2.7.1.172: protein-ribulosamine 3-kinase
This is an abbreviated version!
For detailed information about protein-ribulosamine 3-kinase, go to the full flat file.
Word Map on EC 2.7.1.172
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2.7.1.172
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deglycation
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erythrocytes
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ribose
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amadori
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5-phosphate
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fructoselysine
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nonenzymatic
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protein-bound
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maillard
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erythrose
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haemoglobin
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decomposing
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tata-less
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transglycation
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sphingosine
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protein-repair
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caat-less
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ketoamine
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endproducts
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non-physiological
- 2.7.1.172
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deglycation
- erythrocytes
- ribose
-
amadori
- 5-phosphate
- fructoselysine
-
nonenzymatic
-
protein-bound
-
maillard
- erythrose
- haemoglobin
-
decomposing
-
tata-less
-
transglycation
- sphingosine
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protein-repair
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caat-less
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ketoamine
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endproducts
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non-physiological
Reaction
Synonyms
FN3K-related protein, FN3K-RP, Fn3KRP, fructosamine 3-kinase-related protein, fructosamine-3-kinase-related protein, fructosamine-3-kinase–related protein, ketosamine 3-kinase 2, ribulosamine/erythrulosamine 3-kinase
ECTree
2.7.1.172 protein-ribulosamine 3-kinaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 2.7.1.172 - protein-ribulosamine 3-kinase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + (R)-1-(5-(3-amino-4-hydroxy-3-methylbutyl)-1-methyl-1H-pyrrol-2-yl)-4-(p-tolyl)butan-1-one
ADP + (2R)-2-amino-2-methyl-4-(1-methyl)-5-[4-(4-methylphenyl)butanoyl]-1H-pyrrol-2-yl)butyl dihydrogen phosphate
CS-0777
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-
ir
ATP + 1-deoxy-1-morpholin-4-yl-D-psicose
ADP + 1-deoxy-1-morpholin-4-yl-3-O-phosphono-D-psicose
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-
-
?
ATP + 1-deoxy-1-morpholin-4-yl-D-ribulose
ADP + 1-deoxy-1-morpholin-4-yl-3-O-phosphono-D-ribulose
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-
-
?
ATP + N6-D-psicosyl-L-lysine
ADP + N6-(O3-phosphono-D-psicosyl)-L-lysine
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-
-
?
ATP + [lysozyme]-N6-D-erythrulosyl-L-lysine
ADP + [lysozyme]-N6-(O3-phosphono-D-erythrulosyl)-L-lysine
ATP + [lysozyme]-N6-D-psicosyl-L-lysine
ADP + [lysozyme]-N6-(O3-phosphono-D-psicosyl)-L-lysine
in contrast with free psicose-lysine, not all psicosamine residues in the glycated lysozyme substrate would be expected to be accessible to the Fn3KRP active site. In addition, local charge effects may influence the relative affinity for psicosamine residues at different sites in the lysozyme substrate
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-
?
ATP + [lysozyme]-N6-D-ribulosyl-L-lysine
ADP + [lysozyme]-N6-(O3-phosphono-D-ribulosyl)-L-lysine
ATP + [protein]-N6-D-psicosyl-L-lysine
ADP + [protein]-N6-(O3-phosphono-D-psicosyl)-L-lysine
ATP + [protein]-N6-D-ribulosyl-L-lysine
ADP + [protein]-N6-(3-O-phospho-D-ribulosyl)-L-lysine
ATP + N6-D-erythrulosyl-L-lysine
ADP + N6-(O3-phosphono-D-erythrulosyl)-L-lysine
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-
-
-
?
ATP + N6-D-erythrulosyl-L-lysine
ADP + N6-(O3-phosphono-D-erythrulosyl)-L-lysine
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-
-
-
?
ATP + N6-D-ribulosyl-L-lysine
ADP + N6-(O3-phosphono-D-ribulosyl)-L-lysine
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-
-
-
?
ATP + N6-D-ribulosyl-L-lysine
ADP + N6-(O3-phosphono-D-ribulosyl)-L-lysine
-
-
-
-
?
ATP + [lysozyme]-N6-D-erythrulosyl-L-lysine
ADP + [lysozyme]-N6-(O3-phosphono-D-erythrulosyl)-L-lysine
-
-
-
-
?
ATP + [lysozyme]-N6-D-erythrulosyl-L-lysine
ADP + [lysozyme]-N6-(O3-phosphono-D-erythrulosyl)-L-lysine
-
-
-
-
?
ATP + [lysozyme]-N6-D-ribulosyl-L-lysine
ADP + [lysozyme]-N6-(O3-phosphono-D-ribulosyl)-L-lysine
-
-
-
-
?
ATP + [lysozyme]-N6-D-ribulosyl-L-lysine
ADP + [lysozyme]-N6-(O3-phosphono-D-ribulosyl)-L-lysine
-
-
-
-
?
ATP + [protein]-N6-D-psicosyl-L-lysine
ADP + [protein]-N6-(O3-phosphono-D-psicosyl)-L-lysine
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-
-
?
ATP + [protein]-N6-D-psicosyl-L-lysine
ADP + [protein]-N6-(O3-phosphono-D-psicosyl)-L-lysine
ketosamine-3-kinase 2 plays a role in freeing proteins from ribulosamines or psicosamines, which might arise in a several step process, from the reaction of amines with glucose and/or glycolytic intermediates. This role is shared by fructosamine-3-kinase (ketosamine-3-kinase 1), which has, in addition, the unique capacity to phosphorylate fructosamines
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-
?
ATP + [protein]-N6-D-ribulosyl-L-lysine
ADP + [protein]-N6-(3-O-phospho-D-ribulosyl)-L-lysine
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-
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?
ATP + [protein]-N6-D-ribulosyl-L-lysine
ADP + [protein]-N6-(3-O-phospho-D-ribulosyl)-L-lysine
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-
-
-
?
ATP + [protein]-N6-D-ribulosyl-L-lysine
ADP + [protein]-N6-(3-O-phospho-D-ribulosyl)-L-lysine
ketosamine-3-kinase 2 plays a role in freeing proteins from ribulosamines or psicosamines, which might arise in a several step process, from the reaction of amines with glucose and/or glycolytic intermediates. This role is shared by fructosamine-3-kinase (ketosamine-3-kinase 1), which has, in addition, the unique capacity to phosphorylate fructosamines
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-
?
additional information
?
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the enzyme does not act on fructosy-L-lysine or lysozyme glycated with glucose or allose
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-
?
additional information
?
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-
acts best on free lysine and cadaverine derivatives, but not on ribulosamines bound to the alpha amino group of amino acids. Phosphorylates protein-bound ribulosamines or erythrulosamines, but not protein-bound fructosamines
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-
?
additional information
?
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FN3K-RP can act inside erythrocytes as a deglycating enzyme by converting ketoamines into unstable phosphate esters. Potential physiological substrates are psicosamines, which appear to be formed slowly from fructosamines
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-
?
additional information
?
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FN3K-RP can act inside erythrocytes as a deglycating enzyme by converting ketoamines into unstable phosphate esters. Potential physiological substrates are psicosamines, which appear to be formed slowly from fructosamines
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-
?
additional information
?
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FN3K-RP does not phosphorylate fructoselysine, 1-deoxy-1-morpholin-4-yl-D-fructose, or lysozyme glycated with glucose
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-
?
additional information
?
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FN3K-RP does not phosphorylate fructoselysine, 1-deoxy-1-morpholin-4-yl-D-fructose, or lysozyme glycated with glucose
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-
?
additional information
?
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FN3K-RP progressively phosphorylates haemoglobin from erythrocytes that had been incubated with allose or ribose
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-
?
additional information
?
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FN3K-RP progressively phosphorylates haemoglobin from erythrocytes that had been incubated with allose or ribose
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-
?
additional information
?
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acts best on free lysine and cadaverine derivatives, but not on ribulosamines bound to the alpha amino group of amino acids. Phosphorylates protein-bound ribulosamines or erythrulosamines, but not protein-bound fructosamines
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-
?
additional information
?
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-
ribuloseglycine, ribulosevaline and ribuloseleucine are phosphorylated at 5–10% of the rate observed with 1 mM ribuloselysine, whereas no detectable phosphorylation (<1% of the rate observed with ribuloselysine) is observed with fructoselysine, deoxymorpholinofructose, D-ribulose and D-erythrulose. The purified enzyme does not phosphorylate protein-bound fructosamines, psicosamines or ribulosamine 5-phosphates, but does act on protein-bound ribulosamines and erythrulosamines
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-
?
additional information
?
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acts best on free lysine and cadaverine derivatives, but not on ribulosamines bound to the alpha amino group of amino acids. Phosphorylates protein-bound ribulosamines or erythrulosamines, but not protein-bound fructosamines
-
-
?
additional information
?
-
-
acts best on free lysine and cadaverine derivatives, but not on ribulosamines bound to the alpha amino group of amino acids. Phosphorylates protein-bound ribulosamines or erythrulosamines, but not protein-bound fructosamines
-
-
?
