2.7.1.35: pyridoxal kinase
This is an abbreviated version!
For detailed information about pyridoxal kinase, go to the full flat file.
Word Map on EC 2.7.1.35
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2.7.1.35
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5'-phosphate
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vitamers
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pyridoxal-5'-phosphate
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plp-dependent
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4-pyridoxic
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ribokinase
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agriculture
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synthesis
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drug development
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medicine
- 2.7.1.35
- 5'-phosphate
-
vitamers
- pyridoxal-5'-phosphate
-
plp-dependent
-
4-pyridoxic
- ribokinase
- agriculture
- synthesis
- drug development
- medicine
Reaction
Synonyms
ePL kinase, ePL kinase 1, hPL kinase, HPLK, kinase (phosphorylating), pyridoxal, kinase, pyridoxal (phosphorylating), LdPdxK, PdxK, pdxY, PKH, PL kinase, PLK, Plk1, PM kinase, PN kinase, PN/PL/PM kinase, pyridoxal 5-phosphate-kinase, pyridoxal kinase, pyridoxal kinase 1, pyridoxal kinase PKL, pyridoxal kinase-like protein SOS4, pyridoxal phosphokinase, pyridoxal/pyridoxine kinase, pyridoxamine kinase, pyridoxine kinase, pyridoxine/pyridoxal/pyridoxamine kinase, salt overly sensitive4, SAV0580, Sos4, StPLK, vitamin B6 kinase
ECTree
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Subunits
Subunits on EC 2.7.1.35 - pyridoxal kinase
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dimer
homodimer
monomer
additional information
dimer
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2 * 57200, calculated from the deduced amino acid sequence, 2 * 58000, SDS-PAGE, native mass by gel filtration
homodimer
PDXK is a dimer of two identical monomers. Each subunit is made by 9 alpha-helices and 11 beta-strands that form a central beta-sheet flanked by helices on both sides. Asp87 is placed on the C-terminal end of an active site loop connecting alpha3 helix and strand beta4, which plays a crucial role in substrate binding. Tyr84, which is part of this loop, directly interacts with the B6 vitamer substrate stacking to its pyridine ring, see for PDB ID 3KEU
native LdPdxK enzyme exhibits 43.3% alpha-helix, 24.8% beta-sheet, 0% turn, and 31.9% random coil content
additional information
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native LdPdxK enzyme exhibits 43.3% alpha-helix, 24.8% beta-sheet, 0% turn, and 31.9% random coil content
additional information
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native LdPdxK enzyme exhibits 43.3% alpha-helix, 24.8% beta-sheet, 0% turn, and 31.9% random coil content
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