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2.7.1.21: thymidine kinase

This is an abbreviated version!
For detailed information about thymidine kinase, go to the full flat file.

Word Map on EC 2.7.1.21

Reaction

ATP
+
thymidine
=
ADP
+
dTMP

Synonyms

2'-deoxythymidine kinase, ATP-thymidine 5'-phosphotransferase, beta-thymidine kinase-1, beta-thymidine kinase-2, calmodulin-binding protein, CaM-binding protein, CaMBP, CHV-TK, dThd kinase-1, dThd kinase-2, EC 2.7.1.75, EHV4-TK, FHV-TK, HSV-1 TK, HSV1-TK, kinase, deoxythymidine (phosphorylating), kinase, thymidine (phosphorylating), LMJF_21_1210, mitochondrial thymidine kinase, More, Mt-TK, TdR kinase, ThyB, thymidine kinase, thymidine kinase 1, thymidine kinase 2, thymidine kinase 2, mitochondrial, thymidine kinase I, thymidine kinase-1, thymidine kinase-2, thymidylate kinase, TK, TK-1, TK-2, TK1, TK1a, TK1b, TK2, type 1 thymidine kinase, type II thymidine kinase 1, UL23, VVTK

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.21 thymidine kinase

KI Value

KI Value on EC 2.7.1.21 - thymidine kinase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.003
2'-deoxy-3'-aminothymidine
-
pH 7.8, 37°C
0.011 - 0.0515
2'-exo-methanocarba-thymidine
0.0039
3'-azido-2',3'-dideoxy-3,4-dihydrothymidine
0.0014
3'-deoxy-3'-fluorothymidine
-
pH and temperature not specified in the publication
0.0014
3'-fluorothymidine
-
pH and temperature not specified in the publication
1.7
3-N-methyl-5-iodo-2'-deoxyuridine
-
pH 7.8, 37°C
3
5'-aminothymidine
-
pH 7.8, 37°C
0.0104
5-(E)-(2-bromovinyl)uridine
-
thymidine kinase 2, in 50 mM Tris/HCl, pH 8.0, 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, at 37°C
0.00013 - 0.0055
5-bromodeoxyuridine
0.00072 - 0.096
5-fluorodeoxyuridine
0.001 - 0.0045
5-iododeoxyuridine
-
pH 7.5, 27°C
0.3
acyclovir
Herpes simplex virus
-
pH 7.8, 37°C
0.4 - 6.5
ADP
3.8
ATP
Tequatrovirus T4
-
pH 7, 37°C
0.001
Be2+
-
pH 8, 37°C
7.5
Caffeine
-
pH 7.8, 37°C
0.00036 - 0.002
dCTP
0.004 - 0.63
deoxycytidine
0.00146 - 1.54
deoxyuridine
0.5 - 0.65
dTDP
-
pH 7.5, 27°C
0.65 - 4.7
dTMP
0.0002 - 0.036
dTTP
0.014
iododeoxycytidine
Herpes simplex virus
-
pH 7.8, 37°C
2.5
Mg2+
Tequatrovirus T4
-
pH 7, 37°C
0.0036 - 0.006
thymidine
0.63
TMP
-
pH 7.4, 37°C
0.0085 - 0.0135
TTP
additional information
additional information
-