2.7.1.173: nicotinate riboside kinase
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For detailed information about nicotinate riboside kinase, go to the full flat file.
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Synonyms
More, NaR kinase, nicotinamide riboside kinase, nicotinamide riboside kinase 1, nicotinamide riboside kinase 2, nicotinic acid riboside kinase, nicotinic acid riboside kinase 1, NMRK1, NMRK2, NR kinase, Nrk, NRK1, Nrk2, ribosylnicotinic acid kinase
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General Information on EC 2.7.1.173 - nicotinate riboside kinase
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GENERAL INFORMATION 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
evolution
the enzyme is structurally similar to Rossmann fold metabolite kinases
malfunction
in NRK1-silenced cells, both nicotinamide riboside- and NMN-mediated rescue from FK866-induced NAD+ depletion and cell death are potently and significantly reduced, overview
metabolism
physiological function
additional information
metabolism
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in addition to the seven-component pyridine nucleotide cycle, an eight-component cycle involving nicotinate riboside kinase operates in plants. NaR kinase does not make a significant contribution to salvage for pyridine nucleotide synthesis
metabolism
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nicotinamide riboside elevates NAD+ levels via the nicotinamide riboside kinase pathway and by a pathway initiated by splitting the nucleoside into a nicotinamide base followed by nicotinamide salvage. Yeast nicotinic acid riboside utilization largely depends on uridine hydrolase and nicotinamide riboside kinase, and nicotinic acid riboside bioavailability is increased by ester modification
metabolism
the enzyme is involved in the eukaryotic nicotinamide riboside kinase, Nrk, pathway, which is induced in response to nerve damage and promotes replicative life span in yeast, converts nicotinamide riboside to NAD+ by phosphorylation and adenylylation, overview. Nicotinic acid riboside is utilized in vivo by Urh1, Pnp1, and Preiss-Handler salvage
metabolism
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distinct metabolic routes, starting from various precursors, are known to support NAD+ biosynthesis with tissue/cell-specific efficiencies, probably reflecting differential expression of the corresponding rate-limiting enzymes, i.e. nicotinamide phosphoribosyltransferase, quinolinate phosphoribosyltransferase, nicotinate phosphoribosyltransferase and nicotinamide riboside kinase
metabolism
the enzyme is involved in the NAD+ biosynthesis pathway. In the initial step of the pathway, NRK activity catalyses the phosphorylation of nicotinamide riboside (NR) to nicotinamide mononucleotide (NMN), see for EC 2.7.1.22. Importance of different salvage pathways involved in metabolising the vitamin B3 class of NAD+ precursor molecules, with a particular focus on the nicotinamide riboside kinase pathway at both a tissue-specific and systemic level, regulation of the NRK enzymes, overview. Alternatively, NRK activity can phosphorylate nicotinic acid riboside (NaR) to nicotinic acid mononucleotide (NaMN)
metabolism
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nicotinamide riboside elevates NAD+ levels via the nicotinamide riboside kinase pathway and by a pathway initiated by splitting the nucleoside into a nicotinamide base followed by nicotinamide salvage. Yeast nicotinic acid riboside utilization largely depends on uridine hydrolase and nicotinamide riboside kinase, and nicotinic acid riboside bioavailability is increased by ester modification
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physiological function
nicotinamide riboside kinase has an important role in the biosynthesis of NAD+ as well as the activation of tiazofurin and other nicotinamide riboside analogues for anticancer therapy
physiological function
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nicotinamide riboside kinase increases the NAD+ levels via convertion of the substrate nicotinamide riboside and thereby extending replicative lifespan and increases Sir2-dependent gene silencing
physiological function
NRK2 appears to play a redundant role in NAD+ biosynthesis along with NRK1, at least in unchallenged models, its highly regulated expression particularly in times of stress suggest it may have role beyond NAD+ metabolism
physiological function
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nicotinamide riboside kinase increases the NAD+ levels via convertion of the substrate nicotinamide riboside and thereby extending replicative lifespan and increases Sir2-dependent gene silencing
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additional information
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comparison to the Nrk-independent utilization pathway of nicotinamide riboside in yeast, overview
additional information
proposed NRK expression in disease and potential therapeutic interventions
additional information
proposed NRK expression in disease and potential therapeutic interventions
additional information
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comparison to the Nrk-independent utilization pathway of nicotinamide riboside in yeast, overview
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