2.7.1.185: mevalonate 3-kinase
This is an abbreviated version!
For detailed information about mevalonate 3-kinase, go to the full flat file.
Word Map on EC 2.7.1.185
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2.7.1.185
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acidophilum
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thermoplasma
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isopentenyl
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isoprenoids
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pyrophosphate
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decarboxylases
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picrophilus
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archaea
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torridus
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cholesterol
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synthesis
- 2.7.1.185
- acidophilum
-
thermoplasma
-
isopentenyl
-
isoprenoids
- pyrophosphate
- decarboxylases
-
picrophilus
- archaea
- torridus
- cholesterol
- synthesis
Reaction
Synonyms
ATP:(R)-MVA 3-phosphotransferase, M3K, mevalonate 3-kinase, mevalonate-3-kinase, More, PtM3K, PTO1356, Ta1305, TacM3K
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2.7.1.185 mevalonate 3-kinaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 2.7.1.185 - mevalonate 3-kinase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + (R)-2,3-dihydroxyisovalerate
ADP + (R)-2-hydroxy-3-phosphoisovalerate
the Picrophilus torridus mevalonate-3-kinase (M3K) exhibits adenosine triphosphate (ATP) hydrolysis activity when mixed with (R)-2,3-dihydroxyisovalerate (DHIV), indicating phosphorylation activity towards DHIV
-
-
?
ATP + (R)-2,3-dihydroxyisovalerate
ADP + (R)-2-hydroxy-3-phosphoisovalerate
the Picrophilus torridus mevalonate-3-kinase (M3K) exhibits adenosine triphosphate (ATP) hydrolysis activity when mixed with (R)-2,3-dihydroxyisovalerate (DHIV), indicating phosphorylation activity towards DHIV
-
-
?
ATP + (R)-2,3-dihydroxyisovalerate
ADP + (R)-2-hydroxy-3-phosphoisovalerate
the Picrophilus torridus mevalonate-3-kinase (M3K) exhibits adenosine triphosphate (ATP) hydrolysis activity when mixed with (R)-2,3-dihydroxyisovalerate (DHIV), indicating phosphorylation activity towards DHIV
-
-
?
ATP + (R)-2,3-dihydroxyisovalerate
ADP + (R)-2-hydroxy-3-phosphoisovalerate
the Picrophilus torridus mevalonate-3-kinase (M3K) exhibits adenosine triphosphate (ATP) hydrolysis activity when mixed with (R)-2,3-dihydroxyisovalerate (DHIV), indicating phosphorylation activity towards DHIV
-
-
?
ATP + (R)-2,3-dihydroxyisovalerate
ADP + (R)-2-hydroxy-3-phosphoisovalerate
the Picrophilus torridus mevalonate-3-kinase (M3K) exhibits adenosine triphosphate (ATP) hydrolysis activity when mixed with (R)-2,3-dihydroxyisovalerate (DHIV), indicating phosphorylation activity towards DHIV
-
-
?
ATP + (R)-mevalonate
ADP + (R)-3-phosphomevalonate
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-
-
?
ATP + (R)-mevalonate
ADP + (R)-3-phosphomevalonate
key enzyme of the Thermoplasma acidophilum-type mevalonate pathway
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-
?
ATP + (R)-mevalonate
ADP + (R)-3-phosphomevalonate
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-
-
?
ATP + (R)-mevalonate
ADP + (R)-3-phosphomevalonate
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-
-
?
ATP + (R)-mevalonate
ADP + (R)-3-phosphomevalonate
key enzyme of the Thermoplasma acidophilum-type mevalonate pathway
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-
?
ATP + (R)-mevalonate
ADP + (R)-3-phosphomevalonate
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-
-
?
ATP + (R)-mevalonate
ADP + (R)-3-phosphomevalonate
-
-
-
?
ATP + (R)-mevalonate
ADP + (R)-3-phosphomevalonate
-
-
-
?
ATP + (R)-mevalonate
ADP + (R)-3-phosphomevalonate
-
-
-
-
?
ATP + (R)-mevalonate
ADP + (R)-3-phosphomevalonate
-
-
-
-
?
ATP + (R)-mevalonate
ADP + (R)-3-phosphomevalonate
-
-
-
-
?
ATP + (R)-mevalonate
ADP + (R)-3-phosphomevalonate
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-
-
?
ATP + (R)-mevalonate
ADP + (R)-3-phosphomevalonate
mevalonate-3-kinase and mevalonate-3-phosphate-5-kinase act sequentially in a putative alternate mevalonate pathway in Thermoplasma acidophilum
-
-
?
ATP + (R)-mevalonate
ADP + (R)-3-phosphomevalonate
the enzyme is part of a putative alternate mevalonate pathway in Thermoplasma acidophilum
-
-
?
ATP + (R)-mevalonate
ADP + (R)-3-phosphomevalonate
-
-
-
?
ATP + (R)-mevalonate
ADP + (R)-3-phosphomevalonate
-
-
-
?
ATP + (R)-mevalonate
ADP + (R)-3-phosphomevalonate
-
-
-
?
ATP + (R)-mevalonate
ADP + (R)-3-phosphomevalonate
-
-
-
?
ATP + 3-hydroxyisovalerate
ADP + phosphate + isobutene + CO2
the potential of the enzyme in isobutene formation is due to the conversion of 3-hydroxyisovalerate to an unstable 3-phosphate intermediate that undergoes consequent spontaneous decarboxylation to form isobutene
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-
?
ATP + 3-hydroxyisovalerate
ADP + phosphate + isobutene + CO2
the potential of the enzyme in isobutene formation is due to the conversion of 3-hydroxyisovalerate to an unstable 3-phosphate intermediate that undergoes consequent spontaneous decarboxylation to form isobutene
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-
?
additional information
?
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a first reaction strategy is the activaion of (R)-2,3-dihydroxyisovalerate (DHIV) to 3-phospho-DHIV using M3K followed by dehydration by PpManR, StPutD or other sugar acid dehydratases. A second strategy is to use M3K and/or mevalonate decarboxylase (MVD) to convert DHIV to isobutyraldehyde, which can be an alternative pathway for isobutanol biosynthesis
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-
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additional information
?
-
-
a first reaction strategy is the activaion of (R)-2,3-dihydroxyisovalerate (DHIV) to 3-phospho-DHIV using M3K followed by dehydration by PpManR, StPutD or other sugar acid dehydratases. A second strategy is to use M3K and/or mevalonate decarboxylase (MVD) to convert DHIV to isobutyraldehyde, which can be an alternative pathway for isobutanol biosynthesis
-
-
-
additional information
?
-
a first reaction strategy is the activaion of (R)-2,3-dihydroxyisovalerate (DHIV) to 3-phospho-DHIV using M3K followed by dehydration by PpManR, StPutD or other sugar acid dehydratases. A second strategy is to use M3K and/or mevalonate decarboxylase (MVD) to convert DHIV to isobutyraldehyde, which can be an alternative pathway for isobutanol biosynthesis
-
-
-
additional information
?
-
a first reaction strategy is the activaion of (R)-2,3-dihydroxyisovalerate (DHIV) to 3-phospho-DHIV using M3K followed by dehydration by PpManR, StPutD or other sugar acid dehydratases. A second strategy is to use M3K and/or mevalonate decarboxylase (MVD) to convert DHIV to isobutyraldehyde, which can be an alternative pathway for isobutanol biosynthesis
-
-
-
additional information
?
-
a first reaction strategy is the activaion of (R)-2,3-dihydroxyisovalerate (DHIV) to 3-phospho-DHIV using M3K followed by dehydration by PpManR, StPutD or other sugar acid dehydratases. A second strategy is to use M3K and/or mevalonate decarboxylase (MVD) to convert DHIV to isobutyraldehyde, which can be an alternative pathway for isobutanol biosynthesis
-
-
-
additional information
?
-
a first reaction strategy is the activaion of (R)-2,3-dihydroxyisovalerate (DHIV) to 3-phospho-DHIV using M3K followed by dehydration by PpManR, StPutD or other sugar acid dehydratases. A second strategy is to use M3K and/or mevalonate decarboxylase (MVD) to convert DHIV to isobutyraldehyde, which can be an alternative pathway for isobutanol biosynthesis
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additional information
?
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NMR analysis of the product
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additional information
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NMR analysis of the product
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additional information
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NMR analysis of the product
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additional information
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substrate specificity, overview
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additional information
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substrate specificity, overview
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additional information
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substrate specificity, overview
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additional information
?
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substrate specificity, overview
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additional information
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substrate specificity, overview
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