-

competitive

727057

ADP

Oceanimonas doudoroffii

-

ATP reverses

640495

ADP

Pseudomonas putida

-

2 mM, 45% inhibition, 5 mM ATP completely relieves inhibition

641685

ATP

Clostridium pasteurianum

-

-

641681

ATP

Klebsiella aerogenes

-

additional Mg2+ reverses; at a Mg2+/ATP ratio below 2

640483

ATP

Oceanimonas doudoroffii

-

at a Mg2+/ATP ratio below 2; free form

640495

ATP

Pseudomonas putida

-

at a Mg2+/ATP ratio below 2; free form

641685

D-fructose 1,6-bisphosphate

Clostridium pasteurianum

-

noncompetitive vs. fructose 1-phosphate

641681

D-fructose 1,6-bisphosphate

Escherichia coli

-

kinetics

641683

D-fructose 1,6-bisphosphate

Klebsiella aerogenes

-

-

640483

GTP

Clostridium pasteurianum

-

-

641681

GTP

Klebsiella aerogenes

-

at a Mg2+/GTP ratio below 2

640483

ITP

Clostridium pasteurianum

-

-

641681

ITP

Klebsiella aerogenes

-

at a Mg2+/ITP ratio below 2

640483

SO42-

Clostridium pasteurianum

-

-

641681

SO42-

Oceanimonas doudoroffii

-

above 25 mM

640495

SO42-

Pseudomonas putida

-

-

641685

additional information

Clostridium pasteurianum

-

not inhibited by cAMP, pyruvate, phosphoenolpyruvate; not inhibited by citrate; not inhibited by D-fructose 6-phosphate; not inhibited by D-glucose 1-phosphate; not inhibited by D-glucose 6-phosphate; not inhibited by monovalent cations, glucose, ADPglucose, UDPglucose, NAD(H), NADP(H), dihydroxyacetone phosphate, glyceraldehyde 3-phosphate, 3-phosphoglycerate, CoA, acetyl-CoA, acetoacetyl-CoA; not inhibited by phosphate, AMP

641681

-

additional information

Escherichia coli

-

not inhibited by D-fructose 6-phosphate; not inhibited by D-glucose 1-phosphate; not inhibited by D-glucose 6-phosphate

641683

-

additional information

Klebsiella aerogenes

-

not inhibited by ATP; not inhibited by D-glucose 1-phosphate; not inhibited by D-glucose 6-phosphate; not inhibited by nucleoside monophosphates or diphosphates, D-mannose 6-phosphate, D-fructose, L-fructose 1-phosphate; not inhibited by phosphate, AMP

640483

-

additional information

Oceanimonas doudoroffii

-

not inhibited by cAMP, pyruvate, phosphoenolpyruvate; not inhibited by citrate; not inhibited by CTP and UTP; not inhibited by D-fructose 6-phosphate; not inhibited by L-glutamate; not inhibited by phosphate, AMP

640495

-

additional information

Pseudomonas putida

-

not inhibited by 6-phosphogluconate, 2-oxo-3-deoxy-6-phosphogluconate; not inhibited by cAMP, pyruvate, phosphoenolpyruvate; not inhibited by citrate; not inhibited by CTP and UTP; not inhibited by D-fructose 6-phosphate; not inhibited by D-glucose 6-phosphate; not inhibited by phosphate, AMP

641685

-

additional information

[Clostridium] symbiosum

-

not inhibited by D-fructose 6-phosphate; not inhibited by sorbose 1-phosphate

641679

-