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2.7.1.22: ribosylnicotinamide kinase

This is an abbreviated version!
For detailed information about ribosylnicotinamide kinase, go to the full flat file.

Word Map on EC 2.7.1.22

Reaction

ATP
+
1-(beta-D-ribofuranosyl)-nicotinamide
=
ADP
+
beta-nicotinamide D-ribonucleotide

Synonyms

kinase, ribosylnicotinamide (phosphorylating), More, muscle-specific beta1 integrin binding protein, NadR, nicotinamide ribose kinase, nicotinamide riboside kinase, nicotinamide riboside kinase 1, nicotinamide riboside kinase 2, nicotinamide riboside kinase-2, NmR-K, NMRK1, NMRK2, NR kinase 1, Nrk, NRK-2, NRK1, Nrk2, Nrk2b

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.22 ribosylnicotinamide kinase

Crystallization

Crystallization on EC 2.7.1.22 - ribosylnicotinamide kinase

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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
hanging drop vapor diffusion, 10 mg/ml protein in 100 mM Hepes, pH 7.2, 300 mM NaCl, 1 mM dithiothreitol are incubated with 3 mM NAD and 3 mM ATP and mixed with an equal volume of the reservoir solution consisting of 100 mM MES, pH 6.0, 1 M ammonium sulfate, crystal structure of enzyme complexed with NAD
-
sitting-drop vapor-diffusion method at 22°C, crystal structures of NRK1 in a binary complex with the reaction product nicotinamide mononucleotide at 1.5 A resolution and in a ternary complex with ADP and tiazofurin at 2.7 A resolution. The active site is located in a groove between the central parallel beta sheet core and the LID and NMP-binding domains