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2.7.1.207: protein-Npi-phosphohistidine-lactose phosphotransferase

This is an abbreviated version!
For detailed information about protein-Npi-phosphohistidine-lactose phosphotransferase, go to the full flat file.

Word Map on EC 2.7.1.207

Reaction

[protein]-Npi-phospho-L-histidine
+
lactose[side 1]
=
[protein]-L-histidine
+
lactose 6'-phosphate[side 2]

Synonyms

EC 2.7.1.69, EIICBLac, EIILac, enzyme II specific for lactose, Enzyme IIlac, IIALacS, IICBlac, lac-permease, lacE, lacEF, LACS, lactose permease, lactose PTS permease, lactose specific component of the PEP dependant phosphotransferase system, lactose transport protein, lactose transporter, lactose-specific Enzyme I1, lactose-specific enzyme II, lactose-specific permease enzyme IICB, lactose/galactose-specific permease, lacY, LacY permease, PTS 6CB, PTS 8C

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.207 protein-Npi-phosphohistidine-lactose phosphotransferase

Expression

Expression on EC 2.7.1.207 - protein-Npi-phosphohistidine-lactose phosphotransferase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
enzyme IIAGlc mediates inhibition of lactose uptake and downregulation of the lac expression level
-
isoforms PTS 6CB and PTS 8Care induced in the presence of lactose 107and 53fold, respectively
lactose permease activity in the overproducer strain of phosphocarrier protein of the phosphotransferase system, specific for glucose is reduced to an extremely low level in the presence of methyl alpha-glucoside
-
the presence of isopropyl-beta-thiogalactoside plus cyclic AMP results in enhanced synthesis of the lactose permease