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2.7.1.189: autoinducer-2 kinase

This is an abbreviated version!
For detailed information about autoinducer-2 kinase, go to the full flat file.

Word Map on EC 2.7.1.189

Reaction

ATP
+
(S)-4,5-dihydroxypentane-2,3-dione
=
ADP
 +
(S)-4-hydroxypentane-2,3-dione 5-phosphate

Synonyms

AI-2 kinase, AI-2 processing kinase, Lsr kinase, lsrK, LsrK kinase

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.189 autoinducer-2 kinase

Inhibitors

Inhibitors on EC 2.7.1.189 - autoinducer-2 kinase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,2-dihydroxydecane-3,4-dione
-
-
1,2-dihydroxyheptane-3,4-dione
-
-
1,2-dihydroxyhexane-3,4-dione
-
weak inhibition
1,2-dihydroxyoctane-3,4-dione
-
-
2,3,4,5-tetrachloro-6-(2,3,4,5-tetrachloroanilino)benzoic acid
-
2-(1,3-benzothiazol-2-yl)-5-(5-methylfuran-2-yl)-3-oxopentanenitrile
-
2-(3-chloro-2-methylanilino)benzoic acid
-
2-[2-chloro-5-(trifluoromethyl)anilino]-5-methoxybenzoic acid
-
7-dehydroxypryogallin-4-carboxylic acid
-
HPr
a phosphocarrier protein central to the sugar phosphotransferase system of Escherichia coli. HPr copurifies with LsrK. LsrK activity is inhibited when bound to HPr. HPr inhibited LsrK activity in a mixed manner of competitive and uncompetitive, not via competitive or uncompetitive inhibition alone. Phosphorylation of HPr reduces its inhibitory effect on LsrK
-
HPr H15A
the HPr H15A mutant displays almost no inhibition of the enzyme
-
HPr H15E
the HPr H15E mutant displays several times lower inhibition compared to the wild-type
-
rosolic acid
rosolic acid positively stabilizes His-LsrK in thermal shift at high concentrations, suggesting a low affnity binding interaction between the two, high target specificity
[(3-chloro-2-methylphenyl)amino]benzoic acid
-
additional information
-