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2.7.1.172: protein-ribulosamine 3-kinase

This is an abbreviated version!
For detailed information about protein-ribulosamine 3-kinase, go to the full flat file.

Word Map on EC 2.7.1.172

Reaction

ATP
+
[protein]-N6-D-ribulosyl-L-lysine
=
ADP
 +
[protein]-N6-(3-O-phospho-D-ribulosyl)-L-lysine

Synonyms

FN3K-related protein, FN3K-RP, Fn3KRP, fructosamine 3-kinase-related protein, fructosamine-3-kinase-related protein, fructosamine-3-kinase–related protein, ketosamine 3-kinase 2, ribulosamine/erythrulosamine 3-kinase

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.172 protein-ribulosamine 3-kinase

Inhibitors

Inhibitors on EC 2.7.1.172 - protein-ribulosamine 3-kinase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1-deoxy-1-morpholin-4-yl-D-psicose
-
1-deoxy-1-morpholin-4-yl-D-ribulose
-
1-deoxy-1-morpholino-D-ribulose
-
0.25 mM, 50% inhibition
1-deoxy-1-morpholinopsicose
competitive inhibitor
5'-p-[(fluorosulfonyl)benzoyl]adenosine
incubation of 0.7 mg/ml Fn3KRP with 0.5 mM inhibitor results in significant activity loss compared with controls. The inhibitor inactivates Fn3KRP by modification of residues at the nucleotide-binding site
N6-D-psicosyl-L-lysine
-
ribuloselysine
-
0.1 mM, 50% inhibition
additional information
-
neither fructosamines (fructoselysine and deoxymorpholinofructose) nor psicoselysine affect the enzymatic activity at concentrations up to 1 mM. No inhibition is observed with ribulosamines bound to the alpha-amino groups of glycine, valine or leucine, or with D-ribulose or D-erythrulose (all tested at 1 mM)
-