2.7.1.20: adenosine kinase
This is an abbreviated version!
For detailed information about adenosine kinase, go to the full flat file.
Word Map on EC 2.7.1.20
-
2.7.1.20
-
nucleoside
-
deaminase
-
purine
-
amp
-
adenylate
-
inosine
-
salvage
-
hypoxanthine
-
epilepsy
-
phosphoribosyltransferase
-
5'-nucleotidase
-
5-iodotubercidin
-
riboside
-
deoxyadenosine
-
s-adenosylhomocysteine
-
deoxycytidine
-
aicar
-
anticonvulsant
-
tubercidin
-
dipyridamole
-
neuromodulator
-
ehna
-
2\'-deoxycoformycin
-
ecto-5\'-nucleotidase
-
ribokinase
-
erythro-9-2-hydroxy-3-nonyl
-
adenosinergic
-
6-methylmercaptopurine
-
3hadenosine
-
2-chloroadenosine
-
coformycin
-
nitrobenzylthioinosine
-
epileptogenesis
-
hypoxanthine-guanine
-
transmethylation
-
adenosine-induced
-
hgprt
-
kinase-deficient
-
2'-deoxyadenosine
-
adenosine-mediated
-
3.5.4.4
-
deoxycoformycin
-
non-nucleoside
-
analysis
-
2.4.2.8
-
9-beta-d-arabinofuranosyladenine
-
n6-cyclopentyladenosine
-
erythro-9-2-hydroxy-3-nonyladenine
-
dado
-
ara-a
-
medicine
-
diagnostics
-
rephosphorylation
-
pharmacology
- 2.7.1.20
- nucleoside
- deaminase
- purine
- amp
- adenylate
- inosine
-
salvage
- hypoxanthine
- epilepsy
-
phosphoribosyltransferase
- 5'-nucleotidase
- 5-iodotubercidin
- riboside
- deoxyadenosine
- s-adenosylhomocysteine
- deoxycytidine
- aicar
-
anticonvulsant
- tubercidin
- dipyridamole
-
neuromodulator
- ehna
-
2\'-deoxycoformycin
-
ecto-5\'-nucleotidase
- ribokinase
-
erythro-9-2-hydroxy-3-nonyl
-
adenosinergic
- 6-methylmercaptopurine
-
3hadenosine
- 2-chloroadenosine
- coformycin
-
nitrobenzylthioinosine
-
epileptogenesis
-
hypoxanthine-guanine
-
transmethylation
-
adenosine-induced
- hgprt
-
kinase-deficient
- 2'-deoxyadenosine
-
adenosine-mediated
-
3.5.4.4
- deoxycoformycin
-
non-nucleoside
- analysis
-
2.4.2.8
- 9-beta-d-arabinofuranosyladenine
-
n6-cyclopentyladenosine
-
erythro-9-2-hydroxy-3-nonyladenine
-
dado
- ara-a
- medicine
- diagnostics
-
rephosphorylation
- pharmacology
Reaction
Synonyms
adenosine kinase (phosphorylating), ADK, AdK-L, AdK-S, Ado kinase, AdoK, AK, ATP:adenosine 5'-phosphotransferase, CpAK, hADK, kinase, adenosine (phosphorylating), LdAdK, MGG_06270, Rv2202c, Tb927.6.2360, TbAK
ECTree
2.7.1.20 adenosine kinaseAdvanced search results
results (
results (IC50 Value
IC50 Value on EC 2.7.1.20 - adenosine kinase
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IC50 VALUE [mM] 
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
0.0075
(+)-6-ethyl-6-[4-[(2,6-dichlorophenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
Homo sapiens
-
at pH 7.5 and 37°C
0.008
(+/-)-6-ethyl-6-[4-[(2,3,5,6-tetrafluorophenylthio)methyl]-phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
Homo sapiens
-
at pH 7.5 and 37°C
0.003
(+/-)-6-ethyl-6-[4-[(2,3-dichlorophenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
Homo sapiens
-
at pH 7.5 and 37°C
0.0225
(+/-)-6-ethyl-6-[4-[(2,4-dichlorophenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
Homo sapiens
-
at pH 7.5 and 37°C
0.01
(+/-)-6-ethyl-6-[4-[(2,4-difluorophenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
Homo sapiens
-
at pH 7.5 and 37°C
0.014
(+/-)-6-ethyl-6-[4-[(2,5-dichlorophenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
Homo sapiens
-
at pH 7.5 and 37°C
0.035
(+/-)-6-ethyl-6-[4-[(2,5-dimethoxyphenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
Homo sapiens
-
at pH 7.5 and 37°C
0.02
(+/-)-6-ethyl-6-[4-[(2,6-dichlorophenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
Homo sapiens
-
at pH 7.5 and 37°C
0.0025
(+/-)-6-ethyl-6-[4-[(2-chloro-4-fluorophenylthio)methyl]-phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
Homo sapiens
-
at pH 7.5 and 37°C
0.0012
(+/-)-6-ethyl-6-[4-[(2-chloro-4-iodophenyloxy)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
Homo sapiens
-
at pH 7.5 and 37°C
0.002
(+/-)-6-ethyl-6-[4-[(2-chloro-4-iodophenylthio)methyl]-phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
Homo sapiens
-
at pH 7.5 and 37°C
0.001
(+/-)-6-ethyl-6-[4-[(2-chlorophenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
Homo sapiens
-
at pH 7.5 and 37°C
0.005
(+/-)-6-ethyl-6-[4-[(2-chlorophenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]thiazepin-7-one
Homo sapiens
-
at pH 7.5 and 37°C
0.0045
(+/-)-6-ethyl-6-[4-[(2-fluorophenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
Homo sapiens
-
at pH 7.5 and 37°C
0.0035
(+/-)-6-ethyl-6-[4-[(2-imidazolylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
Homo sapiens
-
at pH 7.5 and 37°C
0.003
(+/-)-6-ethyl-6-[4-[(2-methyl-6-chlorophenylthio)methyl]-phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
Homo sapiens
-
at pH 7.5 and 37°C
0.007
(+/-)-6-ethyl-6-[4-[(2-pyrazylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
Homo sapiens
-
at pH 7.5 and 37°C
0.0045
(+/-)-6-ethyl-6-[4-[(2-pyridylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
Homo sapiens
-
at pH 7.5 and 37°C
0.007
(+/-)-6-ethyl-6-[4-[(2-pyrimidylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
Homo sapiens
-
at pH 7.5 and 37°C
0.01
(+/-)-6-ethyl-6-[4-[(3,4-dichlorophenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
Homo sapiens
-
at pH 7.5 and 37°C
0.011
(+/-)-6-ethyl-6-[4-[(3-chloro-4-fluorophenylthio)methyl]-phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
Homo sapiens
-
at pH 7.5 and 37°C
0.0035
(+/-)-6-ethyl-6-[4-[(3-chlorophenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
Homo sapiens
-
at pH 7.5 and 37°C
0.004
(+/-)-6-ethyl-6-[4-[(3-fluorophenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
Homo sapiens
-
at pH 7.5 and 37°C
0.0125
(+/-)-6-ethyl-6-[4-[(3-methoxyphenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
Homo sapiens
-
at pH 7.5 and 37°C
0.0214
(+/-)-6-ethyl-6-[4-[(3-methylphenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
Homo sapiens
-
at pH 7.5 and 37°C
0.0032
(+/-)-6-ethyl-6-[4-[(3-trifluoromethoxyphenylthio)methyl]-phenyl]-6,7-dihydrobenzo[b]pyrrolo [1,2-d][1,4]oxazepin-7-one
Homo sapiens
-
at pH 7.5 and 37°C
0.0025
(+/-)-6-ethyl-6-[4-[(3-trifluoromethylphenylthio)methyl]-phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
Homo sapiens
-
at pH 7.5 and 37°C
0.002
(+/-)-6-ethyl-6-[4-[(4-bromophenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
Homo sapiens
-
at pH 7.5 and 37°C
0.015
(+/-)-6-ethyl-6-[4-[(4-ethynylphenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
Homo sapiens
-
at pH 7.5 and 37°C
0.001
(+/-)-6-ethyl-6-[4-[(4-fluorophenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
Homo sapiens
-
at pH 7.5 and 37°C
0.0025
(+/-)-6-ethyl-6-[4-[(4-iodophenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
Homo sapiens
-
at pH 7.5 and 37°C
0.0022
(+/-)-6-ethyl-6-[4-[(4-iodophenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]thiazepin-7-one
Homo sapiens
-
at pH 7.5 and 37°C
0.014
(+/-)-6-ethyl-6-[4-[(4-methoxyphenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
Homo sapiens
-
at pH 7.5 and 37°C
0.0062
(+/-)-6-ethyl-6-[4-[(4-nitrophenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
Homo sapiens
-
at pH 7.5 and 37°C
0.0067
(+/-)-6-ethyl-6-[4-[(4-trifluoromethoxyphenylthio)methyl]-phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
Homo sapiens
-
at pH 7.5 and 37°C
0.0012
(+/-)-6-ethyl-6-[4-[(phenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
Homo sapiens
-
at pH 7.5 and 37°C
0.2
(+/-)-6-ethyl-6-[4-[3-(2-diethylaminoethyl)phenoxymethyl]-phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
Homo sapiens
-
at pH 7.5 and 37°C
0.008
(+/-)-6-ethyl-6-[4-[3-(2-hydroxye)thylphenoxymethyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
Homo sapiens
-
at pH 7.5 and 37°C
0.15
(+/-)-6-ethyl-6-[4-[3-(2-pyrrolidin-1-ylethyl)phenoxymethyl]-phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
Homo sapiens
-
at pH 7.5 and 37°C
0.01
(+/-)-6-ethyl-6-[4-[[4-[2-(trimethylsilyl)ethynyl]phenylthio]-methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
Homo sapiens
-
at pH 7.5 and 37°C
0.002
(+/-)-6-ethyl-6-[4-[[4-[2-(trimethylsilyl)ethynyl]phenylthio]-methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]thiazepin-7-one
Homo sapiens
-
at pH 7.5 and 37°C
0.0044
(+/-)-6-[4-[(2-chlorophenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
Homo sapiens
-
at pH 7.5 and 37°C
0.009
(+/-)-6-[4-[(3-trifluoromethylphenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
Homo sapiens
-
at pH 7.5 and 37°C
0.004
(+/-)-6-[4-[(phenylthio)methyl]phenyl]-6,7-dihydrobenzo-[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
Homo sapiens
-
at pH 7.5 and 37°C
0.04
(-)-6-ethyl-6-[4-[(2,6-dichlorophenylthio)methyl]phenyl]-6,7-dihydrobenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-one
Homo sapiens
-
at pH 7.5 and 37°C
0.00224
(1R,2R,3S,4R,5S)-4-(4-amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-1-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diol
Homo sapiens
37°C, pH not specified in the publication
0.00014
(1R,2R,3S,4R,5S)-4-(4-anilino-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-1-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diol
Homo sapiens
37°C, pH not specified in the publication
0.00538
(1R,2S,3R,4R,5S)-1-(4-amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-4-(azidomethyl)bicyclo[3.1.0]hexane-2,3-diol
Homo sapiens
37°C, pH not specified in the publication
0.00334
(1R,2S,3R,4R,5S)-1-(4-anilino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-4-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diol
Homo sapiens
37°C, pH not specified in the publication
0.000114
(1R,2S,3R,4R,5S)-1-(4-anilino-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-4-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diol
Homo sapiens
37°C, pH not specified in the publication
0.00601
(1R,2S,3R,4R,5S)-1-(4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-4-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diol
Homo sapiens
37°C, pH not specified in the publication
0.000088
(1R,2S,3R,4S,5S)-1-(4-anilino-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-4-methylbicyclo[3.1.0]hexane-2,3-diol
Homo sapiens
37°C, pH not specified in the publication
0.00011
(1R,2S,3R,4S,5S)-1-[4-(4-fluoroanilino)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-4-methylbicyclo[3.1.0]hexane-2,3-diol
Homo sapiens
37°C, pH not specified in the publication
0.000115
(1R,2S,3R,4S,5S)-1-[4-anilino-5-(4-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-4-methylbicyclo[3.1.0]hexane-2,3-diol
Homo sapiens
37°C, pH not specified in the publication
0.000048
(1S,2R,3S,5R)-3-amino-5-(4-amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol
Homo sapiens
37°C, pH not specified in the publication
0.0088
(2R,3S,4R,5R)-2-(hydroxymethyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol
Mycobacterium tuberculosis
-
pH not specified in the publication, temperature not specified in the publication
0.78
(2R,3S,4R,5R)-2-(hydroxymethyl)-5-[4-(1H-imidazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]tetrahydrofuran-3,4-diol
Mycobacterium tuberculosis
-
pH not specified in the publication, temperature not specified in the publication
1
10-(dimethylamino)-6-phenylpyrrolo[2,1-d][1,5]benzothiazepin-7(6H)-one
Homo sapiens
-
IC50 above 1 mM, at pH 7.5 and 37°C
0.0000012
2-fluoro-4-(benzofuran-2-yl)-7-(beta-d-ribofuranosyl)-7H-pyrrolo-[2,3-d]pyrimidine
Mycobacterium tuberculosis
-
pH not specified in the publication, temperature not specified in the publication
0.005
4-(1H-pyrazol-4-yl)-7-(beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine
Homo sapiens
-
IC50 above 0.005 mM, in 50 mM HEPES (pH 6.2), 10 mM KCl, 1 mM MgCl2, temperature not specified in the publication
0.0013
4-(furan-2-yl)-7-(beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine
Homo sapiens
-
in 50 mM HEPES (pH 6.2), 10 mM KCl, 1 mM MgCl2, temperature not specified in the publication
0.01
4-(furan-3-yl)-7-(beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine
Homo sapiens
-
IC50 above 0.01 mM, in 50 mM HEPES (pH 6.2), 10 mM KCl, 1 mM MgCl2, temperature not specified in the publication
0.0006
4-amino-5-iodo-7-(4'-C-spirocyclopropyl-beta-D-erythropentofuranosyl)pyrrolo[2,3-d]pyrimidine
Homo sapiens
-
IC50: 600 nM
0.000006
4-amino-5-iodo-7-(beta-D-erythro-furanosyl)pyrrolo[2,3-d]-pyrimidine
Homo sapiens
-
IC50: 6 nM
0.0000053
4-N-(2-methoxyphenyl)amino-5-(4-ethoxyphenyl)-7-(beta-D-erythro-furanosyl)pyrrolo[2,3-d]pyrimidine
Homo sapiens
-
IC50: 5.3 nM
0.000001
4-N-(3,4-ethylenedioxyphenyl)amino-5-(2-methylphenyl)-7-(beta-D-erythro-furanosyl)pyrrolo[2,3-d]pyrimidine
Homo sapiens
-
IC50: 1 nM
0.000004
4-N-(3,4-ethylenedioxyphenyl)amino-5-phenyl-7-(beta-D-erythro-furanosyl)pyrrolo[2,3-d]pyrimidine
Homo sapiens
-
IC50: 4 nM
0.000002
4-N-(3-ethoxyphenyl)amino-5-phenyl-7-(beta-D-erythrofuranosyl)pyrrolo[2,3-d]pyrimidine
Homo sapiens
-
IC50: 2 nM
0.000005
4-N-(4-bromophenyl)amino-5-phenyl-7-(beta-D-erythrofuranosyl)pyrrolo[2,3-d]pyrimidine
Homo sapiens
-
IC50: 5 nM
0.000007
4-N-(4-cyanophenyl)amino-5-(4-chlorophenyl)-7-(beta-D-erythro-furanosyl)pyrrolo[2,3-d]pyrimidine
Homo sapiens
-
IC50: 7 nM
0.000002
4-N-(4-cyanophenyl)amino-5-(4-ethoxyphenyl)-7-(beta-D-erythro-furanosyl)pyrrolo[2,3-d]pyrimidine
Homo sapiens
-
IC50: 2 nM
0.000003
4-N-(4-ethoxyphenyl)amino-5-phenyl-7-(beta-D-erythrofuranosyl)pyrrolo[2,3-d]pyrimidine
Homo sapiens
-
IC50: 3 nM
0.00001
4-N-(4-fluorophenyl)amino-5-(3-aminophenyl)-7-(beta-D-erythro-furanosyl)pyrrolo[2,3-d]pyrimidine
Homo sapiens
-
IC50: 10 nM
0.0000003
4-N-(4-fluorophenyl)amino-5-phenyl-7-(4'-C-spirocyclopropyl-beta-D-erythro-furanosyl)pyrrolo[2,3-d]pyrimidine
Homo sapiens
-
IC50: 0.3 nM
0.000006
4-N-(4-fluorophenyl)amino-5-phenyl-7-(beta-D-erythrofuranosyl)pyrrolo[2,3-d]pyrimidine
Homo sapiens
-
IC50: 6 nM
0.004
4-N-phenylamino-5-phenyl-7-(5'-deoxy-4'-C-methyl-beta-D-ribo-furanosyl)pyrrolo[2,3-d]pyrimidine
Homo sapiens
-
IC50: 4000 nM
0.000004
4-N-phenylamino-5-phenyl-7-(beta-D-erythro-furanosyl)-pyrrolo[2,3-d]pyrimidine
Homo sapiens
-
IC50: 4 nM
0.00004
5-benzyl-6-[[6-(morpholin-4-yl)pyridin-3-yl]ethynyl]pyrimidin-4-amine
Homo sapiens
pH and temperature not specified in the publication
0.0013
5-fluoro-4-(furan-2-yl)-7-(beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine
Homo sapiens
-
in 50 mM HEPES (pH 6.2), 10 mM KCl, 1 mM MgCl2, temperature not specified in the publication
0.01
5-fluoro-4-(furan-3-yl)-7-(beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine
Homo sapiens
-
IC50 above 0.01 mM, in 50 mM HEPES (pH 6.2), 10 mM KCl, 1 mM MgCl2, temperature not specified in the publication
0.0011
5-fluoro-7-(beta-D-ribofuranosyl)-4-(thiophen-2-yl)-7H-pyrrolo[2,3-d]pyrimidine
Homo sapiens
-
in 50 mM HEPES (pH 6.2), 10 mM KCl, 1 mM MgCl2, temperature not specified in the publication
0.01
5-fluoro-7-(beta-D-ribofuranosyl)-4-(thiophen-3-yl)-7H-pyrrolo[2,3-d]pyrimidine
Homo sapiens
-
IC50 above 0.01 mM, in 50 mM HEPES (pH 6.2), 10 mM KCl, 1 mM MgCl2, temperature not specified in the publication
0.00082
5-iodo-7-beta-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Homo sapiens
37°C, pH not specified in the publication
0.0008 - 0.0133
6-(4-[[(2-chlorophenyl)sulfanyl]methyl]phenyl)-6-ethyl-6,7-dihydropyrrolo[2,1-d][1,5]benzoxazepine
0.15
6-ethyl-6-(3-methylphenyl)pyrrolo[2,1-d][1,5]benzoxazepin-7(6H)-one
Homo sapiens
-
at pH 7.5 and 37°C
0.08
6-ethyl-6-(4-methylphenyl)pyrrolo[2,1-d][1,5]benzoxazepin-7(6H)-one
Homo sapiens
-
at pH 7.5 and 37°C
0.085
6-ethyl-6-phenylpyrrolo[2,1-d][1,5]benzoxazepin-7(6H)-one
Homo sapiens
-
at pH 7.5 and 37°C
0.0012 - 0.0118
6-ethyl-6-[4-[(phenylsulfanyl)methyl]phenyl]-6,7-dihydropyrrolo[2,1-d][1,5]benzoxazepine
0.00015
6-indolin-N-yl-8-methylthio-9-(beta-D-ribofuranosyl)-purine
Homo sapiens
-
IC50: 150 nM
0.0012 - 0.061
6-[4-[(2-chloro-4-iodophenoxy)methyl]phenyl]-6-ethyl-6,7-dihydropyrrolo[2,1-d][1,5]benzoxazepine
0.0000045
6-[[6-(morpholin-4-yl)pyridin-3-yl]ethynyl]-5-(2-phenylethyl)pyrimidin-4-amine
Homo sapiens
pH and temperature not specified in the publication
0.0000025
6-[[6-(morpholin-4-yl)pyridin-3-yl]ethynyl]-5-(3-phenylpropyl)pyrimidin-4-amine
Homo sapiens
pH and temperature not specified in the publication
0.000038
6-[[6-(morpholin-4-yl)pyridin-3-yl]ethynyl]-5-(4-phenylbutyl)pyrimidin-4-amine
Homo sapiens
pH and temperature not specified in the publication
0.00012
6-[[6-(morpholin-4-yl)pyridin-3-yl]ethynyl]pyrimidin-4-amine hydrate (1:1)
Homo sapiens
pH and temperature not specified in the publication
0.0006
7-(3-dibenzo[b,d]furanyl)-7-deazaadenine
Mycobacterium tuberculosis
pH 8.0, 37°C
0.005
7-(beta-D-ribofuranosyl)-4-(1,3-thiazol-2-yl)-7H-pyrrolo[2,3-d]pyrimidine
Homo sapiens
-
IC50 above 0.005 mM, in 50 mM HEPES (pH 6.2), 10 mM KCl, 1 mM MgCl2, temperature not specified in the publication
0.002
7-(beta-D-ribofuranosyl)-4-(thiophen-2-yl)-7H-pyrrolo[2,3-d]pyrimidine
Homo sapiens
-
IC50 above 0.002 mM, in 50 mM HEPES (pH 6.2), 10 mM KCl, 1 mM MgCl2, temperature not specified in the publication
0.01
7-(beta-D-ribofuranosyl)-4-(thiophen-3-yl)-7H-pyrrolo[2,3-d]pyrimidine
Homo sapiens
-
IC50 above 0.01 mM, in 50 mM HEPES (pH 6.2), 10 mM KCl, 1 mM MgCl2, temperature not specified in the publication
0.001
8-acetylenyl-6-indolin-N-yl-9-(beta-D-ribofuranosyl)-purine
Homo sapiens
-
IC50: 1000 nM
0.0002
8-anilin-N-yl-6-indolin-N-yl-9-(5-deoxy-beta-D-ribofuranosyl)purine
Homo sapiens
-
IC50: 200 nM
0.000019
8-anilin-N-yl-6-indolin-N-yl-9-(beta-D-ribofuranosyl)-purine
Homo sapiens
-
IC50: 19 nM
2900
8-furan-2-yl-6-indolin-N-yl-9-(beta-D-ribofuranosyl)-purine
Homo sapiens
-
IC50: 2900 mM
0.0161
carbocyclic 6-(2,3,4-trimethylbenzylthio)inosine
Toxoplasma gondii
-
in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C
0.0186
carbocyclic 6-(2,4-dichlorobenzylthio)inosine
Toxoplasma gondii
-
in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C
0.0136
carbocyclic 6-(2-chloro-6-fluorobenzylthio)inosine
Toxoplasma gondii
-
in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C
0.02
carbocyclic 6-(2-chlorobenzylthio)inosine
Toxoplasma gondii
-
in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C
0.0389
carbocyclic 6-(2-fluorobenzylthio)inosine
Toxoplasma gondii
-
in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C
0.0197
carbocyclic 6-(2-methylbenzylthio)inosine
Toxoplasma gondii
-
in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C
0.0144
carbocyclic 6-(3,4-dichlorobenzylthio)inosine
Toxoplasma gondii
-
in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C
0.0238
carbocyclic 6-(3-methylbenzylthio)inosine
Toxoplasma gondii
-
in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C
0.0197
carbocyclic 6-(3-nitrobenzylthio)inosine
Toxoplasma gondii
-
in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C
0.0191
carbocyclic 6-(3-trifluoromethylbenzylthio)inosine
Toxoplasma gondii
-
in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C
0.0183
carbocyclic 6-(4-bromobenzylthio)inosine
Toxoplasma gondii
-
in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C
0.0145
carbocyclic 6-(4-chlorobenzylthio)inosine
Toxoplasma gondii
-
in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C
0.049
carbocyclic 6-(4-cyanobenzylthio)inosine
Toxoplasma gondii
-
in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C
0.0232
carbocyclic 6-(4-fluorobenzylthio)inosine
Toxoplasma gondii
-
in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C
0.0121
carbocyclic 6-(4-methoxybenzylthio)inosine
Toxoplasma gondii
-
in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C
0.0119
carbocyclic 6-(4-methylbenzylthio)inosine
Toxoplasma gondii
-
in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C
0.0146
carbocyclic 6-(4-methylsulfonylbenzylthio)inosine
Toxoplasma gondii
-
in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C
0.0428
carbocyclic 6-(4-nitrobenzylthio)inosine
Toxoplasma gondii
-
in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C
0.021
carbocyclic 6-(4-trifluoromethoxybenzylthio)inosine
Toxoplasma gondii
-
in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C
0.0128
carbocyclic 6-(p-methoxycarbonylbenzylthio)inosine
Toxoplasma gondii
-
in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C
0.0191
carbocyclic 6-benzylthioinosine
Toxoplasma gondii
-
in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C
0.000037 - 0.0014
cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(2-benzofuryl)-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
0.00011 - 0.004
cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(2-furyl)-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
0.00032 - 0.0047
cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(2-furyl)-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
0.00063 - 0.002
cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(2-thiazolyl)-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
0.00086 - 0.0024
cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(2-thienyl)-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
0.000083 - 0.0037
cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(2-thienyl)-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
0.0036 - 0.0039
cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(3-furyl)-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
0.0027 - 0.008
cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(3-furyl)-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
0.00097 - 0.0037
cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(3-thienyl)-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
0.00029 - 0.004
cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(3-thienyl)-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
0.0018 - 0.0065
cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(4-dibenzofuryl)-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
0.0031 - 0.025
cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(4-pyrazolyl)-7 H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
0.0294
P1,P5-di(adenosine-5')-pentaphosphate
Trypanosoma brucei
pH and temperature not specified in the publication
0.0008
6-(4-[[(2-chlorophenyl)sulfanyl]methyl]phenyl)-6-ethyl-6,7-dihydropyrrolo[2,1-d][1,5]benzoxazepine
Homo sapiens
mutant Q78A, pH 7.5, 37°C
0.001
6-(4-[[(2-chlorophenyl)sulfanyl]methyl]phenyl)-6-ethyl-6,7-dihydropyrrolo[2,1-d][1,5]benzoxazepine
Homo sapiens
wild-type, pH 7.5, 37°C
0.003
6-(4-[[(2-chlorophenyl)sulfanyl]methyl]phenyl)-6-ethyl-6,7-dihydropyrrolo[2,1-d][1,5]benzoxazepine
Homo sapiens
mutant H107A, pH 7.5, 37°C
0.0036
6-(4-[[(2-chlorophenyl)sulfanyl]methyl]phenyl)-6-ethyl-6,7-dihydropyrrolo[2,1-d][1,5]benzoxazepine
Homo sapiens
mutant Q74A, pH 7.5, 37°C
0.0037
6-(4-[[(2-chlorophenyl)sulfanyl]methyl]phenyl)-6-ethyl-6,7-dihydropyrrolo[2,1-d][1,5]benzoxazepine
Homo sapiens
mutant K341A, pH 7.5, 37°C
0.0133
6-(4-[[(2-chlorophenyl)sulfanyl]methyl]phenyl)-6-ethyl-6,7-dihydropyrrolo[2,1-d][1,5]benzoxazepine
Homo sapiens
mutant F338A, pH 7.5, 37°C
0.0204
6-benzylthioinosine
Toxoplasma gondii
-
in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C
0.0012
6-ethyl-6-[4-[(phenylsulfanyl)methyl]phenyl]-6,7-dihydropyrrolo[2,1-d][1,5]benzoxazepine
Homo sapiens
wild-type, pH 7.5, 37°C
0.002
6-ethyl-6-[4-[(phenylsulfanyl)methyl]phenyl]-6,7-dihydropyrrolo[2,1-d][1,5]benzoxazepine
Homo sapiens
mutant Q78A, pH 7.5, 37°C
0.0026
6-ethyl-6-[4-[(phenylsulfanyl)methyl]phenyl]-6,7-dihydropyrrolo[2,1-d][1,5]benzoxazepine
Homo sapiens
mutant H107A, pH 7.5, 37°C
0.0035
6-ethyl-6-[4-[(phenylsulfanyl)methyl]phenyl]-6,7-dihydropyrrolo[2,1-d][1,5]benzoxazepine
Homo sapiens
mutant K341A, pH 7.5, 37°C
0.0064
6-ethyl-6-[4-[(phenylsulfanyl)methyl]phenyl]-6,7-dihydropyrrolo[2,1-d][1,5]benzoxazepine
Homo sapiens
mutant Q74A, pH 7.5, 37°C
0.0118
6-ethyl-6-[4-[(phenylsulfanyl)methyl]phenyl]-6,7-dihydropyrrolo[2,1-d][1,5]benzoxazepine
Homo sapiens
mutant F338A, pH 7.5, 37°C
0.0012
6-[4-[(2-chloro-4-iodophenoxy)methyl]phenyl]-6-ethyl-6,7-dihydropyrrolo[2,1-d][1,5]benzoxazepine
Homo sapiens
wild-type, pH 7.5, 37°C
0.0023
6-[4-[(2-chloro-4-iodophenoxy)methyl]phenyl]-6-ethyl-6,7-dihydropyrrolo[2,1-d][1,5]benzoxazepine
Homo sapiens
mutant Q78A, pH 7.5, 37°C
0.0033
6-[4-[(2-chloro-4-iodophenoxy)methyl]phenyl]-6-ethyl-6,7-dihydropyrrolo[2,1-d][1,5]benzoxazepine
Homo sapiens
mutant H107A, pH 7.5, 37°C
0.0198
6-[4-[(2-chloro-4-iodophenoxy)methyl]phenyl]-6-ethyl-6,7-dihydropyrrolo[2,1-d][1,5]benzoxazepine
Homo sapiens
mutant K341A, pH 7.5, 37°C
0.0203
6-[4-[(2-chloro-4-iodophenoxy)methyl]phenyl]-6-ethyl-6,7-dihydropyrrolo[2,1-d][1,5]benzoxazepine
Homo sapiens
mutant Q74A, pH 7.5, 37°C
0.061
6-[4-[(2-chloro-4-iodophenoxy)methyl]phenyl]-6-ethyl-6,7-dihydropyrrolo[2,1-d][1,5]benzoxazepine
Homo sapiens
mutant F338A, pH 7.5, 37°C
0.000037
cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(2-benzofuryl)-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
Homo sapiens
-
in 50 mM HEPES (pH 6.2), 10 mM KCl, 1 mM MgCl2, temperature not specified in the publication
0.0014
cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(2-benzofuryl)-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
Mycobacterium tuberculosis
-
in 50 mM Tris-HCl (pH 8.0), 10 mM KCl, 10 mM MgCl2, temperature not specified in the publication
0.00011
cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(2-furyl)-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
Homo sapiens
-
in 50 mM HEPES (pH 6.2), 10 mM KCl, 1 mM MgCl2, temperature not specified in the publication
0.004
cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(2-furyl)-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
Mycobacterium tuberculosis
-
in 50 mM Tris-HCl (pH 8.0), 10 mM KCl, 10 mM MgCl2, temperature not specified in the publication
0.00032
cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(2-furyl)-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
Homo sapiens
-
in 50 mM HEPES (pH 6.2), 10 mM KCl, 1 mM MgCl2, temperature not specified in the publication
0.0047
cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(2-furyl)-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
Mycobacterium tuberculosis
-
in 50 mM Tris-HCl (pH 8.0), 10 mM KCl, 10 mM MgCl2, temperature not specified in the publication
0.00063
cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(2-thiazolyl)-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
Homo sapiens
-
in 50 mM HEPES (pH 6.2), 10 mM KCl, 1 mM MgCl2, temperature not specified in the publication
0.002
cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(2-thiazolyl)-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
Mycobacterium tuberculosis
-
in 50 mM Tris-HCl (pH 8.0), 10 mM KCl, 10 mM MgCl2, temperature not specified in the publication
0.00086
cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(2-thienyl)-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
Homo sapiens
-
in 50 mM HEPES (pH 6.2), 10 mM KCl, 1 mM MgCl2, temperature not specified in the publication
0.0024
cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(2-thienyl)-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
Mycobacterium tuberculosis
-
in 50 mM Tris-HCl (pH 8.0), 10 mM KCl, 10 mM MgCl2, temperature not specified in the publication
0.000083
cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(2-thienyl)-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
Homo sapiens
-
in 50 mM HEPES (pH 6.2), 10 mM KCl, 1 mM MgCl2, temperature not specified in the publication
0.0037
cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(2-thienyl)-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
Mycobacterium tuberculosis
-
in 50 mM Tris-HCl (pH 8.0), 10 mM KCl, 10 mM MgCl2, temperature not specified in the publication
0.0036
cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(3-furyl)-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
Homo sapiens
-
in 50 mM HEPES (pH 6.2), 10 mM KCl, 1 mM MgCl2, temperature not specified in the publication
0.0039
cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(3-furyl)-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
Mycobacterium tuberculosis
-
in 50 mM Tris-HCl (pH 8.0), 10 mM KCl, 10 mM MgCl2, temperature not specified in the publication
0.0027
cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(3-furyl)-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
Homo sapiens
-
in 50 mM HEPES (pH 6.2), 10 mM KCl, 1 mM MgCl2, temperature not specified in the publication
0.008
cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(3-furyl)-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
Mycobacterium tuberculosis
-
in 50 mM Tris-HCl (pH 8.0), 10 mM KCl, 10 mM MgCl2, temperature not specified in the publication
0.00097
cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(3-thienyl)-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
Homo sapiens
-
in 50 mM HEPES (pH 6.2), 10 mM KCl, 1 mM MgCl2, temperature not specified in the publication
0.0037
cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(3-thienyl)-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
Mycobacterium tuberculosis
-
in 50 mM Tris-HCl (pH 8.0), 10 mM KCl, 10 mM MgCl2, temperature not specified in the publication
0.00029
cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(3-thienyl)-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
Homo sapiens
-
in 50 mM HEPES (pH 6.2), 10 mM KCl, 1 mM MgCl2, temperature not specified in the publication
0.004
cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(3-thienyl)-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
Mycobacterium tuberculosis
-
in 50 mM Tris-HCl (pH 8.0), 10 mM KCl, 10 mM MgCl2, temperature not specified in the publication
0.0018
cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(4-dibenzofuryl)-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
Homo sapiens
-
in 50 mM HEPES (pH 6.2), 10 mM KCl, 1 mM MgCl2, temperature not specified in the publication
0.0065
cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(4-dibenzofuryl)-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
Mycobacterium tuberculosis
-
in 50 mM Tris-HCl (pH 8.0), 10 mM KCl, 10 mM MgCl2, temperature not specified in the publication
0.0031
cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(4-pyrazolyl)-7 H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
Homo sapiens
-
in 50 mM HEPES (pH 6.2), 10 mM KCl, 1 mM MgCl2, temperature not specified in the publication
0.025
cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(4-pyrazolyl)-7 H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
Mycobacterium tuberculosis
-
IC50 above 0.025 mM, in 50 mM Tris-HCl (pH 8.0), 10 mM KCl, 10 mM MgCl2, temperature not specified in the publication
0.0161
pyrimethamine
Toxoplasma gondii
-
in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C
0.0273
Sulfadiazine
Toxoplasma gondii
-
in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2; 1 mM dithiothreitol, 25 mM NaF, at 37°C
