2.7.1.32: choline kinase

This is an abbreviated version!
For detailed information about choline kinase, go to the full flat file.

Reaction

Synonyms

ATP/choline phosphotransferase, ATP:choline phosphotransferase, CEK1, CEK2, CEK3, chbA, CHETK-alpha, CHK, chk-alpha, Chka, CHKA2, ChKalpha, ChoK, ChoK alpha, ChoKalpha, CHOKalpha1, ChoKalpha2, ChoKbeta1, choline kinase, choline kinase alpa, choline kinase alpha, choline kinase alpha1, choline kinase alpha2, choline kinase beta, choline kinase beta1, choline kinase isoform alpha2, choline kinase-alpha, choline phosphokinase, choline-ethanolamine kinase, choline/ethanolamine kinase, choline/ethanolamine kinase 1, choline/ethanolamine kinase 2, choline/ethanolamine kinase 3, CK, CK-alpha, CK-alpha1, CK-alpha1/beta, CK-alpha2, CK-beta, CK1, CK2, CK3, CKA-2, CKalpha, CKalpha1, CKalpha2, ckb, CKbeta, CKbeta1, CKI1, CKI1-encoded choline kinase, CKII, ER-localized Cho kinase, EtnK, hChoK, kinase, choline (phosphorylating), LicA, LinfC/EK35, More, PfChoK, PfCK, protein LicA, putative choline kinase, sChoK, TbC/EK2

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.1 Phosphotransferases with an alcohol group as acceptor

                2.7.1.32 choline kinase

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Results	in table
24	Activating Compound
207	AA Sequence
16	Application
1	CAS Registry Number
43	Cloned(Commentary)
23	Cofactor
17	Crystallization (Commentary)
647	Disease/ Diagnostics
4	Expression
51	General Information
4	General Stability
220	IC50 Value
388	Inhibitors
6	kcat/KM [mM/s]
18	Ki Value [mM]
161	KM Value [mM]
39	Localization
79	Metals/Ions
53	Molecular Weight [Da]
48	Natural Substrates/ Products (Substrates)
141	Organism
8	Pathway
54	PDB ID
34	pH Optimum
5	pH Range
2	pH Stability
6	pI Value
2	Posttranslational Modification
95	Protein Variants
41	Purification (Commentary)
23	Reaction
9	Reaction Type
132	Reference
135	Source Tissue
22	Specific Activity [micromol/min/mg]
7	Storage Stability
203	Substrates and Products (Substrate)
45	Subunits
173	Synonyms
1	Systematic Name
15	Temperature Optimum [°C]
2	Temperature Stability [°C]
49	Turnover Number [1/s]

Activating Compound

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of the Enzyme Summary Page.

Activating Compound on EC 2.7.1.32 - choline kinase

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ACTIVATING COMPOUND

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

2-Chloroethylammonium chloride

Phaseolus vulgaris

-

stimulates

641356

Acetylcholine

Rattus norvegicus

-

stimulates

641359, 641371

atropine

Phaseolus vulgaris

-

stimulates

641356

c-Src

Homo sapiens

P35790

isoform CHKA2 total cellular activity and protein levels are regulated by c-Src

723311

-

carbon tetrachloride

2 entries

Choline esters

Oryctolagus cuniculus

-

activate

641357

cysteine

Saccharomyces cerevisiae

-

omission of cysteine decreases the reaction rate by 40%

641351

epidermal growth factor receptor

Homo sapiens

P35790

isoform CHKA2 total cellular activity and protein levels are regulated by epidermal growth factor receptor. In the presence of co-transfected epidermal growth factor receptor, the activity of wild type isoform CHKA2 is increased 2.5 fold

723311

-

gibberellic acid

Phaseolus vulgaris

-

stimulates

641356

isopropyl-beta-D-thiogalactoside

Trypanosoma brucei

-

recombinant protein expression is induced with 1 mM

685011

putrescine

Rattus norvegicus

-

slight stimulation

641359, 641371

spermidine

Rattus norvegicus

-

stimulates

641359, 641371

spermine

3 entries

Zinc

Saccharomyces cerevisiae

-

intacellular zinc depletion resulted in a concentration-dependent induction of CKI1 expression

687686

additional information

2 entries

-

carbon tetrachloride

Mus musculus

O54804

CCl4, major increase in the transcript for choline kinase alpha expression in livers from mice 3 h and 6 h after administration of carbon tetrachloride. CK-beta is unaffected by the carbon tetrachloride treatment. Choline kinase activity is induced in murine livers by carbon tetrachloride as a result of an increase in the expression of the mRNA for CK-alpha and Ck-alpha protein.

685337

carbon tetrachloride

Mus musculus

O54804

CK activity is induced by carbon tetrachloride as a result of an increase in the expression of the mRNA for CK alpha and CK alpha protein. The transcriptional activity of CK alpha was markedly increased 3 h and 6 h after treatment with carbon tetrachloride. Carbon tetrachloride promotes the expression of the transcription factor activator protein 1 (AP-1) that increases CK expression and activity.

685337

spermine

Rattus norvegicus

-

stimulates

641359, 641371, 641372

spermine

Rattus norvegicus

-

required for maximal activity

641366

spermine

Rattus norvegicus

-

in presence of sufficient amounts of Mg2+

641371

additional information

Homo sapiens

-

activation of choline kinase is essential for building membranes, cell growth, cell proliferationand for rebuilding phospholipids that are degraded in the process of signal transductiony

671362

-

additional information

Homo sapiens

-

ChoKalpha mRNA levels are increased in tumour cell lines in terms of their corresponding normal human primary BEC. ChoKalpha is overexpressed with a consequent increase in phosphorylcholine production in lung-cancer cells.

688743

-