2.7.1.159: inositol-1,3,4-trisphosphate 5/6-kinase

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For detailed information about inositol-1,3,4-trisphosphate 5/6-kinase, go to the full flat file.

Reaction

Synonyms

1,3,4-trisphosphate 5/6-kinase, 5/6 kinase, 5/6-kinase, At2G43980, AtITPK1, AtITPK2, AtITPK3, AtITPK4, GmItpk2, inositol 1,3,4 tris phosphate 5/6 kinase-2, inositol 1,3,4 trisphosphate kinase-2, inositol 1,3,4-triphosphate 5/6 kinase, inositol 1,3,4-triphosphate 5/6-kinase, inositol 1,3,4-trisphosphate 5/6 kinase-2, inositol 1,3,4-trisphosphate 5/6-kinase, inositol 1,3,4-trisphosphate 5/6-kinase 1, inositol 1,3,4-trisphosphate 5/6-kinase 4, inositol 1,3,4-trisphosphate 5/6-kinase6, inositol 1,4,5 trisphosphate 3/6 kinase, inositol-1,3,4-trisphosphate kinase, Ins(1,3,4)P3 5/6-kinase, IP56K, Ipk2, ITPK, Itpk-1, ITPK1, ITPK2, ITPK3, More, Os09g0518700, OsITL1, OsITPK6

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.1 Phosphotransferases with an alcohol group as acceptor

                2.7.1.159 inositol-1,3,4-trisphosphate 5/6-kinase

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Results	in table
4	Activating Compound
1415	AA Sequence
1	Application
1	CAS Registry Number
20	Cloned(Commentary)
21	Cofactor
2	Crystallization (Commentary)
5	Disease/ Diagnostics
7	Expression
21	General Information
1	General Stability
7	Inhibitors
3	Ki Value [mM]
4	KM Value [mM]
7	Localization
20	Metals/Ions
7	Molecular Weight [Da]
51	Natural Substrates/ Products (Substrates)
32	Organism
7	Pathway
11	PDB ID
9	pH Optimum
3	pI Value
2	Posttranslational Modification
10	Protein Variants
14	Purification (Commentary)
6	Reaction
5	Reaction Type
29	Reference
46	Source Tissue
8	Specific Activity [micromol/min/mg]
94	Substrates and Products (Substrate)
8	Subunits
53	Synonyms
1	Systematic Name
10	Temperature Optimum [°C]
2	Turnover Number [1/s]

Posttranslational Modification

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Posttranslational Modification on EC 2.7.1.159 - inositol-1,3,4-trisphosphate 5/6-kinase

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POSTTRANSLATIONAL MODIFICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

phosphoprotein

Arabidopsis thaliana

Q9SUG3

the enzyme performs autophosphorylation

663162

additional information

Homo sapiens

-

isoform ITPK1 can be acetylated by the acetyltransferases CREB-binding protein, CBP, and p300 both in vivo and in vitro and can be deacetylated by mammalian silent information regulator 2, SIRT1. Acetylation of ITPK1 decreases its enzyme activity and protein stability, and inhibits the synthesis of higher phosphorylated forms of inositol polyphosphates in the inositol signaling pathway. The acetylation sites are lysine residues 340, 383, and 410, which are all located on the surface of the protein

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