2.7.1.167: D-glycero-beta-D-manno-heptose-7-phosphate kinase
This is an abbreviated version!
For detailed information about D-glycero-beta-D-manno-heptose-7-phosphate kinase, go to the full flat file.
Reaction
Synonyms
bifunctional D-beta-D-heptose-7-phosphate kinase/D-beta-dheptose-1-phosphate adenylyltransferase, D-beta-D-heptose 7-phosphate kinase/D-beta-D-heptose 1-phosphate adenylyltransferase, D-beta-D-heptose 7-phosphotransferase, D-beta-D-heptose-7-phosphate kinase, glycero-manno-heptose 7-phosphate kinase, heptose 7-phosphate kinase, HldE, HldE1 heptokinase
ECTree
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Substrates Products
Substrates Products on EC 2.7.1.167 - D-glycero-beta-D-manno-heptose-7-phosphate kinase
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REACTION DIAGRAM
7-O-phosphono-6-deoxy-glycero-D-manno-heptopyranosyl phosphate + ATP
? + ADP
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low activity
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-
?
7-phosphate-D-glycero-beta-D-manno-heptose + ATP
D-glycero-D-manno-beta-heptose 1,7-bisphosphate + ADP
-
-
-
-
?
D-glycero-beta-D-manno-heptose 7-phosphate + ATP
D-glycero-beta-D-manno-heptose 1,7-bisphosphate + ADP
D-glycero-D-manno-heptose 7-phosphate + ATP
D-glycero-beta-D-manno-heptose 1,7-bisphosphate + ADP
D-glycero-D-manno-heptose 7-phosphate + ATP
D-glycero-beta-D-mannoheptose 1,7-bisphosphate + ADP
D-glycero-beta-D-manno-heptose 1,7-bisphosphate + ADP
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-
-
?
D-glycero-beta-D-manno-heptose 7-phosphate + ATP
D-glycero-beta-D-manno-heptose 1,7-bisphosphate + ADP
-
-
-
?
D-glycero-beta-D-manno-heptose 1,7-bisphosphate + ADP
the enzyme selectively produces D-glycero-beta-D-mannoheptose 1,7-bisphosphate
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-
?
D-glycero-D-manno-heptose 7-phosphate + ATP
D-glycero-beta-D-manno-heptose 1,7-bisphosphate + ADP
-
-
-
?
D-glycero-D-manno-heptose 7-phosphate + ATP
D-glycero-beta-D-manno-heptose 1,7-bisphosphate + ADP
-
-
-
-
?
D-glycero-D-manno-heptose 7-phosphate + ATP
D-glycero-beta-D-manno-heptose 1,7-bisphosphate + ADP
synthesis of ADP-D-beta-D-heptose in Escherichia coli requires three proteins, GmhA (sedoheptulose 7-phosphate isomerase), HldE (bifunctional D-beta-D-heptose 7-phosphate kinase/D-beta-D-heptose 1-phosphate adenylyltransferase), and GmhB (D,D-heptose 1,7-bisphosphate phosphatase)
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-
?
D-glycero-D-manno-heptose 7-phosphate + ATP
D-glycero-beta-D-manno-heptose 1,7-bisphosphate + ADP
-
exclusively forming the beta-anomer, namely, D-glycero-beta-D-manno-heptose-1,7-bisphosphate
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-
?
D-glycero-D-manno-heptose 7-phosphate + ATP
D-glycero-beta-D-manno-heptose 1,7-bisphosphate + ADP
-
anomeric phosphorylation by the kinase activity of HldE exclusively forming the beta-anomer, namely, D-glycero-beta-D-manno-heptose-1,7-bisphosphate
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-
?
D-glycero-beta-D-mannoheptose 1,7-bisphosphate + ADP
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-
-
-
?
D-glycero-D-manno-heptose 7-phosphate + ATP
D-glycero-beta-D-mannoheptose 1,7-bisphosphate + ADP
-
bifunctional D-beta-D-heptose-7-phosphate kinase/D-beta-D-heptose-1-phosphate adenylyltransferase. Based on genomic sequence comparisons, bifunctional proteins are predicted to be present in several Gram-negative microorganisms, including Agrobacterium tumefaciens, Buchnera sp., Caulobacter crescentus, Salmonella typhimurium, Salmonella typhi, Vibrio cholerae, Yersinia pestis, Haemophilus influenzae, Helicobacter pylori and Pseudomonas aeruginosa. In contrast, individual genes encoding domains I and II independently are found in Ralstonia eutropha, Neisseria meningitidis and Neisseria gonorrhoeae. In these cases, it is proposed to use the nomenclature hldA and hldC to indicate the individual kinase- and adenylyltransferase-encoding genes, respectively
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?
?
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rfaE encodes a bifunctional protein. It is proposed that domain I is involved in the synthesis of D-glycero-D-manno-heptose 1-phosphate, whereas domain II catalyzes the ADP transfer to form ADP-D-glycero-D-manno-heptose
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-
?
additional information
?
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HldE has highly restricted substrate specificity towards structurally modified heptose-7-phosphate analogues, substrate specificity of enzyme HldE, overview. No activity with D,L-glycero-D-manno-heptose, mannose 6-phosphate, 7-O-phosphono-L-glycero-D-manno-heptopyranosyl phosphate, and 7-O-sulfo-D-glycero-D-manno-heptopyranoside
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-
?
additional information
?
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involved in the formation of ADP-L-glycero-D-manno-heptose
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-
?