2.7.1.181: polymannosyl GlcNAc-diphospho-ditrans,octacis-undecaprenol kinase
This is an abbreviated version!
For detailed information about polymannosyl GlcNAc-diphospho-ditrans,octacis-undecaprenol kinase, go to the full flat file.
Reaction
Synonyms
WbdD, WbdD kinase, WbdDO9a
ECTree
Advanced search results
Crystallization
Crystallization on EC 2.7.1.181 - polymannosyl GlcNAc-diphospho-ditrans,octacis-undecaprenol kinase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
2.2 A resolution structure reveals a bacterial methyltransferase domain joined to a eukaryotic kinase domain. The kinase domain is again fused to an extended C-terminal coiled-coil domain reminiscent of eukaryotic Myotonic Dystrophy Protein Kinase family kinases. Structures of co-complexes with two known eukaryotic protein kinase inhibitors which are potent inhibitors in vitro, but do not show any in vivo activity
crystallization and modeling by molecular-replacement to obtain high-resolution diffraction, and development of methods to control the hydration status