2.7.1.26: riboflavin kinase
This is an abbreviated version!
For detailed information about riboflavin kinase, go to the full flat file.
Word Map on EC 2.7.1.26
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2.7.1.26
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mononucleotide
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ammoniagenes
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fadss
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isoalloxazine
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kyphoplasty
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flavocoenzyme
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flavinogenic
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ribityl
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davawensis
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roseoflavin
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famata
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ctp-dependent
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synthesis
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drug development
- 2.7.1.26
- mononucleotide
- ammoniagenes
-
fadss
- isoalloxazine
-
kyphoplasty
-
flavocoenzyme
-
flavinogenic
-
ribityl
- davawensis
- roseoflavin
- famata
-
ctp-dependent
- synthesis
- drug development
Reaction
Synonyms
AtFMN/FHy, ATP: riboflavin kinase, ATP:riboflavin kinase, bifunctional riboflavin kinase/FMN adenylyltransferase, CaFADS, FAD synthetase, FADS, FK, flavokinase, flavokinase/FAD synthetase, flavokinase/flavin adenine dinucleotide synthetase, FMN adenylyltransferase, FMNAT, HsRFK, kinase, riboflavin, More, RFK, RibC, ribF, riboflavin kinase, riboflavin kinase/FMN adenylyltransferase, riboflavine kinase, RibR
ECTree
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Inhibitors
Inhibitors on EC 2.7.1.26 - riboflavin kinase
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FAD
product inhibition, wild-type enzyme FMNAT is strongly inhibited by FAD, whereas D181A mutant enzyme has an attenuated product inhibition
product inhibition, the ADP product acts as a competitive inhibitor
ADP
product inhibition, fitted to the Lineweaver-Burk equation for competitive inhibition
Cd2+
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78% inhibition at 1 mM, effect is completely reversed by increasing concentrations of Zn2+, protection by glutathione and dithiothreitol
product inhibition. FMN is not able to bind quickly enough to inhibit the free RFK module, but it behaves as an uncompetitive inhibitor that binds to the preformed ATP-enzyme complex and forms a highly stable dead-end complex. The phosphate group at the ribityl end in the FMN product might prevent the placement and enclosure of this cofactor. The FMN product acts as an uncompetitive inhibitor
FMN
product inhibition, fitted to the Lineweaver-Burk equation for competitive inhibition
riboflavin
RF, substrate inhibition, strong inhibition is observed in the RFK activity with increased substrate concentration
a steady-state study shows the different levels and potency at which substrates and products of the RFK module inhibit its activity
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additional information
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a steady-state study shows the different levels and potency at which substrates and products of the RFK module inhibit its activity
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additional information
the inhibition mechanism of the products of the RFK reaction, FMN and ADP, kinetics, overview
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additional information
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the inhibition mechanism of the products of the RFK reaction, FMN and ADP, kinetics, overview
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