2.7.1.20: adenosine kinase
This is an abbreviated version!
For detailed information about adenosine kinase, go to the full flat file.
Word Map on EC 2.7.1.20
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2.7.1.20
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nucleoside
-
deaminase
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purine
-
amp
-
adenylate
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inosine
-
salvage
-
hypoxanthine
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epilepsy
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phosphoribosyltransferase
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5'-nucleotidase
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5-iodotubercidin
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riboside
-
deoxyadenosine
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s-adenosylhomocysteine
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deoxycytidine
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aicar
-
anticonvulsant
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tubercidin
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dipyridamole
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neuromodulator
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ehna
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2\'-deoxycoformycin
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ecto-5\'-nucleotidase
-
ribokinase
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erythro-9-2-hydroxy-3-nonyl
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adenosinergic
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6-methylmercaptopurine
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3hadenosine
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2-chloroadenosine
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coformycin
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nitrobenzylthioinosine
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epileptogenesis
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hypoxanthine-guanine
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transmethylation
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adenosine-induced
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hgprt
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kinase-deficient
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2'-deoxyadenosine
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adenosine-mediated
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3.5.4.4
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deoxycoformycin
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non-nucleoside
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analysis
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2.4.2.8
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9-beta-d-arabinofuranosyladenine
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n6-cyclopentyladenosine
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erythro-9-2-hydroxy-3-nonyladenine
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dado
-
ara-a
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medicine
-
diagnostics
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rephosphorylation
-
pharmacology
- 2.7.1.20
- nucleoside
- deaminase
- purine
- amp
- adenylate
- inosine
-
salvage
- hypoxanthine
- epilepsy
-
phosphoribosyltransferase
- 5'-nucleotidase
- 5-iodotubercidin
- riboside
- deoxyadenosine
- s-adenosylhomocysteine
- deoxycytidine
- aicar
-
anticonvulsant
- tubercidin
- dipyridamole
-
neuromodulator
- ehna
-
2\'-deoxycoformycin
-
ecto-5\'-nucleotidase
- ribokinase
-
erythro-9-2-hydroxy-3-nonyl
-
adenosinergic
- 6-methylmercaptopurine
-
3hadenosine
- 2-chloroadenosine
- coformycin
-
nitrobenzylthioinosine
-
epileptogenesis
-
hypoxanthine-guanine
-
transmethylation
-
adenosine-induced
- hgprt
-
kinase-deficient
- 2'-deoxyadenosine
-
adenosine-mediated
-
3.5.4.4
- deoxycoformycin
-
non-nucleoside
- analysis
-
2.4.2.8
- 9-beta-d-arabinofuranosyladenine
-
n6-cyclopentyladenosine
-
erythro-9-2-hydroxy-3-nonyladenine
-
dado
- ara-a
- medicine
- diagnostics
-
rephosphorylation
- pharmacology
Reaction
Synonyms
adenosine kinase (phosphorylating), ADK, AdK-L, AdK-S, Ado kinase, AdoK, AK, ATP:adenosine 5'-phosphotransferase, CpAK, hADK, kinase, adenosine (phosphorylating), LdAdK, MGG_06270, Rv2202c, Tb927.6.2360, TbAK
ECTree
2.7.1.20 adenosine kinaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 2.7.1.20 - adenosine kinase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + adenosine
?
the obligate intracellular parasite Toxoplasma gondii is incapable of synthesizing purine nucleotides de novo and relies completely on purines salvaged from the host cells. Adenosine is the preferred precursor and is phosphorylated by adenosine kinase (AK), the most active enzyme in adenosine metabolism in Toxoplasma gondii
-
-
?
ATP + 2-methyladenosine
ADP + 2-methyl-AMP
activation of 2-mehyladenosine
-
-
?
ATP + 2-methyladenosine
ADP + 2-methyl-AMP
Mycobacterium tuberculosis H37Ra / ATCC 25177
activation of 2-mehyladenosine
-
-
?
ATP + adenosine
ADP + AMP
the enzyme catalyzes the salvage synthesis of 5'-AMP from ADP and ATP
-
-
?
ATP + adenosine
ADP + AMP
-
the enzyme is involved in adenosine and adenine salvage and interconversion of cytokinin ribosides and nucleotides, housekeeping enzymes, essential for maintainance of S-adenosyl-methionine-dependent transmethylation activities, metabolic role, overview
-
-
?
ATP + adenosine
ADP + AMP
adenosine kinase modulates root gravitropism and cap morphogenesis
-
-
?
ATP + adenosine
ADP + AMP
-
the enzyme is involved in adenosine and adenine salvage and interconversion of cytokinin ribosides and nucleotides, metabolic role, overview
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-
?
ATP + adenosine
ADP + AMP
adenosine kinase (ADK) is the first enzyme in the adenosine remediation pathway that catalyzes adenosine phosphorylation into adenosine monophosphate, thus regulating adenosine homeostasis in cells
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-
?
ATP + adenosine
ADP + AMP
-
key enzyme for the regulation of intracellular adenosine level
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?
ATP + adenosine
ADP + AMP
-
reaction in salvage pathway for adenosine from nucleosides
-
?
ATP + adenosine
ADP + AMP
intracellular adenosine, which is controlled by the key molecular regulator adenosine kinase, influences endothelial inflammation and vascular inflammatory diseases
-
-
?
ATP + adenosine
ADP + AMP
-
the enzyme is involved in adenosine and adenine salvage and interconversion of cytokinin ribosides and nucleotides, metabolic role, overview
-
-
?
ATP + adenosine
ADP + AMP
the major route of myocardial adenosine metabolism. Receptor-independent role of adenosine for adenosine kinase-mediated adenosine metabolism in cardiomyocyte microtubule dynamics and protection against maladaptive hypertrophy
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-
?
ATP + adenosine
ADP + AMP
essential enzyme of Mycobacterium tuberculosis and forms part of the purine salvage pathway within mycobacteria
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-
?
ATP + adenosine
ADP + AMP
essential enzyme of Mycobacterium tuberculosis and forms part of the purine salvage pathway within mycobacteria
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-
?
ATP + adenosine
ADP + AMP
-
the enzyme catalyzes the salvage synthesis of 5'-AMP from ADP and ATP
-
-
?
ATP + adenosine
ADP + AMP
key enzyme in regulation of intracellular adenosine level, responsible, especially isozyme ADK2S, for the conversion of cytokinin ribosides into their respective nucleotides, accumulation of enzyme and increased activity just prior to mitosis is associated with a very active cytokinin metabolism at that phase of the cell cycle in cell culture, overview
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-
?
ATP + adenosine
ADP + AMP
-
the enzyme is involved in adenosine and adenine salvage and interconversion of cytokinin ribosides and nucleotides, part of the defense response against viral infection, metabolic role, overview
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-
?
ATP + adenosine
ADP + AMP
-
involved in phosphorylation of many pharmacological active purine nucleosides
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?
ATP + adenosine
ADP + AMP
-
the enzyme is involved in adenosine and adenine salvage and interconversion of cytokinin ribosides and nucleotides, the metabolic route also utilizes exogenously fed and incorporated isopentenyladenosine involving the enzyme, metabolic role, overview
-
-
?
ATP + adenosine
ADP + AMP
-
the enzyme is involved in adenosine and adenine salvage and interconversion of cytokinin ribosides and nucleotides, metabolic role, overview
-
-
?
ATP + adenosine
ADP + AMP
-
key enzyme for the regulation of intracellular adenosine level
-
?
ATP + adenosine
ADP + AMP
-
key enzyme for the regulation of intracellular adenosine level
-
?
ATP + adenosine
ADP + AMP
-
the enzyme is involved in adenosine and adenine salvage and interconversion of cytokinin ribosides and nucleotides, metabolic role, overview
-
-
?
ATP + adenosine
ADP + AMP
-
the enzyme is involved in adenosine and adenine salvage and interconversion of cytokinin ribosides and nucleotides, metabolic role, overview
-
-
?
ATP + adenosine
ADP + AMP
-
enzyme shows highest activity of all enzymes involved in the adenosine salvage metabolism
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-
?
additional information
?
-
-
the organism prefers the minor route of adenosine salvage/recycling via adenosine deaminase, EC 3.5.4.4, and adenosine nucleosidase, EC 3.2.2.9, compared to the major route via adenosine kinase, overview
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-
?
additional information
?
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-
hypoxia inducible factor 1-alpha-dependent repression of adenosine kinase attenuates hypoxia-induced vascular leak
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-
?
additional information
?
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-
cyclophilin (LdCyP) dislocated into the cytoplasm of the stressed cells most likely is responsible for reactivation of the AdK activity. R147 of cyclophilin is the most crucial residue in the LdCyP-AdK interaction
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-
?
additional information
?
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-
under the condition of cellular stress, the ER-located cyclophilins LdCyP is released into the cytoplasm with concomitant increase both in the specific activity of the cytosol-resident AdK and the uptake of radiolabeled Ado into the cells
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-
?
additional information
?
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-
low levels of ADK are essential to maintain adenosine-mediated neuroprotection
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-
?
additional information
?
-
-
adenosine kinase suppresses sporulation and actinorhodin biosynthesis while inducing hyperproduction of undecylprodigiosin in Streptomyces lividans
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-
?
additional information
?
-
-
the enzyme plays a role in susceptibility to adenosine antimetabolites
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-
?
