2.7.1.186: mevalonate-3-phosphate 5-kinase
This is an abbreviated version!
For detailed information about mevalonate-3-phosphate 5-kinase, go to the full flat file.
Reaction
Synonyms
M3P5K, MVA-3-P 5-kinase, Ta0762
ECTree
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General Information
General Information on EC 2.7.1.186 - mevalonate-3-phosphate 5-kinase
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evolution
metabolism
physiological function
mevalonate 3-phosphate 5-kinase is an enzyme involved in the modified mevalonate pathway specific to limited species of thermophilic archaea
evolution
-
mevalonate 3-phosphate 5-kinase is an enzyme involved in the modified mevalonate pathway specific to limited species of thermophilic archaea
-
evolution
-
mevalonate 3-phosphate 5-kinase is an enzyme involved in the modified mevalonate pathway specific to limited species of thermophilic archaea
-
evolution
-
mevalonate 3-phosphate 5-kinase is an enzyme involved in the modified mevalonate pathway specific to limited species of thermophilic archaea
-
evolution
-
mevalonate 3-phosphate 5-kinase is an enzyme involved in the modified mevalonate pathway specific to limited species of thermophilic archaea
-
mevalonate 3-kinase plays a key role in a recently discovered modified mevalonate pathway specific to thermophilic archaea of the order Thermoplasmatales, pathway overview. In the pathway called modified MVA pathway II, mevalonate (MVA) is phosphorylated at the 3-hydroxyl group to yield 3-phosphomevalonate (MVA-3-P) by the action of mevalonate 3-kinase (M3K, EC 2.7.1.185) rather than at the 5-hydroxyl group as in the reaction of MVK (EC 2.7.4.2). M3K is also homologous to diphosphomevalonate decarboxylase (DMD). After the formation of MVA-3-P, another kinase, MVA-3-P 5-kinase (M3P5K), catalyzes its 5-phosphorylation, and a subsequent decarboxylation is catalyzed by another DMD homologue, 3,5-bisphosphomevalonate decarboxylase (BMD), to give isopentenyl phosphate (IP). IP is then phosphorylated by isopentenyl phosphate kinase (IPK) to yield isopentenyl diphosphate (IPP)
metabolism
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mevalonate 3-kinase plays a key role in a recently discovered modified mevalonate pathway specific to thermophilic archaea of the order Thermoplasmatales, pathway overview. In the pathway called modified MVA pathway II, mevalonate (MVA) is phosphorylated at the 3-hydroxyl group to yield 3-phosphomevalonate (MVA-3-P) by the action of mevalonate 3-kinase (M3K, EC 2.7.1.185) rather than at the 5-hydroxyl group as in the reaction of MVK (EC 2.7.4.2). M3K is also homologous to diphosphomevalonate decarboxylase (DMD). After the formation of MVA-3-P, another kinase, MVA-3-P 5-kinase (M3P5K), catalyzes its 5-phosphorylation, and a subsequent decarboxylation is catalyzed by another DMD homologue, 3,5-bisphosphomevalonate decarboxylase (BMD), to give isopentenyl phosphate (IP). IP is then phosphorylated by isopentenyl phosphate kinase (IPK) to yield isopentenyl diphosphate (IPP)
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metabolism
-
mevalonate 3-kinase plays a key role in a recently discovered modified mevalonate pathway specific to thermophilic archaea of the order Thermoplasmatales, pathway overview. In the pathway called modified MVA pathway II, mevalonate (MVA) is phosphorylated at the 3-hydroxyl group to yield 3-phosphomevalonate (MVA-3-P) by the action of mevalonate 3-kinase (M3K, EC 2.7.1.185) rather than at the 5-hydroxyl group as in the reaction of MVK (EC 2.7.4.2). M3K is also homologous to diphosphomevalonate decarboxylase (DMD). After the formation of MVA-3-P, another kinase, MVA-3-P 5-kinase (M3P5K), catalyzes its 5-phosphorylation, and a subsequent decarboxylation is catalyzed by another DMD homologue, 3,5-bisphosphomevalonate decarboxylase (BMD), to give isopentenyl phosphate (IP). IP is then phosphorylated by isopentenyl phosphate kinase (IPK) to yield isopentenyl diphosphate (IPP)
-
metabolism
-
mevalonate 3-kinase plays a key role in a recently discovered modified mevalonate pathway specific to thermophilic archaea of the order Thermoplasmatales, pathway overview. In the pathway called modified MVA pathway II, mevalonate (MVA) is phosphorylated at the 3-hydroxyl group to yield 3-phosphomevalonate (MVA-3-P) by the action of mevalonate 3-kinase (M3K, EC 2.7.1.185) rather than at the 5-hydroxyl group as in the reaction of MVK (EC 2.7.4.2). M3K is also homologous to diphosphomevalonate decarboxylase (DMD). After the formation of MVA-3-P, another kinase, MVA-3-P 5-kinase (M3P5K), catalyzes its 5-phosphorylation, and a subsequent decarboxylation is catalyzed by another DMD homologue, 3,5-bisphosphomevalonate decarboxylase (BMD), to give isopentenyl phosphate (IP). IP is then phosphorylated by isopentenyl phosphate kinase (IPK) to yield isopentenyl diphosphate (IPP)
-
metabolism
-
mevalonate 3-kinase plays a key role in a recently discovered modified mevalonate pathway specific to thermophilic archaea of the order Thermoplasmatales, pathway overview. In the pathway called modified MVA pathway II, mevalonate (MVA) is phosphorylated at the 3-hydroxyl group to yield 3-phosphomevalonate (MVA-3-P) by the action of mevalonate 3-kinase (M3K, EC 2.7.1.185) rather than at the 5-hydroxyl group as in the reaction of MVK (EC 2.7.4.2). M3K is also homologous to diphosphomevalonate decarboxylase (DMD). After the formation of MVA-3-P, another kinase, MVA-3-P 5-kinase (M3P5K), catalyzes its 5-phosphorylation, and a subsequent decarboxylation is catalyzed by another DMD homologue, 3,5-bisphosphomevalonate decarboxylase (BMD), to give isopentenyl phosphate (IP). IP is then phosphorylated by isopentenyl phosphate kinase (IPK) to yield isopentenyl diphosphate (IPP)
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mevalonate-3-kinase and mevalonate-3-phosphate-5-kinase act sequentially in a putative alternate mevalonate pathway in Thermoplasma acidophilum
physiological function
mevalonate 3-phosphate 5-kinase catalyzes the ATP-dependent 5-phosphorylation of 3-phosphomevalonate
physiological function
-
mevalonate 3-phosphate 5-kinase catalyzes the ATP-dependent 5-phosphorylation of 3-phosphomevalonate
-
physiological function
-
mevalonate 3-phosphate 5-kinase catalyzes the ATP-dependent 5-phosphorylation of 3-phosphomevalonate
-
physiological function
-
mevalonate 3-phosphate 5-kinase catalyzes the ATP-dependent 5-phosphorylation of 3-phosphomevalonate
-
physiological function
-
mevalonate 3-phosphate 5-kinase catalyzes the ATP-dependent 5-phosphorylation of 3-phosphomevalonate
-