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2.7.1.30: glycerol kinase

This is an abbreviated version!
For detailed information about glycerol kinase, go to the full flat file.

Word Map on EC 2.7.1.30

Reaction

ATP
+
glycerol
=
ADP
 +
sn-glycerol 3-phosphate

Synonyms

AFUB_068560, ASTP , ATP-stimulated glucocorticoid-receptor translocation promoter , ATP: glycerol 3-phosphotransferase, ATP: glycerol-3-phosphotransferase, ATP:glycerol 3-phosphotransferase, ATP:glycerol 3-phosphotransferase , ATP:glycerol-3-phosphotransferase, GK, GK1, GK2, GK3, GK4, GK5, glcA, GLPK, glyceric kinase, glycerokinase, glycerol kinase, glycerol kinase 2, glycerol kinase 5, GLYK, GUT1, GYK, kinase, glycerol (phosphorylating), KpGlpK, More, slr1672, TbgGK, Tk-GK

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.30 glycerol kinase

Inhibitors

Inhibitors on EC 2.7.1.30 - glycerol kinase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,2-propanediol
-
-
1-Pentanol
-
-
3-Chloro-1,2-propanediol
-
-
3-Deoxy-sn-glycerol
Candida mycoderma
-
-
ATP
-
substrate inhibition
Butane-1,3-diol
Candida mycoderma
-
D- and L-configuration
Ca2+
-
inhibition by Ca2+ due to the formation of enzymatically inactive Ca-ATP complexes. The Ca2+ salt of ATP is not an appropriate substrate for glycerol kinase. Ca2+ must be removed by ion exchange pretreatment from enzyme preparations
CrATP
Candida mycoderma
-
coordination complex of Cr3+ and ATP, dead-end inhibitor
cytosolic subunit of the glucose-specific phosphotransferase system
-
allosteric inhibition
-
D-fructose 1,6-bisphosphate
-
D-fructose-1,6-bisphosphate
-
allosteric inhibition
DTNB
-
inactivation reversed by dithiothreitol
EIIAMtl
an EIIA homologue in the phosphoenolpyruvate (PEP):carbohydrate phosphotransferase system (PTS, UniProt ID A6T5D4), negatively regulates the 1,3-propanediol production in Klebsiella pneumoniae, mutational analysis, overview
-
erythritol
Candida mycoderma
-
-
ethanediol
ethanol
Candida mycoderma
-
-
fructose 1,6-bisphosphate
fructose 1,6-diphosphate
glucose
glucose 6-phosphate
glucose-specific phosphocarrier protein of the phosphoenolpyruvate:glucose phosphotransferase system
-
-
glucose-specific phosphocarrier protein of the phosphoenolpyruvate:glucose phosphotransferase system (IIA(Glc))
-
allosteric inhibitor
-
glycerol
glycerol 3-phosphate
iodoacetamide
iodoacetate
-
-
L(+)-Butane-2,3-diol
Candida mycoderma
-
-
L-alpha-glycerophosphate
-
no inhibition up to 3 mM in presence of 0.1 M glycerol
L-Threitol
Candida mycoderma
-
-
Mg2+
-
essentially required for activity, maximum activity at the optimum Mg2+ to ATP molar ratio of [0.12-0.3]. Subsequent increase of Mg2+ to ATP molar ratio higher than the values in the optimum region suppresses the enzyme activity to a non-zero asymptotic value
N-ethylmaleimide
p-chloromercuribenzoate
p-Hydroxymercuriphenylsulfonate
-
-
phosphocarrier protein IIAGlc
the unphosphorylated form of the phosphocarrier protein IIAGlc is an allosteric inhibitor of Escherichia coli glycerol kinase
-
Polyphosphate
-
addition of inorganic polyphosphate (PPin) inhibits or activates glycerol kinase due to the complexation of polyphosphate with Mg2+ that shifts Mg2+ to ATP molar ratio below or to the optimum level
Procion Blue MX-3G
-
5 mM, inactivates after a period of increased activity
propan-1-ol
propan-2-ol
Salyrganic acid
Candida mycoderma
-
-
sn-glycerol 3-phosphate
additional information
-