2.7.1.23: NAD+ kinase

This is an abbreviated version!
For detailed information about NAD+ kinase, go to the full flat file.

Reaction

Synonyms

Afnk, AtNADK1, AtNADK2, AtNADK3, ATP: NAD(H) 2'-phosphotransferase, ATP:NAD 2'-phosphotransferase, ATP:NAD+ 2'-phosphotransferase, BsNADK, C5orf33, C5orf33 protein, diphosphopyridine nucleotide kinase, diphosphppyridine kinase, DPN kinase, EC 2.7.1.23, GmNADK1, GmNADK2, GmNADK3, GmNADK4, GmNADK5, HsNADK, kinase (phosphorylating), nicotinamide adenine dinucleotide, kinase, nicotinamide adenine dinucleotide (phosphorylating), MJ0917, NAD kinase, NAD kinase 1, NAD kinase 2, NAD kinase2, NAD(H) kinase, NadF, NADHK, NADK, NADK1, NADK2, NADK3, NADP phosphatase/NAD kinase, native plant calcium- and calmodulin-dependent NAD+-kinase, nicotinamide adenine dinucleotide kinase, OsNADK1, PH1074, Poly(P)/ATP NAD kinase , poly(P)/ATP-NAD kinase, poly(P)/ATPdependent NAD kinase, polyP/ATP-dependent NAD kinase, polyphosphate/ATP-NAD kinase, Pos5, Ppnk, PPNK_THEMA, sll1415, SlNADK1, SlNADK2, slr0040, slr0400, slr1415, SpNADK1, SpNADK2, styNadK, Utr, Utr1, Utr1p, YEF1, Yef1p, YfjB, YjbN, YtdI

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.1 Phosphotransferases with an alcohol group as acceptor

                2.7.1.23 NAD+ kinase

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Results	in table
32	Activating Compound
44601	AA Sequence
42	Application
1	CAS Registry Number
29	Cloned(Commentary)
42	Cofactor
9	Crystallization (Commentary)
68	Disease/ Diagnostics
11	Expression
26	General Information
7	General Stability
172	Inhibitors
23	kcat/KM [mM/s]
79	Ki Value [mM]
142	KM Value [mM]
41	Localization
69	Metals/Ions
61	Molecular Weight [Da]
33	Natural Substrates/ Products (Substrates)
549	Organism
10	Pathway
139	PDB ID
35	pH Optimum
11	pH Range
9	pH Stability
3	pI Value
2	Posttranslational Modification
48	Protein Variants
39	Purification (Commentary)
8	Reaction
1	Reaction Type
149	Reference
1	Renatured (Commentary)
121	Source Tissue
36	Specific Activity [micromol/min/mg]
8	Storage Stability
275	Substrates and Products (Substrate)
71	Subunits
143	Synonyms
1	Systematic Name
10	Temperature Optimum [°C]
4	Temperature Range [°C]
21	Temperature Stability [°C]
41	Turnover Number [1/s]

Temperature Stability

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Temperature Stability on EC 2.7.1.23 - NAD+ kinase

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TEMPERATURE STABILITY

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

100

Pyrococcus horikoshii

O58801

10 min, 20% residual activity

660762

20

Azotobacter vinelandii

-

20 min, 12% loss of activity

641177

30

Azotobacter vinelandii

-

20 min, 37% loss of activity

641177

38

Azotobacter vinelandii

-

20 min, 70% loss of activity. 5 min, about 50% loss of activity

641177

40

2 entries

45 - 60

Corynebacterium glutamicum

-

preheating the enzyme for 1 h at temperatures up to 45°C does not alter the activity. When preheated at 50°C for 1 h, enzyme activity measured at 30°C decreases by 30% and preincubation at 56°C and 60°C leads to a fast and complete loss of activity after 10 and 5 min, respectively

721366

50

Escherichia coli

-

10 min, stable

641189

54

Saccharomyces cerevisiae

-

10 min, 50% loss of activity

661696

55

Gallus gallus

-

immobilized enzyme is more stable than the native enzyme above 55°C

641181

60

2 entries

60 - 68

Columba sp.

-

stable for 5-30 min

641202

63

Sphingomonas sp.

Q6L7J5

10 min, 50% residual activity

663300

65

Escherichia coli

-

10 min, about 45% loss of activity

641189

70

3 entries

95

Pyrococcus horikoshii

O58801

10 min, stable

660762

additional information

2 entries

40

Bacillus subtilis

-

15 min, 50% loss of activity

641186

40

Gallus gallus

-

native enzyme and immobilized enzyme, stable

641181

60

Escherichia coli

-

10 min, about 10% loss of activity

641189

60

Homo sapiens

O95544

5 min, less than 5% loss of activity

641193

70

Corynebacterium glutamicum

-

preincubating the enzyme for 2 h at 70°C results in a loss of 50% of its activity

722144

70

Corynebacterium glutamicum subsp. lactofermentum

-

preheating the enzyme for 2 h at temperatures up to 70°C does not alter the ATP-NAD+ kinase activity significantly (less than 10% of the activity lost)

722144

70

Pyrococcus horikoshii

O58801

60 min, stable in pH-range 4.0-10.5

660762

additional information

Azotobacter vinelandii

-

ATP, NAD+ and 2-mercaptoethanol stabilize against thermal inactivation

641177

additional information

Gallus gallus

-

the enzyme immobilized on CNBr-activated Sepharose is more stable against heat than the native enzyme

641181