2.7.1.33: pantothenate kinase
This is an abbreviated version!
For detailed information about pantothenate kinase, go to the full flat file.
Word Map on EC 2.7.1.33
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2.7.1.33
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neurodegeneration
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kinase-associated
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panks
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sign
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dystonia
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ganglia
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hallervorden-spatz
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extrapyramidal
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parkinsonism
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eye-of-the-tiger
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pla2g6
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phosphopantothenate
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dysarthria
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tiger
-
neuroaxonal
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phosphopantetheine
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hypointensity
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medicine
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4'-phosphopantothenate
-
pigmentary
-
pantothenamide
-
bradykinesia
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synthesis
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atp13a2
-
4'-phosphopantetheine
-
pantethine
-
drug development
-
neuroferritinopathy
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choreoathetosis
-
phosphopantothenoylcysteine
- 2.7.1.33
- neurodegeneration
-
kinase-associated
-
panks
- sign
- dystonia
- ganglia
- hallervorden-spatz
-
extrapyramidal
- parkinsonism
-
eye-of-the-tiger
- pla2g6
- phosphopantothenate
- dysarthria
- tiger
-
neuroaxonal
- phosphopantetheine
-
hypointensity
- medicine
- 4'-phosphopantothenate
-
pigmentary
- pantothenamide
-
bradykinesia
- synthesis
-
atp13a2
- 4'-phosphopantetheine
- pantethine
- drug development
-
neuroferritinopathy
-
choreoathetosis
-
phosphopantothenoylcysteine
Reaction
Synonyms
4-phosphopantoate, BaPanK, Cab1, Cab1p, CoaA, coaW, CoaX, D-pantothenate kinase, EhPAnK, fumble, hPanK, hPanK1, hPANK2, hPanK3, hPanK4, HpPanK-III, HsPANK3, HsPANK4, kinase, pantothenate (phosphorylating), More, mPank, mPank1, mPanK2, mPanK3, MtCoaA, MtPanK, PAK, PanK, PanK-III, PanK1, PanK1alpha, PanK1b, PanK2, PanK3, PanK4, PanKBa, pantothenate kinase, pantothenate kinase 1, pantothenate kinase 2, pantothenate kinase 3, pantothenate kinase 4, pantothenate kinase-2, pantothenic acid kinase, PfPanK, Pfpank1, PoK, rPanK4, Rts protein
ECTree
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Substrates Products
Substrates Products on EC 2.7.1.33 - pantothenate kinase
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REACTION DIAGRAM
ATP + (2E)-3-[[(2R)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]prop-2-enoic acid
ADP + 4'-phospho-CJ-15,801
CJ-15,801, the compound is phosphorylated by pantothenate kinase (PanK). Subsequently, phospho-CJ-15,801 is accepted as a substrate by the next enzyme in the pathway (phosphopantothenoylcysteine synthetase, PPCS), and reacts to become cytidylylated. The cytidylylated phospho-CJ-15,801, which closely mimics the natural reaction intermediate and binds tightly and reversibly to the enzyme, does not react further and instead inhibits the enzyme
-
-
?
ATP + (2R)-2,4-dihydroxy-3,3-dimethyl-N-(3-oxo-3-[[(piperidin-4-yl)methyl]amino]propyl)butanamide
ADP + (3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[(3-oxo-3-[[(piperidin-4-yl)methyl]amino]propyl)amino]butyl dihydrogen phosphate
-
-
-
?
ATP + (2R)-2,4-dihydroxy-3,3-dimethyl-N-(3-oxo-3-[[2-(piperazin-1-yl)ethyl]amino]propyl)butanamide
ADP + (3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[(3-oxo-3-[[2-(piperazin-1-yl)ethyl]amino]propyl)amino]butyl dihydrogen phosphate
-
-
-
?
ATP + (2R)-2,4-dihydroxy-3,3-dimethyl-N-(3-oxo-3-[[2-(pyridin-2-yl)ethyl]amino]propyl)butanamide
ADP + (3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[(3-oxo-3-[[2-(pyridin-2-yl)ethyl]amino]propyl)amino]butyl dihydrogen phosphate
-
-
-
?
ATP + (2R)-2,4-dihydroxy-3,3-dimethyl-N-(3-[[2-oxo-2-(pentylamino)ethyl]amino]propyl)butanamide
ADP + N2-(3-[[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]amino]propyl)-N-pentylglycinamide
-
-
-
?
ATP + (2R)-2,4-dihydroxy-3,3-dimethyl-N-(3-[[3-(morpholin-4-yl)propyl]amino]-3-oxopropyl)butanamide
ADP + (3R)-3-hydroxy-2,2-dimethyl-4-[(3-[[3-(morpholin-4-yl)propyl]amino]-3-oxopropyl)amino]-4-oxobutyl dihydrogen phosphate
-
-
-
?
ATP + (2R)-2,4-dihydroxy-3,3-dimethyl-N-[(1-pentyl-1H-1,2,3-triazol-4-yl)methyl]butanamide
ADP + (3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[[(1-pentyl-1H-1,2,3-triazol-4-yl)methyl]amino]butyl dihydrogen phosphate
-
-
-
?
ATP + (2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-(1-propyl-1H-1,2,3-triazol-4-yl)propyl]butanamide
ADP + (3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[[3-(1-propyl-1H-1,2,3-triazol-4-yl)propyl]amino]butyl dihydrogen phosphate
-
-
-
?
ATP + (2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-(pentylamino)propyl]butanamide
ADP + N3-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-N-pentyl-beta-alaninamide
-
-
-
?
ATP + (2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-(phenylamino)propyl]butanamide
ADP + N3-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-N-phenyl-beta-alaninamide
-
-
-
?
ATP + (2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-(pyrimidin-4-ylamino)propyl]butanamide
ADP + (3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-([3-oxo-3-[(pyrimidin-4-yl)amino]propyl]amino)butyl dihydrogen phosphate
-
-
-
?
ATP + (2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-[(3-phenylpropyl)amino]propyl]butanamide
ADP + N3-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-N-(3-phenylpropyl)-beta-alaninamide
-
-
-
?
ATP + (2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-[(pyridin-2-ylmethyl)amino]propyl]butanamide
ADP + (3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[(3-oxo-3-[[(pyridin-2-yl)methyl]amino]propyl)amino]butyl dihydrogen phosphate
-
-
-
?
ATP + (2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-[(pyridin-3-ylmethyl)amino]propyl]butanamide
ADP + (3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[(3-oxo-3-[[(pyridin-3-yl)methyl]amino]propyl)amino]butyl dihydrogen phosphate
-
-
-
?
ATP + (2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-[(pyridin-4-ylmethyl)amino]propyl]butanamide
ADP + (3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[(3-oxo-3-[[(pyridin-4-yl)methyl]amino]propyl)amino]butyl dihydrogen phosphate
-
-
-
?
ATP + (2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-[(3-methylpyridin-2-yl)amino]-3-oxopropyl]butanamide
ADP + (3R)-4-([3-[(3-aminopyridin-2-yl)amino]-3-oxopropyl]amino)-3-hydroxy-2,2-dimethyl-4-oxobutyl dihydrogen phosphate
-
-
-
?
ATP + (2R)-2,4-dihydroxy-N-(3-[[3-(1H-imidazol-1-yl)propyl]amino]-3-oxopropyl)-3,3-dimethylbutanamide
ADP + (3R)-3-hydroxy-4-[(3-[[3-(1H-imidazol-1-yl)propyl]amino]-3-oxopropyl)amino]-2,2-dimethyl-4-oxobutyl dihydrogen phosphate
-
-
-
?
ATP + (2R)-N-[3-(1,3-dihydro-2H-isoindol-2-yl)-3-oxopropyl]-2,4-dihydroxy-3,3-dimethylbutanamide
ADP + (3R)-4-[[3-(1,3-dihydro-2H-isoindol-2-yl)-3-oxopropyl]amino]-3-hydroxy-2,2-dimethyl-4-oxobutyl dihydrogen phosphate
-
-
-
?
ATP + (2R)-N-[3-(2,3-dihydro-1H-indol-1-yl)-3-oxopropyl]-2,4-dihydroxy-3,3-dimethylbutanamide
ADP + (3R)-4-[[3-(2,3-dihydro-1H-indol-1-yl)-3-oxopropyl]amino]-3-hydroxy-2,2-dimethyl-4-oxobutyl dihydrogen phosphate
-
-
-
?
ATP + (2R)-N-[3-(benzylamino)-3-oxopropyl]-2,4-dihydroxy-3,3-dimethylbutanamide
ADP + N-benzyl-N3-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alaninamide
-
-
-
?
ATP + (2R)-N-[3-[(2-butanamidoethyl)amino]-3-oxopropyl]-2,4-dihydroxy-3,3-dimethylbutanamide
ADP + N-(2-butanamidoethyl)-N3-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alaninamide
-
-
-
?
ATP + (2S)-2-hydroxy-3-(hydroxymethyl)-3-methyl-N-[3-oxo-3-(pentylamino)propyl]pentanamide
ADP + N3-[(2S,3S)-2-hydroxy-3-methyl-3-[(phosphonooxy)methyl]pentanoyl]-N-pentyl-beta-alaninamide
-
-
-
?
ATP + (2S)-3-ethyl-2-hydroxy-3-(hydroxymethyl)-N-[3-oxo-3-(pentylamino)propyl]hept-6-ynamide
ADP + N3-[(2S,3S)-3-ethyl-2-hydroxy-3-[(phosphonooxy)methyl]hept-6-ynoyl]-N-pentyl-beta-alaninamide
-
-
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?
ATP + (2S)-3-ethyl-2-hydroxy-3-(hydroxymethyl)-N-[3-oxo-3-(pentylamino)propyl]hex-5-enamide
ADP + N3-[(2S)-3-ethyl-2-hydroxy-3-[(phosphonooxy)methyl]hex-5-enoyl]-N-pentyl-beta-alaninamide
-
-
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?
ATP + (2S)-3-ethyl-2-hydroxy-3-(hydroxymethyl)-N-[3-oxo-3-(pentylamino)propyl]pentanamide
ADP + N3-[(2S)-3-ethyl-2-hydroxy-3-[(phosphonooxy)methyl]pentanoyl]-N-pentyl-beta-alaninamide
-
-
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?
ATP + (R)-4-phosphopantoate + beta-alanine
AMP + diphosphate + (R)-4'-phosphopantothenate
the enzyme is involved in coenzyme A biosynthesis in the archaea
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-
?
ATP + 3-[[(2R)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]-2-(pentylamino)propanoate
ADP + 3-[[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]amino]-2-(pentylamino)propanoate
-
-
-
?
ATP + N-alkylpantothenamides
ADP + ?
growth-inhibiting anti-metabolite, modeling into the active site structure
-
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?
ATP + N-[(2R)-2,4-dihydroxy-3,3-dimethylbutanoyl]-beta-alanyl-N-pentylglycinamide
ADP + N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl-N-pentylglycinamide
-
-
-
?
dATP + (R)-pantothenate
dADP + (R)-4'-phosphopantothenate
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-
-
?
ITP + pantothenate
IDP + D-4'-phosphopantothenate
-
phosphorylation at 46% the rate of ATP
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?
panthenoylcysteine + ATP
D-4'-phosphopanthenoylcysteine + ADP
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-
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?
pantothenyl alcohol + ATP
D-4'-phosphopantothenyl alcohol + ADP
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?
polyphosphate(n) + (R)-pantothenate
polyphosphate(n-1) + (R)-4'-phosphopantothenate
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?
UTP + pantothenate
UDP + D-4'-phosphopantothenate
-
phosphorylation at 18% the rate of ATP
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?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
-
first step in coenzyme A biosynthesis
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?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
-
coaX is essential for growth of Bacillus anthracis
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?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
-
first step in coenzyme A biosynthesis
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?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
-
the enzyme is absolutely specific for ATP, no activity with CTP, GTP, UTP, or phosphoenolpyruvate as phosphoryl donors
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?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
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-
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?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
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-
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?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
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?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
-
first step in coenzyme A biosynthesis
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?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
first step in coenzyme A biosynthesis, the enzyme has a regulatory function in the pathway
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?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
pantothenate binding site structure involving residues E249, Y262, F247, F259, Y258, and F244, located at the distal end of a large surface groove, induced fit binding mechanism, overview
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?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
first step in coenzyme A biosynthesis
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?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
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?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
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?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
-
first step in coenzyme A biosynthesis
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?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
-
the phosphate binding loop of isozyme mPanK2 is the N-terminal motif DIGGT(S)XXK
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?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
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?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
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?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
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?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
-
first step in coenzyme A biosynthesis
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?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
-
first step in coenzyme A biosynthesis, regulatory function
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?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
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-
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?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
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?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
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?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
-
first step in coenzyme A biosynthesis
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?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
-
i.e. vitamin B5
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?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
-
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-
?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
-
first step in coenzyme A biosynthesis
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-
?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
-
i.e. vitamin B5
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?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
-
-
-
?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
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?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
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?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
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?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
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?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
-
first step in coenzyme A biosynthesis
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?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
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?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
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?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
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?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
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?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
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?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
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-
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?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
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?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
A0A167Z3Z6
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?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
-
first step in coenzyme A biosynthesis
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?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
-
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?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
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?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
-
first step in coenzyme A biosynthesis
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?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
A0A167Z3Z6
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?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
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ir
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
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ir
ATP + D-pantothenate
ADP + D-4'-phosphopantothenate
-
-
-
?
ATP + D-pantothenate
ADP + D-4'-phosphopantothenate
-
poor phosphate donor: alpha,beta-methyleneadenosine 5'-triphosphate
-
?
ATP + D-pantothenate
ADP + D-4'-phosphopantothenate
-
transfers the gamma-phosphate of ATP to pantothenate
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?
ATP + D-pantothenate
ADP + D-4'-phosphopantothenate
-
first and rate-controlling reaction of CoA-biosynthesis
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?
ATP + D-pantothenate
ADP + D-4'-phosphopantothenate
-
D-configuration of 2'-hydroxyl group in pantothenate molecule is essential for functional interaction with enzyme
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?
ATP + D-pantothenate
ADP + D-4'-phosphopantothenate
-
first and rate-controlling reaction of CoA-biosynthesis
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?
ATP + D-pantothenate
ADP + D-4'-phosphopantothenate
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?
ATP + D-pantothenate
ADP + D-4'-phosphopantothenate
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?
ADP + N-heptylpantothenamide 4-phosphate
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?
ATP + N-heptylpantothenamide
ADP + N-heptylpantothenamide 4-phosphate
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?
ATP + N-heptylpantothenamide
ADP + N-heptylpantothenamide 4-phosphate
-
substrate is converted to the inactive butyldethia-CoA analogue in the further downstream pathway leading to grwoth inhibition of the organism, overview
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-
?
ATP + N-heptylpantothenamide
ADP + N-heptylpantothenamide 4-phosphate
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?
ATP + N-heptylpantothenamide
ADP + N-heptylpantothenamide 4-phosphate
-
substrate is converted to the inactive butyldethia-CoA analogue in the further downstream pathway leading to grwoth inhibition of the organism, overview
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-
?
ADP + N-nonylpantothenamide 4-phosphate
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?
ATP + N-nonylpantothenamide
ADP + N-nonylpantothenamide 4-phosphate
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?
ADP + N-pentylpantothenamide 4-phosphate
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-
-
?
ATP + N-pentylpantothenamide
ADP + N-pentylpantothenamide 4-phosphate
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-
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?
ATP + N-pentylpantothenamide
ADP + N-pentylpantothenamide 4-phosphate
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?
ATP + pantothenate
ADP + (R)-4'-phosphopantothenate
-
first step of the pathway from pantothenate to CoA. The activity of this protein is tightly regulated by CoA feedback inhibition, both in vitro and in vivo
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?
ADP + 4'-phosphopantothenate
pantothenate kinase catalyzes the first step in CoA biosynthesis
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?
ATP + pantothenate
ADP + 4'-phosphopantothenate
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?
ATP + pantothenol
ADP + 4'-phosphopantothenol
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-
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?
GTP + (R)-pantothenate
GDP + (R)-4'-phosphopantothenate
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?
GTP + (R)-pantothenate
GDP + (R)-4'-phosphopantothenate
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?
GTP + (R)-pantothenate
GDP + (R)-4'-phosphopantothenate
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?
GDP + D-4'-phosphopantothenate
-
phosphorylation at 28% the rate of ATP
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?
GTP + pantothenate
GDP + D-4'-phosphopantothenate
-
phosphorylation at 20% the rate of ATP
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?
pantothenate + ATP
phosphopantothenate + ADP
relative activity with GTP: 81%, CTP: 68%, and UTP: 91.8%
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?
?
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type III PanK in the spore-forming Bacillus anthracis plays an essential role in the novel thiol/disulfide redox biology of this category A biodefense pathogen
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?
additional information
?
-
type III PanK in the spore-forming Bacillus anthracis plays an essential role in the novel thiol/disulfide redox biology of this category A biodefense pathogen
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?
additional information
?
-
EhPanK utilizes various nucleoside triphosphates, ATP, CTP, GTP, UTP, dATP, and polyphosphates, as well as deoxynucleotides as phosphoryl donors, with ATP being the best phosphate donor
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additional information
?
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EhPanK utilizes various nucleoside triphosphates, ATP, CTP, GTP, UTP, dATP, and polyphosphates, as well as deoxynucleotides as phosphoryl donors, with ATP being the best phosphate donor
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additional information
?
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no acivity with hopantenate, formation of a pantothenate kinase-ADP-pantothenate ternary complex
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?
additional information
?
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no acivity with hopantenate, formation of a pantothenate kinase-ADP-pantothenate ternary complex
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?
additional information
?
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N-pentylpantothenate is no substrate, no activity with UTP or phosphoenolpyruvate as phosphoryl donors
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?
additional information
?
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N-pentylpantothenate is no substrate, no activity with UTP or phosphoenolpyruvate as phosphoryl donors
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additional information
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naturally occuring pantothenate kinase 2 mutant in patients with neurodegenerative disease in brain with iron accumulation, formerly termed Hallervorden-Spatz disease
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additional information
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naturally occuring pantothenate kinase 2 mutant in patients with neurodegenerative disease in brain with iron accumulation, formerly termed Hallervorden-Spatz disease
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additional information
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naturally occuring pantothenate kinase 2 mutant in patients with neurodegenerative disease in brain with iron accumulation, formerly termed Hallervorden-Spatz disease
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additional information
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miRNAs, which exist in vertebrate genomes within introns of the pantothenate kinase genes, are predicted by bioinformatics to affect multiple mRNA targets in pathways that involve cellular acetyl-CoA and lipid levels. Significantly, PANK enzymes also affect these pathways, so the miRNA and host gene may act synergistically. These predictions require experimental verification
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additional information
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pantothenate kinase is upregulated in the warming treatment
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