2.7.1.156: adenosylcobinamide kinase
This is an abbreviated version!
For detailed information about adenosylcobinamide kinase, go to the full flat file.
Word Map on EC 2.7.1.156
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2.7.1.156
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typhimurium
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guanylylation
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nucleoside
-
cobalamin
-
nonorthologous
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enterica
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nucleotidyltransferase
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adenosylcobalamin
-
cobamide
- 2.7.1.156
- typhimurium
-
guanylylation
- nucleoside
- cobalamin
-
nonorthologous
- enterica
-
nucleotidyltransferase
- adenosylcobalamin
- cobamide
Reaction
Synonyms
adenosylcobinamide kinase, adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase, AdoCbi kinase/AdoCbi-phosphate guanylyltransferase, ATP/GTP:AdoCbi kinase, bifunctional CobU enzyme, CobP, CobU, CobU AdoCbi kinase, CobU protein, GTP:adenosylcobinamide-phosphate guanylyltransferase, GTP:AdoCbi-P kinase, GTP:AdoCbi-phosphate guanylyltransferase, NTP:adenosylcobinamide kinase, NTP:AdoCbi kinase
ECTree
2.7.1.156 adenosylcobinamide kinaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 2.7.1.156 - adenosylcobinamide kinase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
adenosylcobinamide + ATP
adenosylcobinamide phosphate + ADP
-
-
-
-
ir
adenosylcobinamide + GTP
adenosylcobinamide phosphate + GDP
-
-
-
-
ir
adenosylcobinamide phosphate + GTP
adenosylcobinamide-GDP + diphosphate
-
-
-
-
?
adenosylcobinamide phosphate + GTP
adenosylcobinamide-GDP + diphosphate
-
-
-
-
ir
adenosylcobinamide phosphate + GTP
adenosylcobinamide-GDP + diphosphate
-
adenosylcobinamide-phosphate guanylyltransferase activity
-
-
ir
ATP + adenosylcobinamide
adenosylcobinamide phosphate + ADP
-
cobalamin biosynthesis, involved in de novo synthesis of vitamin B12
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?
ATP + adenosylcobinamide
adenosylcobinamide phosphate + ADP
-
cobalamin biosynthesis, involved in de novo synthesis of vitamin B12
-
?
ATP + adenosylcobinamide
adenosylcobinamide phosphate + ADP
-
cobalamin biosynthesis, involved in de novo synthesis of vitamin B12
-
?
ATP + adenosylcobinamide
adenosylcobinamide phosphate + ADP
-
cobalamin biosynthesis, involved in de novo synthesis of vitamin B12
-
?
ATP + adenosylcobinamide
adenosylcobinamide phosphate + ADP
-
cobalamin biosynthesis, involved in de novo synthesis of vitamin B12, uses GTP to guanylate itself, then transfers this GMP group to AdoCbi-P to yield AdoCbi-GDP, the final product of the reaction, CobU enzyme in vivo is always guanylated, guanylation is necessary for both kinase and guanyltransferase activity
-
?
ATP + adenosylcobinamide
adenosylcobinamide phosphate + ADP
-
-
-
?
ATP + adenosylcobinamide
adenosylcobinamide phosphate + ADP
-
-
-
?
ATP + adenosylcobinamide
adenosylcobinamide phosphate + ADP
-
-
-
?
ATP + adenosylcobinamide
adenosylcobinamide phosphate + ADP
-
assembly of the nucleotide loop of cobalamin
-
?
ATP + adenosylcobinamide
adenosylcobinamide phosphate + ADP
-
cobalamin biosynthesis, involved in de novo synthesis of vitamin B12
-
?
ATP + adenosylcobinamide
adenosylcobinamide phosphate + ADP
-
cobalamin biosynthesis, involved in de novo synthesis of vitamin B12
-
?
ATP + adenosylcobinamide
adenosylcobinamide phosphate + ADP
-
late steps of cobalamin biosynthesis, involved in de novo synthesis of vitamin B12, nucleotide loop assembly, enzyme functions only if Salmonella typhimurium is assimilating cobinamide from its environment, CobU becomes less active during the kinase reaction due to the formation of a covalent CobU-AMP complex that holds CobU in an altered conformation
-
?
ATP + adenosylcobinamide
adenosylcobinamide phosphate + ADP
-
adenosylcobinamide kinase activity
-
-
ir
GTP + adenosylcobinamide
adenosylcobinamide phosphate + GDP
-
-
-
?
GTP + adenosylcobinamide
adenosylcobinamide phosphate + GDP
-
-
-
?
GTP + adenosylcobinamide
adenosylcobinamide phosphate + GDP
-
-
-
?
GTP + adenosylcobinamide
adenosylcobinamide phosphate + GDP
-
-
-
?
GTP + adenosylcobinamide
adenosylcobinamide phosphate + GDP
-
-
-
?
GTP + adenosylcobinamide
adenosylcobinamide phosphate + GDP
-
-
-
?
GTP + adenosylcobinamide
adenosylcobinamide phosphate + GDP
-
-
-
?
GTP + adenosylcobinamide
adenosylcobinamide phosphate + GDP
-
-
-
?
GTP + adenosylcobinamide
adenosylcobinamide phosphate + GDP
-
assembly of the nucleotide loop of cobalamin
-
?
additional information
?
-
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the enzyme is involved in adenosylcobalamin de novo biosynthesis, overview
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-
?
additional information
?
-
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CobU enzyme is required for synthesis of both coenzyme B12 (alpha ligand: 5,6-dimethylbenzimidazole) and pseudo-coenzyme B12 (alpha ligand: adenine).
-
-
?
additional information
?
-
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CobU enzyme of the nucleotide loop assembly pathway is a bifunctional enzyme with adenosylcobinamide and adenosylcobinamide-phosphate guanylyltransferase activity, important for de novo synthesis and for cobinamide salvaging
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-
?
