2.7.1.20: adenosine kinase
This is an abbreviated version!
For detailed information about adenosine kinase, go to the full flat file.
Word Map on EC 2.7.1.20
-
2.7.1.20
-
nucleoside
-
deaminase
-
purine
-
amp
-
adenylate
-
inosine
-
salvage
-
hypoxanthine
-
epilepsy
-
phosphoribosyltransferase
-
5'-nucleotidase
-
5-iodotubercidin
-
riboside
-
deoxyadenosine
-
s-adenosylhomocysteine
-
deoxycytidine
-
aicar
-
anticonvulsant
-
tubercidin
-
dipyridamole
-
neuromodulator
-
ehna
-
2\'-deoxycoformycin
-
ecto-5\'-nucleotidase
-
ribokinase
-
erythro-9-2-hydroxy-3-nonyl
-
adenosinergic
-
6-methylmercaptopurine
-
3hadenosine
-
2-chloroadenosine
-
coformycin
-
nitrobenzylthioinosine
-
epileptogenesis
-
hypoxanthine-guanine
-
transmethylation
-
adenosine-induced
-
hgprt
-
kinase-deficient
-
2'-deoxyadenosine
-
adenosine-mediated
-
3.5.4.4
-
deoxycoformycin
-
non-nucleoside
-
analysis
-
2.4.2.8
-
9-beta-d-arabinofuranosyladenine
-
n6-cyclopentyladenosine
-
erythro-9-2-hydroxy-3-nonyladenine
-
dado
-
ara-a
-
medicine
-
diagnostics
-
rephosphorylation
-
pharmacology
- 2.7.1.20
- nucleoside
- deaminase
- purine
- amp
- adenylate
- inosine
-
salvage
- hypoxanthine
- epilepsy
-
phosphoribosyltransferase
- 5'-nucleotidase
- 5-iodotubercidin
- riboside
- deoxyadenosine
- s-adenosylhomocysteine
- deoxycytidine
- aicar
-
anticonvulsant
- tubercidin
- dipyridamole
-
neuromodulator
- ehna
-
2\'-deoxycoformycin
-
ecto-5\'-nucleotidase
- ribokinase
-
erythro-9-2-hydroxy-3-nonyl
-
adenosinergic
- 6-methylmercaptopurine
-
3hadenosine
- 2-chloroadenosine
- coformycin
-
nitrobenzylthioinosine
-
epileptogenesis
-
hypoxanthine-guanine
-
transmethylation
-
adenosine-induced
- hgprt
-
kinase-deficient
- 2'-deoxyadenosine
-
adenosine-mediated
-
3.5.4.4
- deoxycoformycin
-
non-nucleoside
- analysis
-
2.4.2.8
- 9-beta-d-arabinofuranosyladenine
-
n6-cyclopentyladenosine
-
erythro-9-2-hydroxy-3-nonyladenine
-
dado
- ara-a
- medicine
- diagnostics
-
rephosphorylation
- pharmacology
Reaction
Synonyms
adenosine kinase (phosphorylating), ADK, AdK-L, AdK-S, Ado kinase, AdoK, AK, ATP:adenosine 5'-phosphotransferase, CpAK, hADK, kinase, adenosine (phosphorylating), LdAdK, MGG_06270, Rv2202c, Tb927.6.2360, TbAK
ECTree
2.7.1.20 adenosine kinaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 2.7.1.20 - adenosine kinase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + 2'-amino-2',3'-dideoxyadenosine
ADP + 2'-amino-2',3'-dideoxyadenosine 5'-phosphate
-
-
-
-
?
ATP + 2,3-difluoro-3-deaza-7-isoadenosine
ADP + 2,3-difluoro-3-deaza-7-isoadenosine 5'-phosphate
ATP + 2,6-diaminopurine riboside
ADP + 2,6-diaminopurine riboside 5'-phosphate
-
-
-
-
?
ATP + 2-(4-benzylpiperazin-1-yl)adenosine
ADP + 2-(4-benzylpiperazin-1-yl)adenosine 5'-phosphate
-
3% of the activity with adenosine
-
-
?
ATP + 2-(pyrrolidin-1-yl)adenosine
ADP + 2-(pyrrolidin-1-yl)adenosine 5'-phosphate
-
53% of the activity with adenosine
-
-
?
ATP + 2-amino-carbocyclic-adenosine
?
-
35.8% of the activity with adenosine
-
-
?
ATP + 2-benzylaminoadenosine
ADP + 2-benzylaminoadenosine 5'-phosphate
-
4% of the activity with adenosine
-
-
?
ATP + 2-cyclohexylaminoadenosine
ADP + 2-cyclohexylaminoadenosine 5'-phosphate
-
3% of the activity with adenosine
-
-
?
ATP + 2-ethylaminoadenosine
ADP + 2-ethylaminoadenosine 5'-phosphate
-
3% of the activity with adenosine
-
-
?
ATP + 2-fluoro-3-deaza-adenosine
ADP + 2-fluoro-3-deaza-AMP
-
1.7% of the activity with adenosine
-
-
?
ATP + 2-fluoro-3-deazaadenosine
ADP + 2-fluoro-3-deazaadenosine 5'-phosphate
-
specific activity 63 nM/mg/min
-
-
?
ATP + 2-fluoro-9-[beta-D-arabinofuranosyl]-adenine
ADP + 2-fluoro-9-[beta-D-arabinofuranosyl]-AMP
0.9% of the activity with adenosine
-
-
?
ATP + 2-fluoro-adenosine
ADP + 2-fluoro-AMP
52% of the activity with adenosine
-
-
?
ATP + 2-isopropylamino-N6-isopropyladenosine
ADP + 2-isopropylamino-N6-isopropyladenosine 5'-phosphate
-
81% of the activity with adenosine
-
-
?
ATP + 2-isopropylaminoadenosine
ADP + 2-isopropylaminoadenosine 5'-phosphate
-
4% of the activity with adenosine
-
-
?
ATP + 2-methyl-adenosine
ADP + 2-methyl-AMP
2% of the activity with adenosine
-
-
?
ATP + 3-deazaadenosine
ADP + 3-deaza-AMP
-
0.03% of the activity with adenosine
-
-
?
ATP + 3-deazaadenosine
ADP + 3-deazaadenosine 5'-phosphate
-
specific activity 1 nM/mg/min
-
-
?
ATP + 3-[beta-D-ribofuranosyl]-adenine
?
-
11.2% of the activity with adenosine
-
-
?
ATP + 3-[beta-D-ribofuranosyl]-adenine
ADP + 3-[beta-D-ribofuranosyl]-AMP
0.7% of the activity with adenosine
-
-
?
ATP + 6-bromopurine riboside
ADP + 6-bromopurine riboside 5'-phosphate
-
-
-
-
?
ATP + 6-fluoromethylpurine riboside
ADP + 6-fluoromethylpurine riboside 5'-phosphate
-
-
-
-
?
ATP + 6-methyl-purine riboside
ADP + 6-methylpurine-D-riboside 5'-phosphate
2.75% of the activity with adenosine
-
-
?
ATP + 6-methylmercaptopurine riboside
ADP + 6-methylmercaptopurine-D-riboside 5'-phosphate
ATP + 8-aza-adenosine
ADP + 8-aza-AMP
4% of the activity with adenosine
-
-
?
ATP + 8-aza-carbocyclic-adenosine
ADP + 8-aza-carbocyclic-AMP
4% of the activity with adenosine
-
-
?
ATP + 9-[alpha-L-lyxofuranosyl]-2-fluoro-adenine
ADP + 9-[alpha-L-lyxofuranosyl]-2-fluoro-AMP
3.3% of the activity with adenosine
-
-
?
ATP + 9-[alpha-L-lyxofuranosyl]-adenine
?
-
15% of the activity with adenosine
-
-
?
ATP + 9-[alpha-L-lyxofuranosyl]-adenine
ADP + 9-[alpha-L-lyxofuranosyl]-AMP
3.8% of the activity with adenosine
-
-
?
ATP + 9-[beta-D-5-methyl-(allo)-ribofuranosyl]-2-fluoro-adenine
ADP + 9-[beta-D-5-methyl-(allo)-ribofuranosyl]-2-fluoro-AMP
0.1% of the activity with adenosine
-
-
?
ATP + 9-[beta-D-arabinofuranosyl]-adenine
?
-
0.25% of the activity with adenosine
-
-
?
ATP + 9-[beta-D-arabinofuranosyl]-adenine
ADP + 9-[beta-D-arabinofuranosyl]-adenine 5'-phosphate
0.6% of the activity with adenosine
-
-
?
ATP + adenosine
?
the obligate intracellular parasite Toxoplasma gondii is incapable of synthesizing purine nucleotides de novo and relies completely on purines salvaged from the host cells. Adenosine is the preferred precursor and is phosphorylated by adenosine kinase (AK), the most active enzyme in adenosine metabolism in Toxoplasma gondii
-
-
?
ATP + arabinofuranosyladenine
ADP + arabinofuranosyladenine 5'-phosphate
-
-
-
-
?
ATP + aristeromycin
ADP + aristeromycin 5'-phosphate
37.5% of the activity with adenosine
-
-
?
ATP + N1-oxy-N6-methyladenosine
ADP + N1-oxy-N6-methyladenosine 5'-phosphate
-
-
-
-
?
ATP + N6-delta2-isopentenyl-adenosine
ADP + N6-delta2-isopentenyl-adenosine 5'-phosphate
-
-
-
-
?
ATP + N6-methyl-3'-deoxyadenosine
ADP + N6-methyl-3'-deoxyadenosine 5'-phosphate
-
-
-
-
?
ATP + xylofuranosyladenine
ADP + xylofuranosyladenine 5'-phosphate
-
-
-
-
?
dGTP + adenosine
dGDP + AMP
4.7fold higher activity compared to ATP
-
-
?
ATP + 2'-deoxy-2,2'-difluoro-adenosine
ADP + 2'-deoxy-2,2'-difluoro-AMP
0.5% of the activity with adenosine
-
-
?
ATP + 2'-deoxy-2,2'-difluoro-adenosine
ADP + 2'-deoxy-2,2'-difluoro-AMP
0.5% of the activity with adenosine
-
-
?
ATP + 2'-deoxy-adenosine
ADP + 2'-deoxy-AMP
0.3% of the activity with adenosine
-
-
?
ATP + 2'-deoxy-adenosine
ADP + 2'-deoxy-AMP
0.3% of the activity with adenosine
-
-
?
ATP + 2'-deoxy-adenosine
ADP + 2'-deoxy-AMP
-
-
-
-
?
ATP + 2,3-difluoro-3-deaza-7-iso-adenosine
ADP + 2,3-difluoro-3-deaza-7-iso-AMP
-
0.2% of the activity with adenosine
-
-
?
ATP + 2,3-difluoro-3-deaza-7-iso-adenosine
ADP + 2,3-difluoro-3-deaza-7-iso-AMP
-
0.03% of the activity with adenosine
-
-
?
ATP + 2,3-difluoro-3-deaza-7-isoadenosine
ADP + 2,3-difluoro-3-deaza-7-isoadenosine 5'-phosphate
-
specific activity: 5 nM/mg/min
-
-
?
ATP + 2,3-difluoro-3-deaza-7-isoadenosine
ADP + 2,3-difluoro-3-deaza-7-isoadenosine 5'-phosphate
-
specific activity1 1 nM/mg/min
-
-
?
ATP + 2,3-difluoro-3-deaza-adenosine
ADP + 2,3-difluoro-3-deaza-AMP
-
0.2% of the activity with adenosine
-
-
?
ATP + 2,3-difluoro-3-deaza-adenosine
ADP + 2,3-difluoro-3-deaza-AMP
-
2.2% of the activity with adenosine
-
-
?
ATP + 2,3-difluoro-3-deazaadenosine
ADP + 2,3-difluoro-3-deazaadenosine 5'-phosphate
-
specific activity: 1 nM/mg/min
-
-
?
ATP + 2,3-difluoro-3-deazaadenosine
ADP + 2,3-difluoro-3-deazaadenosine 5'-phosphate
-
specific activity 81 nM/mg/min
-
-
?
ATP + 2-amino-carbocyclic-adenosine
ADP + 2-amino-carbocyclic-AMP
0.4% of the activity with adenosine
-
-
?
ATP + 2-amino-carbocyclic-adenosine
ADP + 2-amino-carbocyclic-AMP
0.4% of the activity with adenosine
-
-
?
ATP + 2-chloro-adenosine
ADP + 2-chloro-AMP
11.5% of the activity with adenosine
-
-
?
ATP + 2-chloro-adenosine
ADP + 2-chloro-AMP
11.5% of the activity with adenosine
-
-
?
ATP + 2-chloroadenosine
ADP + 2-chloroadenosine 5'-phosphate
-
-
-
-
?
ATP + 2-fluoroadenosine
ADP + 2-fluoroadenosine 5'-phosphate
-
-
-
-
?
ATP + 2-methyladenosine
ADP + 2-methyl-AMP
activation of 2-mehyladenosine
-
-
?
ATP + 2-methyladenosine
ADP + 2-methyl-AMP
30fold lower activity compared to adenosine
-
-
?
ATP + 2-methyladenosine
ADP + 2-methyl-AMP
Mycobacterium tuberculosis H37Ra / ATCC 25177
activation of 2-mehyladenosine
-
-
?
ATP + 3'-amino-3'-deoxyadenosine
ADP + 3'-amino-3'-deoxyadenosine 5'-phosphate
-
-
-
-
?
ATP + 3'-amino-3'-deoxyadenosine
ADP + 3'-amino-3'-deoxyadenosine 5'-phosphate
-
-
-
-
?
ATP + 3-fluoro-3-deaza-adenosine
ADP + 3-fluoro-3-deaza-AMP
-
0.04% of the activity with adenosine
-
-
?
ATP + 3-fluoro-3-deaza-adenosine
ADP + 3-fluoro-3-deaza-AMP
-
0.4% of the activity with adenosine
-
-
?
ATP + 3-fluoro-3-deazaadenosine
ADP + 3-fluoro-3-deazaadenosine 5'-phosphate
-
specific activity: 1 nM/mg/min
-
-
?
ATP + 3-fluoro-3-deazaadenosine
ADP + 3-fluoro-3-deazaadenosine 5'-phosphate
-
specific activity 16 nM/mg/min
-
-
?
ATP + 6-chloropurine riboside
ADP + 6-chloropurine riboside 5'-phosphate
-
-
-
-
?
ATP + 6-chloropurine riboside
ADP + 6-chloropurine riboside 5'-phosphate
-
-
-
-
?
ATP + 6-methylmercaptopurine riboside
ADP + 6-methylmercaptopurine-D-riboside 5'-phosphate
-
-
-
-
?
ATP + 6-methylmercaptopurine riboside
ADP + 6-methylmercaptopurine-D-riboside 5'-phosphate
-
-
-
-
?
ATP + 8-aza-9-deazaadenosine
ADP + 8-aza-9-deazaadenosine 5'-phosphate
-
-
-
-
?
ATP + 8-aza-9-deazaadenosine
ADP + 8-aza-9-deazaadenosine 5'-phosphate
-
-
-
-
?
ATP + 9-[beta-D-ribofuranosyl]-purine
ADP + 9-[beta-D-ribofuranosyl]-purine 5'-phosphate
-
-
-
-
?
ATP + 9-[beta-D-ribofuranosyl]-purine
ADP + 9-[beta-D-ribofuranosyl]-purine 5'-phosphate
-
-
-
-
?
ATP + adenosine
ADP + AMP
-
the enzyme is highly specific for adenosine and shows best activity with ATP as cosubstrate
-
-
?
ATP + adenosine
ADP + AMP
the enzyme catalyzes the salvage synthesis of 5'-AMP from ADP and ATP
-
-
?
ATP + adenosine
ADP + AMP
-
the enzyme is involved in adenosine and adenine salvage and interconversion of cytokinin ribosides and nucleotides, housekeeping enzymes, essential for maintainance of S-adenosyl-methionine-dependent transmethylation activities, metabolic role, overview
-
-
?
ATP + adenosine
ADP + AMP
adenosine kinase modulates root gravitropism and cap morphogenesis
-
-
?
ATP + adenosine
ADP + AMP
-
the enzyme is involved in adenosine and adenine salvage and interconversion of cytokinin ribosides and nucleotides, metabolic role, overview
-
-
?
ATP + adenosine
ADP + AMP
-
the enzyme is specific for nucleosides, it repels the entrance of phosphorylated sugars
-
?
ATP + adenosine
ADP + AMP
adenosine kinase (ADK) is the first enzyme in the adenosine remediation pathway that catalyzes adenosine phosphorylation into adenosine monophosphate, thus regulating adenosine homeostasis in cells
-
-
?
ATP + adenosine
ADP + AMP
-
key enzyme for the regulation of intracellular adenosine level
-
?
ATP + adenosine
ADP + AMP
-
no phosphorylation of inosine or guanosine
-
-
?
ATP + adenosine
ADP + AMP
-
reaction in salvage pathway for adenosine from nucleosides
-
?
ATP + adenosine
ADP + AMP
-
pyrimidine nucleoside triphosphates are less efficient than purine derivatives, deoxyribonucleotides less efficient than ribonucleotides
-
-
?
ATP + adenosine
ADP + AMP
intracellular adenosine, which is controlled by the key molecular regulator adenosine kinase, influences endothelial inflammation and vascular inflammatory diseases
-
-
?
ATP + adenosine
ADP + AMP
-
the enzyme is involved in adenosine and adenine salvage and interconversion of cytokinin ribosides and nucleotides, metabolic role, overview
-
-
?
ATP + adenosine
ADP + AMP
the major route of myocardial adenosine metabolism. Receptor-independent role of adenosine for adenosine kinase-mediated adenosine metabolism in cardiomyocyte microtubule dynamics and protection against maladaptive hypertrophy
-
-
?
ATP + adenosine
ADP + AMP
-
specific activity: 3700 nM/mg/min
-
-
?
ATP + adenosine
ADP + AMP
essential enzyme of Mycobacterium tuberculosis and forms part of the purine salvage pathway within mycobacteria
-
-
?
ATP + adenosine
ADP + AMP
essential enzyme of Mycobacterium tuberculosis and forms part of the purine salvage pathway within mycobacteria
-
-
?
ATP + adenosine
ADP + AMP
-
the enzyme catalyzes the salvage synthesis of 5'-AMP from ADP and ATP
-
-
?
ATP + adenosine
ADP + AMP
key enzyme in regulation of intracellular adenosine level, responsible, especially isozyme ADK2S, for the conversion of cytokinin ribosides into their respective nucleotides, accumulation of enzyme and increased activity just prior to mitosis is associated with a very active cytokinin metabolism at that phase of the cell cycle in cell culture, overview
-
-
?
ATP + adenosine
ADP + AMP
-
the enzyme is involved in adenosine and adenine salvage and interconversion of cytokinin ribosides and nucleotides, part of the defense response against viral infection, metabolic role, overview
-
-
?
ATP + adenosine
ADP + AMP
ATP:Mg2+ ratio of 4:1
-
-
?
ATP + adenosine
ADP + AMP
-
6-N- and 6-S-substituted purine ribonucleosides and 4-substituted pyrazolo-3,4-d-pyrimidine ribonucleosides are also substrates but with low efficiencies
-
-
?
ATP + adenosine
ADP + AMP
-
involved in phosphorylation of many pharmacological active purine nucleosides
-
?
ATP + adenosine
ADP + AMP
-
the enzyme is involved in adenosine and adenine salvage and interconversion of cytokinin ribosides and nucleotides, the metabolic route also utilizes exogenously fed and incorporated isopentenyladenosine involving the enzyme, metabolic role, overview
-
-
?
ATP + adenosine
ADP + AMP
-
the enzyme is involved in adenosine and adenine salvage and interconversion of cytokinin ribosides and nucleotides, metabolic role, overview
-
-
?
ATP + adenosine
ADP + AMP
-
variation in activity during autumn-winter periods
-
?
ATP + adenosine
ADP + AMP
-
key enzyme for the regulation of intracellular adenosine level
-
?
ATP + adenosine
ADP + AMP
-
the reverse reaction can be detected only if coupled with the adenosine deaminase reaction. This series of reactions transforms adenosine into inosine + NH3
-
-
r
ATP + adenosine
ADP + AMP
-
key enzyme for the regulation of intracellular adenosine level
-
?
ATP + adenosine
ADP + AMP
-
the enzyme is involved in adenosine and adenine salvage and interconversion of cytokinin ribosides and nucleotides, metabolic role, overview
-
-
?
ATP + adenosine
ADP + AMP
-
the enzyme is involved in adenosine and adenine salvage and interconversion of cytokinin ribosides and nucleotides, metabolic role, overview
-
-
?
ATP + adenosine
ADP + AMP
-
enzyme shows highest activity of all enzymes involved in the adenosine salvage metabolism
-
-
?
ATP + adenosine
ADP + AMP
ATP is the preferred phosphoryl donor
-
-
?
ATP + adenosine-1-N-oxide
ADP + adenosine-1-N-oxide 5'-phosphate
-
-
-
?
ATP + adenosine-1-N-oxide
ADP + adenosine-1-N-oxide 5'-phosphate
-
-
-
?
ATP + N6-methyladenosine
ADP + N6-methyladenosine 5'-phosphate
-
-
-
?
GTP + adenosine
GDP + AMP
2.5fold higher activity compared to ATP
-
-
?
GTP + adenosine
GDP + AMP
Mycobacterium tuberculosis H37Ra / ATCC 25177
2.5fold higher activity compared to ATP
-
-
?
additional information
?
-
-
the organism prefers the minor route of adenosine salvage/recycling via adenosine deaminase, EC 3.5.4.4, and adenosine nucleosidase, EC 3.2.2.9, compared to the major route via adenosine kinase, overview
-
-
?
additional information
?
-
-
development of methods for analyzing the enzymatic reaction of adenosine kinase. These methods allow to measure substrates and potential inhibitors for adenosine kinase within a few min with high accuracy and reproducibility by means of capillary electrophoresis
-
-
?
additional information
?
-
-
hypoxia inducible factor 1-alpha-dependent repression of adenosine kinase attenuates hypoxia-induced vascular leak
-
-
?
additional information
?
-
-
cyclophilin (LdCyP) dislocated into the cytoplasm of the stressed cells most likely is responsible for reactivation of the AdK activity. R147 of cyclophilin is the most crucial residue in the LdCyP-AdK interaction
-
-
?
additional information
?
-
-
under the condition of cellular stress, the ER-located cyclophilins LdCyP is released into the cytoplasm with concomitant increase both in the specific activity of the cytosol-resident AdK and the uptake of radiolabeled Ado into the cells
-
-
?
additional information
?
-
-
low levels of ADK are essential to maintain adenosine-mediated neuroprotection
-
-
?
additional information
?
-
dATP, UTP, dTTP, CTP, and dCTP are poor phosphate donors
-
-
?
additional information
?
-
-
dATP, UTP, dTTP, CTP, and dCTP are poor phosphate donors
-
-
?
additional information
?
-
Mycobacterium tuberculosis H37Ra / ATCC 25177
dATP, UTP, dTTP, CTP, and dCTP are poor phosphate donors
-
-
?
additional information
?
-
-
adenosine kinase suppresses sporulation and actinorhodin biosynthesis while inducing hyperproduction of undecylprodigiosin in Streptomyces lividans
-
-
?
additional information
?
-
hybrid random bi-uni ping-pong uni-bi mechanism, with substrate-enzyme-cosubstrate complex formation, binding pattern indicates that binding of the substrate interferes with the binding of the cosubstrate and vice versa. For every ATP consumed, the enzyme generates three AMPs
-
-
?
additional information
?
-
-
hybrid random bi-uni ping-pong uni-bi mechanism, with substrate-enzyme-cosubstrate complex formation, binding pattern indicates that binding of the substrate interferes with the binding of the cosubstrate and vice versa. For every ATP consumed, the enzyme generates three AMPs
-
-
?
additional information
?
-
-
the enzyme plays a role in susceptibility to adenosine antimetabolites
-
-
?
