2.7.1.23: NAD+ kinase

This is an abbreviated version!
For detailed information about NAD+ kinase, go to the full flat file.

Reaction

Synonyms

Afnk, AtNADK1, AtNADK2, AtNADK3, ATP: NAD(H) 2'-phosphotransferase, ATP:NAD 2'-phosphotransferase, ATP:NAD+ 2'-phosphotransferase, BsNADK, C5orf33, C5orf33 protein, diphosphopyridine nucleotide kinase, diphosphppyridine kinase, DPN kinase, EC 2.7.1.23, GmNADK1, GmNADK2, GmNADK3, GmNADK4, GmNADK5, HsNADK, kinase (phosphorylating), nicotinamide adenine dinucleotide, kinase, nicotinamide adenine dinucleotide (phosphorylating), MJ0917, NAD kinase, NAD kinase 1, NAD kinase 2, NAD kinase2, NAD(H) kinase, NadF, NADHK, NADK, NADK1, NADK2, NADK3, NADP phosphatase/NAD kinase, native plant calcium- and calmodulin-dependent NAD+-kinase, nicotinamide adenine dinucleotide kinase, OsNADK1, PH1074, Poly(P)/ATP NAD kinase , poly(P)/ATP-NAD kinase, poly(P)/ATPdependent NAD kinase, polyP/ATP-dependent NAD kinase, polyphosphate/ATP-NAD kinase, Pos5, Ppnk, PPNK_THEMA, sll1415, SlNADK1, SlNADK2, slr0040, slr0400, slr1415, SpNADK1, SpNADK2, styNadK, Utr, Utr1, Utr1p, YEF1, Yef1p, YfjB, YjbN, YtdI

ECTree

2 Transferases

2.7 Transferring phosphorus-containing groups

2.7.1 Phosphotransferases with an alcohol group as acceptor

2.7.1.23 NAD+ kinase

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Results	in table
32	Activating Compound
44601	AA Sequence
42	Application
1	CAS Registry Number
29	Cloned(Commentary)
42	Cofactor
9	Crystallization (Commentary)
68	Disease/ Diagnostics
11	Expression
26	General Information
7	General Stability
172	Inhibitors
23	kcat/KM [mM/s]
79	Ki Value [mM]
142	KM Value [mM]
41	Localization
69	Metals/Ions
61	Molecular Weight [Da]
33	Natural Substrates/ Products (Substrates)
549	Organism
10	Pathway
139	PDB ID
35	pH Optimum
11	pH Range
9	pH Stability
3	pI Value
2	Posttranslational Modification
48	Protein Variants
39	Purification (Commentary)
8	Reaction
1	Reaction Type
149	Reference
1	Renatured (Commentary)
121	Source Tissue
36	Specific Activity [micromol/min/mg]
8	Storage Stability
275	Substrates and Products (Substrate)
71	Subunits
143	Synonyms
1	Systematic Name
10	Temperature Optimum [°C]
4	Temperature Range [°C]
21	Temperature Stability [°C]
41	Turnover Number [1/s]

Disease

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Disease on EC 2.7.1.23 - NAD+ kinase

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Adenocarcinoma

NADK is activated by oncogenic signaling to sustain pancreatic ductal adenocarcinoma.

34133937

Carcinogenesis

Functional annotation of rare gene aberration drivers of pancreatic cancer.

26806015

Endometrial Neoplasms

Distinct clinical and genetic mutation characteristics in sporadic and Lynch syndrome-associated endometrial cancer in a Chinese population.

34000661

Hyperlysinemias

Clinical heterogeneity of mitochondrial NAD kinase deficiency caused by a NADK2 start loss variant.

29388319

Mitochondrial NADP(H) deficiency due to a mutation in NADK2 causes dienoyl-CoA reductase deficiency with hyperlysinemia.

24847004

Hypersensitivity

NADK2, an Arabidopsis chloroplastic NAD kinase, plays a vital role in both chlorophyll synthesis and chloroplast protection.

16244906

NADK3, a novel cytoplasmic source of NADPH, is required under conditions of oxidative stress and modulates abscisic acid responses in Arabidopsis.

16856986

Mitochondrial Diseases

MNADK, a long-awaited human mitochondrion-localized NAD kinase.

25641397

nad+ kinase deficiency

Clinical heterogeneity of mitochondrial NAD kinase deficiency caused by a NADK2 start loss variant.

29388319

Neoplasms

Enhanced degradation of dihydrofolate reductase through inhibition of NAD kinase by nicotinamide analogs.

23197646

Extramedullary relapse of multiple myeloma defined as the highest risk group based on deregulated gene expression data.

25877407

Functional annotation of rare gene aberration drivers of pancreatic cancer.

26806015

In cancer, all roads lead to NADPH.

33894275

NAD+ Kinase as a Therapeutic Target in Cancer.

27582489

Nervous System Malformations

Lysine Restriction and Pyridoxal Phosphate Administration in a NADK2 Patient.

27940755

Staphylococcal Infections

From Substrate to Fragments to Inhibitor Active In Vivo against Staphylococcus aureus.

32017533

Tuberculosis

A novel fold revealed by Mycobacterium tuberculosis NAD kinase, a key allosteric enzyme in NADP biosynthesis.

15269221

Characterization of Mycobacterium tuberculosis NAD kinase: functional analysis of the full-length enzyme by site-directed mutagenesis.

15182203

Crystallization and preliminary X-ray analysis of NAD kinase from Mycobacterium tuberculosis H37Rv.

11526331

Crystallographic studies of Mycobacterium tuberculosis polyphosphate/ATP-NAD kinase complexed with NAD.

16233726

Establishment of a mass-production system for NADP using bacterial inorganic polyphosphate/ATP-NAD kinase.

16233126

First archaeal inorganic polyphosphate/ATP-dependent NAD kinase, from hyperthermophilic archaeon Pyrococcus horikoshii: cloning, expression, and characterization.

16085824

Inorganic Polyphosphate/ATP-NAD kinase of Micrococcus flavus and Mycobacterium tuberculosis H37Rv.

11006082

Molecular characterization of Escherichia coli NAD kinase.

11488932

NAD-binding mode and the significance of intersubunit contact revealed by the crystal structure of Mycobacterium tuberculosis NAD kinase-NAD complex.

15629142

NADPH regulates human NAD kinase, a NADP(+)-biosynthetic enzyme.

21526340

Overexpression, purification, and characterization of ATP-NAD kinase of Sphingomonas sp. A1.

15177293

Probing binding requirements of NAD kinase with modified substrate (NAD) analogues.

17258457

Selective inhibition of nicotinamide adenine dinucleotide kinases by dinucleoside disulfide mimics of nicotinamide adenine dinucleotide analogues.

19596199