2.7.1.171: protein-fructosamine 3-kinase
This is an abbreviated version!
For detailed information about protein-fructosamine 3-kinase, go to the full flat file.
Word Map on EC 2.7.1.171
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2.7.1.171
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deglycation
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erythrocyte
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fructoselysine
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protein-bound
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fn3krp
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non-enzymatic
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fn3k-related
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amadori
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endproducts
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dmf
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maillard
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protein-repairing
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glycemia
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ketoamine
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3-kinase-related
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3-deoxyglucosone
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medicine
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analysis
- 2.7.1.171
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deglycation
- erythrocyte
- fructoselysine
-
protein-bound
- fn3krp
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non-enzymatic
-
fn3k-related
-
amadori
-
endproducts
- dmf
-
maillard
-
protein-repairing
-
glycemia
-
ketoamine
-
3-kinase-related
- 3-deoxyglucosone
- medicine
- analysis
Reaction
Synonyms
AtFN3K, FL3P, FN3K, fructosamine 3 kinase, fructosamine 3-kinase, fructosamine-3-kinase, fructose-3-kinase, HsFN3K, ketosamine 3-kinase 1
ECTree
2.7.1.171 protein-fructosamine 3-kinaseAdvanced search results
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results (Engineering
Engineering on EC 2.7.1.171 - protein-fructosamine 3-kinase
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PROTEIN VARIANTS 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
C236A
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site-directed mutagenesis, similar to the wild-type enzyme, both dimeric and monomeric forms are detected
C236S
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site-directed mutagenesis, similar to the wild-type enzyme, both dimeric and monomeric forms are detected
C32A
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site-directed mutagenesis, similar to the wild-type enzyme, both dimeric and monomeric forms are detected
C32A/C236A/C196A
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site-directed mutagenesis, similar to the wild-type enzyme, both dimeric and monomeric forms are detected
C32S
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site-directed mutagenesis, similar to the wild-type enzyme, both dimeric and monomeric forms are detected
additional information
additional information
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diabetic subjects with the CC variant of SNP rs1056534 (G900C), which is associated with a higher FN3K activity, have lower HbA1c levels compared with other genotypes
additional information
the G900C (rs1056534) single nucleotide polymorphism of the FN3K gene is associated with the enzyme activity, with the level of HbA and the onset of the disease, but not with either of the diabetic microvascular complications
additional information
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the G900C (rs1056534) single nucleotide polymorphism of the FN3K gene is associated with the enzyme activity, with the level of HbA and the onset of the disease, but not with either of the diabetic microvascular complications
additional information
analysis of the FN3K gene on a Caucasian cohort of diabetic patients, molecular characterization of the FN3K gene by analyzing its promoter and of polymorphisms, c-385A/G (rs3859206) and the c-232A/T (rs2256339), associated with FN3K enzymatic activity in erythrocytes, as well as two variants c-421C/T and c-429delATCGGAG
additional information
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analysis of the FN3K gene on a Caucasian cohort of diabetic patients, molecular characterization of the FN3K gene by analyzing its promoter and of polymorphisms, c-385A/G (rs3859206) and the c-232A/T (rs2256339), associated with FN3K enzymatic activity in erythrocytes, as well as two variants c-421C/T and c-429delATCGGAG
additional information
while GG and CG genotypes of rs1056534 with mutated G allele are associated with significant decrease of sRAGE, in rs3848403 polymorphism TT genotype with mutated T allele is related with significant sRAGE increase
additional information
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while GG and CG genotypes of rs1056534 with mutated G allele are associated with significant decrease of sRAGE, in rs3848403 polymorphism TT genotype with mutated T allele is related with significant sRAGE increase
additional information
allelic variants of FN3K polymorphisms revealed 13 distinct genotypic variants in a cohort of patients with type 2 diabetes mellitus (T2DM), detection of three polymorphisms associated with the enzymatic activity (rs3859206 and rs2256339 in the promoter region and rs1056534 in exon 6). The FN3K genotype presenting GG at position -385, TT at position -232, and CC at c.900 A, is associated with less severe microangiopathic and macroangiopathic complications as a whole, compared to all other genotypes
additional information
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allelic variants of FN3K polymorphisms revealed 13 distinct genotypic variants in a cohort of patients with type 2 diabetes mellitus (T2DM), detection of three polymorphisms associated with the enzymatic activity (rs3859206 and rs2256339 in the promoter region and rs1056534 in exon 6). The FN3K genotype presenting GG at position -385, TT at position -232, and CC at c.900 A, is associated with less severe microangiopathic and macroangiopathic complications as a whole, compared to all other genotypes
additional information
knockdown of FN3K with two different shRNAs in HepG2 cells and in H3255 cells. The mutant cells have higher levels of NRF2, and both FACS assay and immunoblot show reduction of NRF2 protein upon knockdown of either FN3K or NRF2. FN3K deficiency leads to increased proteasomal and MG132-sensitive degradation of the glycated NRF2 protein
