2.7.1.20: adenosine kinase

This is an abbreviated version!
For detailed information about adenosine kinase, go to the full flat file.

Word Map on EC 2.7.1.20

2.7.1.20

nucleoside

deaminase

purine

amp

adenylate

inosine

salvage

hypoxanthine

epilepsy

phosphoribosyltransferase

5'-nucleotidase

5-iodotubercidin

riboside

deoxyadenosine

s-adenosylhomocysteine

deoxycytidine

aicar

anticonvulsant

tubercidin

dipyridamole

neuromodulator

ehna

2\'-deoxycoformycin

ecto-5\'-nucleotidase

ribokinase

erythro-9-2-hydroxy-3-nonyl

adenosinergic

6-methylmercaptopurine

3hadenosine

2-chloroadenosine

coformycin

nitrobenzylthioinosine

epileptogenesis

hypoxanthine-guanine

transmethylation

adenosine-induced

hgprt

kinase-deficient

2'-deoxyadenosine

adenosine-mediated

3.5.4.4

deoxycoformycin

non-nucleoside

analysis

2.4.2.8

9-beta-d-arabinofuranosyladenine

n6-cyclopentyladenosine

erythro-9-2-hydroxy-3-nonyladenine

dado

ara-a

medicine

diagnostics

rephosphorylation

pharmacology

Reaction

Synonyms

adenosine kinase (phosphorylating), ADK, AdK-L, AdK-S, Ado kinase, AdoK, AK, ATP:adenosine 5'-phosphotransferase, CpAK, hADK, kinase, adenosine (phosphorylating), LdAdK, MGG_06270, Rv2202c, Tb927.6.2360, TbAK

ECTree

2 Transferases

2.7 Transferring phosphorus-containing groups

2.7.1 Phosphotransferases with an alcohol group as acceptor

2.7.1.20 adenosine kinase

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Results	in table
39	Activating Compound
6615	AA Sequence
15	Application
1	CAS Registry Number
36	Cloned(Commentary)
1	Cofactor
21	Crystallization (Commentary)
990	Disease/ Diagnostics
2	Expression
13	General Information
19	General Stability
182	IC50 Value
555	Inhibitors
18	kcat/KM [mM/s]
87	Ki Value [mM]
164	KM Value [mM]
20	Localization
179	Metals/Ions
43	Molecular Weight [Da]
47	Natural Substrates/ Products (Substrates)
676	Organism
5	Pathway
51	PDB ID
45	pH Optimum
12	pH Range
7	pH Stability
4	pI Value
1	Posttranslational Modification
29	Protein Variants
52	Purification (Commentary)
12	Reaction
1	Reaction Type
161	Reference
135	Source Tissue
42	Specific Activity [micromol/min/mg]
21	Storage Stability
347	Substrates and Products (Substrate)
32	Subunits
66	Synonyms
1	Systematic Name
31	Temperature Optimum [°C]
1	Temperature Range [°C]
10	Temperature Stability [°C]
68	Turnover Number [1/s]

General Stability

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General Stability on EC 2.7.1.20 - adenosine kinase

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0.15 M KCl stabilizes, rapid inactivation at low salt concentrations, DTT reverses

Rattus norvegicus

641090

at 1 mg protein/ml stable upon repeated freeze-thawing

Rattus norvegicus

641089

ATP or GTP stabilizes during gel filtration

Trypanosoma cruzi

641096

bovine serum albumin stabilizes

4 entries

does not withstand dialysis against Tris-dithioerythritol buffer, pH 8, with or without 1 mM ATP

Trypanosoma cruzi

641096

glycerol stabilizes

Entamoeba histolytica

641074

GSH, 2-mercaptoethanol, Mg2+ and adenosine do not stabilize

Oryctolagus cuniculus

641078

purified enzyme preparation is stable in the concentrated form

Homo sapiens

641083

rapid inactivation in aqueous solution

Oryctolagus cuniculus

641078

repeated freezing inactivates

2 entries

stable when thawed and refrozen

Homo sapiens

641084

unstable upon ammonium sulfate fractionation or adsorption on aluminium oxide or calcium phosphate gel

Oryctolagus cuniculus

641078

very unstable in dilute solution. Addition of albumin to reaction mixture in dilute enzyme preparations increases activity. MgATP2-, 1 mM, adenosine 5 mM, and 20% glycerol stabilize on a short term basis at 4ºC. Repeated freeze-thawing inactivates dilute enzyme solutions

Homo sapiens

641082