2.7.1.3: ketohexokinase
This is an abbreviated version!
For detailed information about ketohexokinase, go to the full flat file.
Word Map on EC 2.7.1.3
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2.7.1.3
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fructokinase
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fructose-induced
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high-fructose
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fructose-1-phosphate
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triokinase
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fructolytic
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fructosuria
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fructose-metabolizing
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medicine
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analysis
- 2.7.1.3
- fructokinase
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fructose-induced
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high-fructose
- fructose-1-phosphate
- triokinase
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fructolytic
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fructosuria
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fructose-metabolizing
- medicine
- analysis
Reaction
Synonyms
ATP:D-fructose 1-phosphotransferase, fructokinase, ketohexokinase, ketohexokinase (phosphorylating), KHK, Khk-A, Khk-C
ECTree
2.7.1.3 ketohexokinaseAdvanced search results
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Substrates Products on EC 2.7.1.3 - ketohexokinase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + D-fructose
ADP + D-fructose 1-phosphate
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specific for beta-furanose anomer
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?
ATP + D-fructose
ADP + D-fructose 1-phosphate
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except for ATP, other nucleotides such as UTP, CTP, GTP, or ITP can not act as phosphoryl donors
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?
ATP + D-fructose
ADP + D-fructose 1-phosphate
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except for ATP, other nucleotides such as UTP, CTP, GTP, or ITP can not act as phosphoryl donors
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?
ATP + D-fructose
ADP + D-fructose 1-phosphate
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fructose enters glycolytic metabolism after phosphorylation by ketohexokinase and is converted to fructose-1-phosphate. Fructose-driven glycolytic respiration in Heterocephalus glaber tissues avoids feedback inhibition of glycolysis via phosphofructokinase, allowing continued glycolytic flux independent of cellular energy status and supporting viability
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?
ATP + D-fructose
ADP + D-fructose 1-phosphate
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role in formation of glycoaldehyde
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?
ATP + D-fructose
ADP + D-fructose 1-phosphate
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conversion of fructose to glucose in liver homogenates involves the intermediary formation of D-fructose 1-phosphate
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?
additional information
?
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the minimum molecule for substrate activity seems to be (2R)-2-hydroxymethyl-3,4-dihydroxytetrahydrofuran
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?
additional information
?
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specificity of fructokinase is for a tetrahydrofuran ring with beta-D-(or alpha-L-)configuration at position 2, L-configuration at position 3 and either D- or L-configuration at position 4 and 5
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?
