2.7.1.25: adenylyl-sulfate kinase
This is an abbreviated version!
For detailed information about adenylyl-sulfate kinase, go to the full flat file.
Word Map on EC 2.7.1.25
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2.7.1.25
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chrysogenum
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sulfate-activating
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3'-phosphate
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sulphurylase
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2.7.7.4
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brachymorphic
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cysd
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molybdolysis
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spondyloepimetaphyseal
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atp-sulphurylase
- 2.7.1.25
- chrysogenum
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sulfate-activating
- 3'-phosphate
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sulphurylase
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2.7.7.4
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brachymorphic
- cysd
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molybdolysis
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spondyloepimetaphyseal
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atp-sulphurylase
Reaction
Synonyms
3'-phosphoadenosine 5'-phosphosulfate synthetase1, 3'-phosphoadenosine-5'-phosphosulfate synthetase, 5'-phosphoadenosine sulfate kinase, adenosine 5'-phosphosulfate kinase, adenosine 5'-phosphosulphate kinase, adenosine 5-phosphosulfate kinase, adenosine 5’-phosphosulfate kinase, adenosine phosphosulfate kinase, adenosine phosphosulfokinase, adenosine-5'-phosphosulfate 3'-phosphotransferase, adenosine-5'-phosphosulfate kinase, adenosine-5'-phosphosulfate-3'-phosphokinase, adenosine-5'phosphosulfate kinase, adenosine-5’-phosphosulfate kinase, adenylyl-sulfate kinase, adenylylsulfate 3'-phosphotransferase, adenylylsulfate kinase, adenylylsulphate kinase, APK, APK1, APK2, APK3, APK4, APS kinase, APS-kinase, APSK, APSK1, ATP adenosine-5'-phosphosulfate 3'-phosphotransferase, ATP sulfurylase-APS kinase, CysC, EhAPSK, EHI_179080, kinase, adenylylsulfate (phosphorylating), MgATP:APS 3'-phosphotransferase, More, MXAN3487, MXAN_3487, MXAN_RS16905, PAPS 2, PAPS synthase, PAPS synthetase, PAPSS, PAPSS 1, PAPSS1
ECTree
2.7.1.25 adenylyl-sulfate kinaseAdvanced search results
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results (Inhibitors
Inhibitors on EC 2.7.1.25 - adenylyl-sulfate kinase
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
1-phenyl-N-[4-(pyridin-2-yl)-1,3-thiazol-2-yl]-1H-imidazole-5-carboxamide
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2-(3-fluorophenoxy)-N-[4-(2-pyridyl)thiazol-2-yl]acetamide
shows good docking results. The inhibitor halts not only Entamoeba trophozoite proliferation but also cyst formation
2-(3-fluorophenoxy)-N-[4-(pyridin-2-yl)-1,3-thiazol-2-yl]acetamide
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2-cycloheptyl-4-(4-methoxy-3-[4-[4-(2H-tetrazol-5-yl)phenoxy]butoxy]phenyl)-4a,5,8,8a-tetrahydrophthalazin-1(2H)-one
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2-cycloheptyl-5-(4-methoxy-3-[4-[4-(2H-tetrazol-5-yl)phenoxy]butoxy]phenyl)-4,4-dimethyl-2,4-dihydro-3H-pyrazol-3-one
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3-(methanesulfonyl)-5,7-dimethyl[1,2]thiazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione
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3-phenyl-N-[4-(2-pyridyl)thiazol-2-yl]imidazole-4-carboxamide
shows good docking results. The inhibitor halts not only Entamoeba trophozoite proliferation but also cyst formation
3-[5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-N-[(1-hydroxy-3,3-dimethyl-1,3-dihydro-2,1-benzoxaborol-5-yl)methyl]-5-methylbenzamide
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3-[7-(benzyloxy)-4,8-dimethyl-2-oxo-2H-1-benzopyran-3-yl]propanoic acid
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4-(3-methoxyphenyl)-5-(phenylmethanesulfonyl)-1H-tetrazol-4-ium
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5-bromo-2-chloro-N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)benzamide
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8-(4-methyl-3-[3-[([2-methyl-5-[(4,6,8-trisulfonaphthalen-1-yl)carbamoyl]phenyl]carbamoyl)amino]benzamido]benzamido)naphthalene-1,3,5-trisulfonic acid
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adenylyl sulfate
adenylyl sulfate acts as a strong uncompetitive inhibitor of the APS kinase reaction
ammonium sulfate
high salt inhibits at low adenosine 5'-phosphosulfate concentrations, but activates at high adenosine 5'-phosphosulfate concentrations
auranofin
shows good docking results. The inhibitor halts not only Entamoeba trophozoite proliferation but also cyst formation
N-[2-(5-chloro-2-methoxyanilino)-2-oxoethyl]-N-methyl-2-phenyl-2H-1,2,3-triazole-4-carboxamide
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NaClO3
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6.57 mM, 50% inhibition of brain PAPSS activity, 3.26 mM, 50% inhibition of liver PAPSS
2,4,6-Trinitrobenzene sulfonate
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in the presence or absence of ATP-sulfurylase
adenosine 5'-phosphosulfate
uncompetitive inhibition above 0.001 mM
adenosine 5'-phosphosulfate
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substrate inhibition above 0.03-0.04 mM
adenosine 5'-phosphosulfate
acts as a strong uncompetitive inhibitor of the APS kinase reaction
adenosine 5'-phosphosulfate
adenosine 5'-phosphosulfate can bind to E-MgADP forming a catalytically inactive E-MgADP-APS ternary complex
ATP
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in the absence of ATP regenerating system, substrate inhibition above 0.6 mM, in the presence of ATP regenerating system, substrate inhibition above 0.2 mM
ATP
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free form, weak inhibition; MgATP2-: product inhibition, reverse reaction
additional information
validation of in silico molecular docking analysis and an in vitro enzyme activity assay for large scale screening. Inhibitor screening, In silico molecular docking analysis and simulation ranks the binding free energy between a homology modeling structure of EhAPSK and 400 compounds, overview. Analysis of the cytotoxicity
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additional information
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validation of in silico molecular docking analysis and an in vitro enzyme activity assay for large scale screening. Inhibitor screening, In silico molecular docking analysis and simulation ranks the binding free energy between a homology modeling structure of EhAPSK and 400 compounds, overview. Analysis of the cytotoxicity
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additional information
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not inhibited by adenosine 5'-phosphosulfate
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