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2.7.1.33: pantothenate kinase

This is an abbreviated version!
For detailed information about pantothenate kinase, go to the full flat file.

Word Map on EC 2.7.1.33

Reaction

ATP
+
(R)-pantothenate
=
ADP
 +
(R)-4'-phosphopantothenate

Synonyms

4-phosphopantoate, BaPanK, Cab1, Cab1p, CoaA, coaW, CoaX, D-pantothenate kinase, EhPAnK, fumble, hPanK, hPanK1, hPANK2, hPanK3, hPanK4, HpPanK-III, HsPANK3, HsPANK4, kinase, pantothenate (phosphorylating), More, mPank, mPank1, mPanK2, mPanK3, MtCoaA, MtPanK, PAK, PanK, PanK-III, PanK1, PanK1alpha, PanK1b, PanK2, PanK3, PanK4, PanKBa, pantothenate kinase, pantothenate kinase 1, pantothenate kinase 2, pantothenate kinase 3, pantothenate kinase 4, pantothenate kinase-2, pantothenic acid kinase, PfPanK, Pfpank1, PoK, rPanK4, Rts protein , Rv1092c, TK2141, TmPanK-III, type II pantothenate kinase, type III pantothenate kinase

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.33 pantothenate kinase

KM Value

KM Value on EC 2.7.1.33 - pantothenate kinase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1
(2R)-2,4-dihydroxy-3,3-dimethyl-N-(3-oxo-3-[[(piperidin-4-yl)methyl]amino]propyl)butanamide
at pH 7.6, temperature not specified in the publication
1
(2R)-2,4-dihydroxy-3,3-dimethyl-N-(3-oxo-3-[[2-(piperazin-1-yl)ethyl]amino]propyl)butanamide
at pH 7.6, temperature not specified in the publication
0.11
(2R)-2,4-dihydroxy-3,3-dimethyl-N-(3-oxo-3-[[2-(pyridin-2-yl)ethyl]amino]propyl)butanamide
at pH 7.6, temperature not specified in the publication
1.2
(2R)-2,4-dihydroxy-3,3-dimethyl-N-(3-[[2-oxo-2-(pentylamino)ethyl]amino]propyl)butanamide
at pH 7.6, temperature not specified in the publication
0.35
(2R)-2,4-dihydroxy-3,3-dimethyl-N-(3-[[3-(morpholin-4-yl)propyl]amino]-3-oxopropyl)butanamide
at pH 7.6, temperature not specified in the publication
0.19
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[(1-pentyl-1H-1,2,3-triazol-4-yl)methyl]butanamide
at pH 7.6, temperature not specified in the publication
1
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-(1-propyl-1H-1,2,3-triazol-4-yl)propyl]butanamide
at pH 7.6, temperature not specified in the publication
0.036
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-(pentylamino)propyl]butanamide
at pH 7.6, temperature not specified in the publication
0.043
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-(phenylamino)propyl]butanamide
at pH 7.6, temperature not specified in the publication
0.45
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-(pyrimidin-4-ylamino)propyl]butanamide
at pH 7.6, temperature not specified in the publication
0.032
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-[(3-phenylpropyl)amino]propyl]butanamide
at pH 7.6, temperature not specified in the publication
0.05
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-[(pyridin-2-ylmethyl)amino]propyl]butanamide
at pH 7.6, temperature not specified in the publication
0.033
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-[(pyridin-3-ylmethyl)amino]propyl]butanamide
at pH 7.6, temperature not specified in the publication
0.13
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-[(pyridin-4-ylmethyl)amino]propyl]butanamide
at pH 7.6, temperature not specified in the publication
0.039
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-[(3-methylpyridin-2-yl)amino]-3-oxopropyl]butanamide
at pH 7.6, temperature not specified in the publication
0.022
(2R)-2,4-dihydroxy-N-(3-[[3-(1H-imidazol-1-yl)propyl]amino]-3-oxopropyl)-3,3-dimethylbutanamide
at pH 7.6, temperature not specified in the publication
0.2
(2R)-N-[3-(1,3-dihydro-2H-isoindol-2-yl)-3-oxopropyl]-2,4-dihydroxy-3,3-dimethylbutanamide
at pH 7.6, temperature not specified in the publication
0.4
(2R)-N-[3-(2,3-dihydro-1H-indol-1-yl)-3-oxopropyl]-2,4-dihydroxy-3,3-dimethylbutanamide
at pH 7.6, temperature not specified in the publication
0.067
(2R)-N-[3-(benzylamino)-3-oxopropyl]-2,4-dihydroxy-3,3-dimethylbutanamide
at pH 7.6, temperature not specified in the publication
0.24
(2R)-N-[3-[(2-butanamidoethyl)amino]-3-oxopropyl]-2,4-dihydroxy-3,3-dimethylbutanamide
at pH 7.6, temperature not specified in the publication
0.23
(2S)-2-hydroxy-3-(hydroxymethyl)-3-methyl-N-[3-oxo-3-(pentylamino)propyl]pentanamide
at pH 7.6, temperature not specified in the publication
0.11
(2S)-3-ethyl-2-hydroxy-3-(hydroxymethyl)-N-[3-oxo-3-(pentylamino)propyl]hept-6-ynamide
at pH 7.6, temperature not specified in the publication
0.59 - 1.2
(2S)-3-ethyl-2-hydroxy-3-(hydroxymethyl)-N-[3-oxo-3-(pentylamino)propyl]hex-5-enamide
0.0057 - 0.833
(R)-pantothenate
0.7
3-[[(2R)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]-2-(pentylamino)propanoate
at pH 7.6, temperature not specified in the publication
0.0031 - 9.59
ATP
1.759
CTP
-
-
0.138
dATP
-
-
0.839
dCTP
-
-
0.117
dGTP
-
-
0.723
dTTP
-
-
668
GTP
-
in citrate buffer, pH 6.5, temperature not specified in the publication
0.008 - 0.124
N-heptylpantothenamide
0.003 - 0.14
N-pentylpantothenamide
0.12
N-[(2R)-2,4-dihydroxy-3,3-dimethylbutanoyl]-beta-alanyl-N-pentylglycinamide
at pH 7.6, temperature not specified in the publication
0.06
pantheteine
at pH 7.6, temperature not specified in the publication
0.009 - 1.3
pantothenate
0.25 - 0.28
pantothenol
1.715
UTP
-
-
additional information
additional information
-