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2.7.1.199: protein-Npi-phosphohistidine-D-glucose phosphotransferase

This is an abbreviated version!
For detailed information about protein-Npi-phosphohistidine-D-glucose phosphotransferase, go to the full flat file.

Word Map on EC 2.7.1.199

Reaction

[protein]-Npi-phospho-L-histidine
+
D-glucose[side 1]
=
[protein]-L-histidine
 +
D-glucose 6-phosphate[side 2]

Synonyms

D-glucose PTS permease, D-glucose transporter, domain A of enzyme II, EC 2.7.1.69, ecIICBGlc, EIIAGlc, EIIBCA, EIICBAGlc1, EIICBAGlc2, EIICBGlc, EIIGlc, enzyme II-BGlc, enzyme IICBGlc, enzyme IIGlc, ExuT, glcA, glucose permease, glucose PTS permease, glucose specific transporter, glucose transporter, glucose-permease, glucose-PTS transporter, glucose-specific carrier, glucose-specific EII complex, glucose-specific enzyme I1, glucose-specific enzyme II, glucose-specific enzyme IICBA PTS component, glucose-specific permease, glucose-specific phosphotransferase system, glucose-specific PTS enzyme II, glucose-specific PTS permease, glucose-specific transporter of phosphoenolpyruvate:carbohydrate phosphotransferase system, glucose-specific transporter of the phosphotransferase system, high affinity Glc transporter, II-BGlc, IIAGlc, IIBCGlc, IIBGlc, IICB, IICBA Glc, IICBGlc, IICglc, IIGlc, non-PTS sugar transporter, phosphoenolpyruvate-dependent glucose phosphotransferase system, phosphoenolpyruvate-dependent glucose-phosphotransferase system, PTS IIC glucose transporter, PtsG, ptsG-I, PTSGlc, sugar permease

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.199 protein-Npi-phosphohistidine-D-glucose phosphotransferase

Expression

Expression on EC 2.7.1.199 - protein-Npi-phosphohistidine-D-glucose phosphotransferase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
enzyme expression is repressed by the DeoR-type regulator SugR, RamB, and GlxR
expression of the major ptsG transcript is induced by repressed by the Mlc protein
-
in the absence of glucose, ptsG expression is repressed by the repressor Mlc, while in the presence of glucose Mlc is inactivated by binding to the dephosphorylated EIIBGlc domain of the EIICBGlc during glucose transport
-
phospho-ArcA represses ptsG P1 transcription by decreasing the cAMP receptor protein binding
-
protein YeeI is involved in the regulation of gene expression by inactivating repressor Ml. The enzyme synthesis is increased 6.2fold after addition of 0.2% (w/v) D-glucose
-
the enzyme expression is higher in D-glucose media than in glycerol. A mutation in the mlc gene greatly enhances enzyme expression in a glycerol-grown culture but has no effect on enzyme expression during growth on D-glucose
-
the presence of GlcT protein enables constitutive expression of the glcA gene
-
the transcriptional regulators GntR1 and GntR2 activate the enzyme expression
the umgC mutation (which allows a strain mutated in the mannose phosphotransferase system to grow on glucosamine) enhances enzyme mRNA levels
transcription of ptsG is regulated by the repressor Mlc