the MXAN3487 protein displays sequence and structural homology to adenosine 5'-phosphosulfate (APS) kinase family members and contains putative motifs for ATP and APS binding
the MXAN3487 protein displays sequence and structural homology to adenosine 5'-phosphosulfate (APS) kinase family members and contains putative motifs for ATP and APS binding
deletion of gene MXAN3487 significantly delays fruiting body formation and the production of McuA, a spore coat protein secreted by the Myxococcus xanthus Mcu CU system. Delayed expression of mcuABC in DELTAMXAN3487 may be secondary to a cell aggregation defect
deletion of gene MXAN3487 significantly delays fruiting body formation and the production of McuA, a spore coat protein secreted by the Myxococcus xanthus Mcu CU system. Delayed expression of mcuABC in DELTAMXAN3487 may be secondary to a cell aggregation defect
APS kinase catalyses the second reaction in the two-step conversion of inorganic sulphate to 3'-phosphoadenosine 5'-phosphosulfate (PAPS). MXAN3487 is not regulated by sulfur starvation
APS kinase catalyses the second reaction in the two-step conversion of inorganic sulphate to 3'-phosphoadenosine 5'-phosphosulfate (PAPS). MXAN3487 is not regulated by sulfur starvation
although the MXAN3487 locus is not linked to other sulfate assimilation genes, its protein product may have adenosine 5'-phosphosulfate (APS) kinase activity in vivo. The importance of the ATP-binding site for activity is demonstrated. MXAN3487 seems not to function in a reductive sulfate assimilation pathway. The enzyme may phosphorylate molecules structurally related to APS, generating metabolites necessary for Myxococcus xanthus development, and exerts a positive effect on the mcuABC operon whose expression is morphogenesis-dependent. The enzyme is a regulator for the timing of cell aggregation. Protein MXAN3487 is a bona fide APS kinase, the kinase activity of MXAN3487 protein is essential for its function. MXAN3487 is not regulated by sulfur starvation
although the MXAN3487 locus is not linked to other sulfate assimilation genes, its protein product may have adenosine 5'-phosphosulfate (APS) kinase activity in vivo. The importance of the ATP-binding site for activity is demonstrated. MXAN3487 seems not to function in a reductive sulfate assimilation pathway. The enzyme may phosphorylate molecules structurally related to APS, generating metabolites necessary for Myxococcus xanthus development, and exerts a positive effect on the mcuABC operon whose expression is morphogenesis-dependent. The enzyme is a regulator for the timing of cell aggregation. Protein MXAN3487 is a bona fide APS kinase, the kinase activity of MXAN3487 protein is essential for its function. MXAN3487 is not regulated by sulfur starvation
homology modeling of the APSK domain structure of EhAPSK using three structures as templates (PDB IDs: 3UIE, 4FXP, and 2GKS), overview. All combinations of the three predicted structures are calculated by visual molecular dynamics
homology modeling of the APSK domain structure of EhAPSK using three structures as templates (PDB IDs: 3UIE, 4FXP, and 2GKS), overview. All combinations of the three predicted structures are calculated by visual molecular dynamics