2.7.1.20: adenosine kinase
This is an abbreviated version!
For detailed information about adenosine kinase, go to the full flat file.
Word Map on EC 2.7.1.20
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2.7.1.20
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nucleoside
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deaminase
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purine
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amp
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adenylate
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inosine
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salvage
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hypoxanthine
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epilepsy
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phosphoribosyltransferase
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5'-nucleotidase
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5-iodotubercidin
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riboside
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deoxyadenosine
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s-adenosylhomocysteine
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deoxycytidine
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aicar
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anticonvulsant
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tubercidin
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dipyridamole
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neuromodulator
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ehna
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2\'-deoxycoformycin
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ecto-5\'-nucleotidase
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ribokinase
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erythro-9-2-hydroxy-3-nonyl
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adenosinergic
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6-methylmercaptopurine
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3hadenosine
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2-chloroadenosine
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coformycin
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nitrobenzylthioinosine
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epileptogenesis
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hypoxanthine-guanine
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transmethylation
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adenosine-induced
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hgprt
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kinase-deficient
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2'-deoxyadenosine
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adenosine-mediated
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3.5.4.4
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deoxycoformycin
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non-nucleoside
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analysis
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2.4.2.8
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9-beta-d-arabinofuranosyladenine
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n6-cyclopentyladenosine
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erythro-9-2-hydroxy-3-nonyladenine
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dado
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ara-a
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medicine
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diagnostics
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rephosphorylation
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pharmacology
- 2.7.1.20
- nucleoside
- deaminase
- purine
- amp
- adenylate
- inosine
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salvage
- hypoxanthine
- epilepsy
-
phosphoribosyltransferase
- 5'-nucleotidase
- 5-iodotubercidin
- riboside
- deoxyadenosine
- s-adenosylhomocysteine
- deoxycytidine
- aicar
-
anticonvulsant
- tubercidin
- dipyridamole
-
neuromodulator
- ehna
-
2\'-deoxycoformycin
-
ecto-5\'-nucleotidase
- ribokinase
-
erythro-9-2-hydroxy-3-nonyl
-
adenosinergic
- 6-methylmercaptopurine
-
3hadenosine
- 2-chloroadenosine
- coformycin
-
nitrobenzylthioinosine
-
epileptogenesis
-
hypoxanthine-guanine
-
transmethylation
-
adenosine-induced
- hgprt
-
kinase-deficient
- 2'-deoxyadenosine
-
adenosine-mediated
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3.5.4.4
- deoxycoformycin
-
non-nucleoside
- analysis
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2.4.2.8
- 9-beta-d-arabinofuranosyladenine
-
n6-cyclopentyladenosine
-
erythro-9-2-hydroxy-3-nonyladenine
-
dado
- ara-a
- medicine
- diagnostics
-
rephosphorylation
- pharmacology
Reaction
Synonyms
adenosine kinase (phosphorylating), ADK, AdK-L, AdK-S, Ado kinase, AdoK, AK, ATP:adenosine 5'-phosphotransferase, CpAK, hADK, kinase, adenosine (phosphorylating), LdAdK, MGG_06270, Rv2202c, Tb927.6.2360, TbAK
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analysis
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the coexpression of adenosine kinase TbAK and adenosine transporter gene TbAT1 in Saccharomyces cerevisiae ado1 ade2 double mutants proves to be a convenient tool for testing nucleoside analogues for uptake and activation by Trypanosoma brucei adenosine salvage enzymes
diagnostics
a rapid and sensitive colorimetric assay for the determination of adenosine kinase activity is developed
medicine
pharmacology
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the enzyme is an excellent target for chemotherapy with 6-substituted purine nucleosides being potential selective antitoxoplasmic agents
medicine
adenosine kinase represents a potential chemotherapeutic target for the treatment of Toxoplasma gondii infections
medicine
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the enzyme is a rational therapeutic target to enhance neuroprotection in ischemia
medicine
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ADK has emerged as a novel target to predict and to prevent epileptogenesis. High levels of ADK expression (e.g. as a long-term consequence of traumatic brain injury) are expected to be predictive for subsequent epileptogenesis. This means that the determination of ADK expression levels in brain, e.g. by using ADK-selective PET or SPECT ligands, has high diagnostic value. On the other hand, prevention of epileptogenesis by focal reconstitution of the adenosine system is an important therapeutic goal
medicine
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astrocyte-based ADK provides a critical link between astrogliosis and neuronal dysfunction in epilepsy
medicine
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lentiviral expression of anti-adenosine kinase miRNA constitutes a versatile tool to generate therapeutically effective adenosine releasing mesenchymal stem cells, thus representing a model system to generate patient identical autologous adult stem cell grafts
medicine
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pathologic overexpression of ADK as in epilepsy may also render the brain more susceptible to injury from ischemia. Consequently, ADK emerges as a rational therapeutic target to enhance neuroprotection
medicine
siRNAs transfected into cells can work efficiently to regulate gene expression in Toxoplasma gondii. The application of siRNA in interrupting gene expression in Toxoplasma gondii would be useful for elucidating gene function as a step toward development of antitoxoplasmasis vaccines and therapeutic reagents
medicine
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Toxoplasma gondii adenosine kinase is an excellent target for chemotherapy and 7-deaza-6-benzylthioinosines are potential antitoxoplasmic agents
medicine
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transfection of dsRNAs into cells can efficiently regulate gene expression in Toxoplasma gondii. Application of dsRNA to disrupt gene expression in Toxoplasma gondii would be useful for elucidating gene function as a step towards the development of therapeutic reagents
medicine
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upregulation of adenosine kinase is a common pathologic hallmark of Rasmussen encephalitis. Focal astrogliosis and marked expression of adenosine kinase are observed in the lesions of Rasmussen encephalitis. Significantly greater adenosine kinase expression in Rasmussen encephalitis versus controls and greater enzymatic activity for adenosine kinase are found
enzyme is a target for drug development in tuberculosis treatment of humans due to the structural and substrate specificity differences of human and mycobacterial enzymes, overview
pharmacology
Mycobacterium tuberculosis H37Ra / ATCC 25177
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enzyme is a target for drug development in tuberculosis treatment of humans due to the structural and substrate specificity differences of human and mycobacterial enzymes, overview
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