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2.7.1.169: pantoate kinase

This is an abbreviated version!
For detailed information about pantoate kinase, go to the full flat file.

Word Map on EC 2.7.1.169

Reaction

ATP
+
(R)-pantoate
=
ADP
 +
(R)-4-phosphopantoate

Synonyms

COG1829, Mhun_0831, PoK, TK2141, TK2141 protein, TkPoK

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.169 pantoate kinase

Engineering

Engineering on EC 2.7.1.169 - pantoate kinase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D143
residue is the base responsible for proton abstraction from the pantoate hydroxy group
E134A
residue is involved in binding with Mg2+
H131A
residue is involved in pantoate recognition. 77% of wild-type activity in presence of 6 mM pantoate and 4 mM ATP
R155A
residue is involved in pantoate recognition and plays an important role in catalysis
S104A
residue is involved in binding with phosphate
S28A
residue is involved in pantoate recognition. 3.7% of wild-type activity in presence of 6 mM pantoate and 4 mM ATP
T186A
residue is involved in pantoate recognition and plays an important role in catalysis. Thr186 is involved in dimer assambly