2.7.1.20: adenosine kinase
This is an abbreviated version!
For detailed information about adenosine kinase, go to the full flat file.
Word Map on EC 2.7.1.20
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2.7.1.20
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nucleoside
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deaminase
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purine
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amp
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adenylate
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inosine
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salvage
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hypoxanthine
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epilepsy
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phosphoribosyltransferase
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5'-nucleotidase
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5-iodotubercidin
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riboside
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deoxyadenosine
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s-adenosylhomocysteine
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deoxycytidine
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aicar
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anticonvulsant
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tubercidin
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dipyridamole
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neuromodulator
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ehna
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2\'-deoxycoformycin
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ecto-5\'-nucleotidase
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ribokinase
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erythro-9-2-hydroxy-3-nonyl
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adenosinergic
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6-methylmercaptopurine
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3hadenosine
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2-chloroadenosine
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coformycin
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nitrobenzylthioinosine
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epileptogenesis
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hypoxanthine-guanine
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transmethylation
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adenosine-induced
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hgprt
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kinase-deficient
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2'-deoxyadenosine
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adenosine-mediated
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3.5.4.4
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deoxycoformycin
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non-nucleoside
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analysis
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2.4.2.8
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9-beta-d-arabinofuranosyladenine
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n6-cyclopentyladenosine
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erythro-9-2-hydroxy-3-nonyladenine
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dado
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ara-a
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medicine
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diagnostics
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rephosphorylation
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pharmacology
- 2.7.1.20
- nucleoside
- deaminase
- purine
- amp
- adenylate
- inosine
-
salvage
- hypoxanthine
- epilepsy
-
phosphoribosyltransferase
- 5'-nucleotidase
- 5-iodotubercidin
- riboside
- deoxyadenosine
- s-adenosylhomocysteine
- deoxycytidine
- aicar
-
anticonvulsant
- tubercidin
- dipyridamole
-
neuromodulator
- ehna
-
2\'-deoxycoformycin
-
ecto-5\'-nucleotidase
- ribokinase
-
erythro-9-2-hydroxy-3-nonyl
-
adenosinergic
- 6-methylmercaptopurine
-
3hadenosine
- 2-chloroadenosine
- coformycin
-
nitrobenzylthioinosine
-
epileptogenesis
-
hypoxanthine-guanine
-
transmethylation
-
adenosine-induced
- hgprt
-
kinase-deficient
- 2'-deoxyadenosine
-
adenosine-mediated
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3.5.4.4
- deoxycoformycin
-
non-nucleoside
- analysis
-
2.4.2.8
- 9-beta-d-arabinofuranosyladenine
-
n6-cyclopentyladenosine
-
erythro-9-2-hydroxy-3-nonyladenine
-
dado
- ara-a
- medicine
- diagnostics
-
rephosphorylation
- pharmacology
Reaction
Synonyms
adenosine kinase (phosphorylating), ADK, AdK-L, AdK-S, Ado kinase, AdoK, AK, ATP:adenosine 5'-phosphotransferase, CpAK, hADK, kinase, adenosine (phosphorylating), LdAdK, MGG_06270, Rv2202c, Tb927.6.2360, TbAK
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General Information on EC 2.7.1.20 - adenosine kinase
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GENERAL INFORMATION 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
drug target
adenosine kinase inhibitors raise endogenous adenosine levels, particularly in disease states, and have potential for treatment of seizures, neurodegeneration, and inflammation
malfunction
metabolism
physiological function
malfunction
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silencing of adenosine kinase leads to impaired root growth, small, crinkled rosette leaves, and reduced apical dominance. ADK-deficient tissues exhibit increased Arabidopsis Response Regulator5 and Arabidopsis Response Regulator7 expression
malfunction
case report of a patient with adenosine kinase deletion with phenotypes (schizophrenia, parkinsonism, epilepsy) that are predicted when adenosine kinase function is disrupted
malfunction
disruption of adenosine kinase causes spontaneous cardiac hypertrophy
metabolism
adenosine kinase (ADK) is the first enzyme in the adenosine remediation pathway that catalyzes adenosine phosphorylation into adenosine monophosphate, thus regulating adenosine homeostasis in cells. RNA interference reveals the downregulation of the enzyme (BmADK) decreases ATG-8, caspase-9, Ec-R, E74A, and Br-C expression, indicating it is likely involved in 20E signaling, apoptosis, and autophagy to regulate silk gland degeneration and silkworm metamorphosis
metabolism
essential enzyme of Mycobacterium tuberculosis and forms part of the purine salvage pathway within mycobacteria
metabolism
the enzyme is involved in myocardial adenosine metabolism. Cardiomyocyte adenosine kinase expression attenuates pressure overload induced hypertrophy. Aadenosine kinase regulates cardiac mTORC1 and p44/42 ERK MAP kinase signaling. Adenosine metabolism by adenosine kinase diminishes detyrosinated microtubules
metabolism
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essential enzyme of Mycobacterium tuberculosis and forms part of the purine salvage pathway within mycobacteria
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physiological function
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adenosine kinase contributes to cytokinin homeostasis in vivo
physiological function
adenosine kinase shows anti-freezing activity when expressed in yeast
physiological function
the expression of adenosine kinase in ribavirin-sensitive Orl-8 cells is significantly higher than that in ribavirin-resistant Or-6 cells harboring hepatitis C virus RNA. Ectopic adenosine kinase expression in Or-6 cells converts them from an ribavirin-resistant to an ribavirin-sensitive phenotype, and inhibition of adenosine kinase abolishes the activity of ribavirin. The differential adenosine kinase expression between is not the result of genetic polymorphisms in the adeosine kinase gene promoter region and is not mediated by a microRNA control mechanism. The 5' untranslated region of adenosine kinase messenger RNA in Orl-8 cells is longer than that in OR6 cells, and only a long 5' UTR possesses internal ribosome entry site activity
physiological function
intracellular adenosine, which is controlled by the key molecular regulator adenosine kinase, influences endothelial inflammation and vascular inflammatory diseases
physiological function
Pyricularia oryzae ATCC MYA-4617
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adenosine kinase shows anti-freezing activity when expressed in yeast
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