2.7.1.167: D-glycero-beta-D-manno-heptose-7-phosphate kinase

This is an abbreviated version!
For detailed information about D-glycero-beta-D-manno-heptose-7-phosphate kinase, go to the full flat file.

Reaction

Synonyms

bifunctional D-beta-D-heptose-7-phosphate kinase/D-beta-dheptose-1-phosphate adenylyltransferase, D-beta-D-heptose 7-phosphate kinase/D-beta-D-heptose 1-phosphate adenylyltransferase, D-beta-D-heptose 7-phosphotransferase, D-beta-D-heptose-7-phosphate kinase, glycero-manno-heptose 7-phosphate kinase, heptose 7-phosphate kinase, HldE, HldE1 heptokinase

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.1 Phosphotransferases with an alcohol group as acceptor

                2.7.1.167 D-glycero-beta-D-manno-heptose-7-phosphate kinase

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Results	in table
9003	AA Sequence
3	Cloned(Commentary)
1	Cofactor
1	Crystallization (Commentary)
2	IC50 Value
2	Inhibitors
1	Metals/Ions
3	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
10	Organism
3	Pathway
8	PDB ID
1	pH Optimum
5	Protein Variants
1	Purification (Commentary)
1	Reaction
10	Reference
15	Substrates and Products (Substrate)
4	Subunits
8	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Natural Substrates Products

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Natural Substrates Products on EC 2.7.1.167 - D-glycero-beta-D-manno-heptose-7-phosphate kinase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

D-glycero-D-manno-heptose 7-phosphate + ATP

D-glycero-beta-D-manno-heptose 1,7-bisphosphate + ADP

2 entries

D-glycero-D-manno-heptose 7-phosphate + ATP

D-glycero-beta-D-mannoheptose 1,7-bisphosphate + ADP

Escherichia coli

-

-

700026

-

-

?

additional information

?

-

2 entries

D-glycero-D-manno-heptose 7-phosphate + ATP

D-glycero-beta-D-manno-heptose 1,7-bisphosphate + ADP

Escherichia coli

P76658

synthesis of ADP-D-beta-D-heptose in Escherichia coli requires three proteins, GmhA (sedoheptulose 7-phosphate isomerase), HldE (bifunctional D-beta-D-heptose 7-phosphate kinase/D-beta-D-heptose 1-phosphate adenylyltransferase), and GmhB (D,D-heptose 1,7-bisphosphate phosphatase)

698565

-

-

?

D-glycero-D-manno-heptose 7-phosphate + ATP

D-glycero-beta-D-manno-heptose 1,7-bisphosphate + ADP

Escherichia coli

-

exclusively forming the beta-anomer, namely, D-glycero-beta-D-manno-heptose-1,7-bisphosphate

737835

-

-

?

additional information

?

-

Escherichia coli

P76658

rfaE encodes a bifunctional protein. It is proposed that domain I is involved in the synthesis of D-glycero-D-manno-heptose 1-phosphate, whereas domain II catalyzes the ADP transfer to form ADP-D-glycero-D-manno-heptose

698557

-

-

?

additional information

?

-

Salmonella enterica subsp. enterica serovar Typhimurium

Q7CPR9

involved in the formation of ADP-L-glycero-D-manno-heptose

698130

-

-

?