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2.7.1.153: phosphatidylinositol-4,5-bisphosphate 3-kinase

This is an abbreviated version!
For detailed information about phosphatidylinositol-4,5-bisphosphate 3-kinase, go to the full flat file.

Word Map on EC 2.7.1.153

Reaction

ATP
+
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
=
ADP
 +
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate

Synonyms

class I phosphoinositide 3-kinase, class I PI3K, class IA phosphatidylinositol 3-kinase, class IA phosphatidylinositol-4,5-bisphosphate 3-kinase, CXCR2/phosphatidylinositol 3-kinase gamma, kinase (phosphorylating), phosphatidylinositol 4,5-diphosphate 3-, More, p101-PI3K, p110alpha, p110beta, p110delta, p110delta PI 3-kinase, p110gamma/p101, P120-PI3K, phosphatidyl-inositol-3-kinase, phosphatidylinositol (4,5)-bisphosphate 3-hydroxykinase, phosphatidylinositol 3'-kinase, phosphatidylinositol 3-hydroxyl kinase, phosphatidylinositol 3-kinase alpha, phosphatidylinositol 3-kinase gamma, phosphatidylinositol-4,5-bisphosphate 3-kinase, phosphoinositide 3-kinase, phosphoinositide 3-kinase p110delta, phosphoinositol 3-kinase, PI 3-K, PI 3-kinase, PI-3K, PI3-K, PI3-kinase, PI3K, PI3K p110delta, PI3Kalpha, PI3Kbeta, PI3Kdelta, PI3Kgamma, PI3Kp110delta, PIK3, PIK3CA, Pik3r1, PtdIns(4,5)P2 3-OH kinase, PtdIns-3-kinase p101, PtdIns-3-kinase p110, PtdInsP 3-OH-kinase, type I phosphoinositide 3-kinase

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.153 phosphatidylinositol-4,5-bisphosphate 3-kinase

Reference

topprint

Reference on EC 2.7.1.153 - phosphatidylinositol-4,5-bisphosphate 3-kinase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Vanhaesebroeck, B.; Leevers, S.J.; Ahmadi, K.; Timms, J.; Katso, R.; Driscoll, P.C.; Woscholski, R.; Parker, P.J.; Waterfield, M.D.
Synthesis and function of 3-phosphorylated inositol lipids
Annu. Rev. Biochem.
70
535-602
2001
Caenorhabditis elegans, Dictyostelium discoideum, Drosophila melanogaster, Homo sapiens, Mammalia
Manually annotated by BRENDA team
Vanhaesebroeck, B.; Leevers, S.J.; Panayotou, G.; Waterfield, M.D.
Phosphoinositide 3-kinases: a conserved family of signal transducers
Trends Biochem. Sci.
22
267-272
1997
Mammalia
Manually annotated by BRENDA team
Hruska, K.A.; Rolnick, F.; Huskey, M.; Alvarez, U.; Cheresh, D.
Engagement of the osteoclast integrin alphavbeta3 by osteopontin stimulates phosphatidylinositol 3-hydroxyl kinase activity
Endocrinology
136
2984-2992
1995
Gallus gallus
Manually annotated by BRENDA team
Metzner, B.; Heger, M.; Hofmann, C.; Czech, W.; Norgauer, J.
Evidence for the involvement of phosphatidylinositol 4,5-bisphosphate 3-kinase in CD18-mediated adhesion of human neutrophils to fibrinogen
Biochem. Biophys. Res. Commun.
232
719-723
1997
Homo sapiens
Manually annotated by BRENDA team
Hawkins, P.T.; Jackson, T.R.; Stephens, L.R.
Platelet-derived growth factor stimulates synthesis of PtdIns(3,4,5)P3 by activating a PtdIns(4,5)P2 3-OH kinase
Nature
358
157-159
1992
Mus musculus
Manually annotated by BRENDA team
Vanhaesebroeck, B.; Welham, M.J.; Kotani, K.; Stein, R.; Warne, P.H.; Zvelebil, M.J.; Higashi, K.; Volinia, S.; Downward, J.; Waterfield, M.D.
P110delta, a novel phosphoinositide 3-kinase in leukocytes
Proc. Natl. Acad. Sci. USA
94
4330-4335
1997
Homo sapiens (O00329)
Manually annotated by BRENDA team
Chantry, D.; Vojtek, A.; Kashishian, A.; Holtzman, D.A.; Wood, C.; Gray, P.W.; Cooper, J.A.; Hoekstra, M.F.
p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes
J. Biol. Chem.
272
19236-19241
1997
Homo sapiens (O00329), Homo sapiens
Manually annotated by BRENDA team
Lu, P.J.; Hsu, A.L.; Wang, D.S.; Yan, H.Y.; Yin, H.L.; Chen, C.S.
Phosphoinositide 3-kinase in rat liver nuclei
Biochemistry
37
5738-5745
1998
Rattus norvegicus
Manually annotated by BRENDA team
Stoyanov, B.; Volinia, S.; Hanck, T.; Rubio, I.; Loubtchenkov, M.; Malek, D.; Stoyanova, S.; Vanhaesebroeck, B.; Dhand, R.; et al.
Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase
Science
269
690-693
1995
Homo sapiens (P48736)
Manually annotated by BRENDA team
Klippel, A.; Escobedo, J.A.; Hirano, M.; Williams, L.T.
The interaction of small domains between the subunits of phosphatidylinositol 3-kinase determines enzyme activity
Mol. Cell. Biol.
14
2675-2685
1994
Mus musculus (P42337), Mus musculus
Manually annotated by BRENDA team
Stirdivant, S.M.; Ahern, J.; Conroy, R.R.; Barnett, S.F.; Ledder, L.M.; Oliff, A.; Heimbrook, D.C.
Cloning and mutagenesis of the p110 alpha subunit of human phosphoinositide 3'-hydroxykinase
Bioorg. Med. Chem.
5
65-74
1997
Homo sapiens (P42336)
Manually annotated by BRENDA team
Turner, S.J.; Domin, J.; Waterfield, M.D.; Ward, S.G.; Westwick, J.
The CC chemokine monocyte chemotactic peptide-1 activates both the class I p85/p110 phosphatidylinositol 3-kinase and the class II PI3K-C2alpha
J. Biol. Chem.
273
25987-25995
1998
Homo sapiens
Manually annotated by BRENDA team
Jackson, S.P.; Schoenwaelder, S.M.; Matzaris, M.; Brown, S.; Mitchell, C.A.
Phosphatidylinositol 3,4,5-trisphosphate is a substrate for the 75 kDa inositol polyphosphate 5-phosphatase and a novel 5-phosphatase which forms a complex with the p85/p110 form of phosphoinositide 3-kinase
EMBO J.
14
4490-4500
1995
Homo sapiens
Manually annotated by BRENDA team
Kurosu, H.; Katada, T.
Association of phosphatidylinositol 3-kinase composed of p110beta-catalytic and p85-regulatory subunits with the small GTPase Rab5
J. Biochem.
130
73-78
2001
Homo sapiens
Manually annotated by BRENDA team
Maier, U.; Babich, A.; Nurnberg, B.
Roles of non-catalytic subunits in Gbg-induced activation of class I phosphoinositide 3-kinase isoforms b and g
J. Biol. Chem.
274
29311-29317
1999
Homo sapiens (P48736)
Manually annotated by BRENDA team
Brock, C.; Schaefer, M.; Reusch, H.P.; Czupalla, C.; Michalke, M.; Spicher, K.; Schultz, G.; Nurnberg, B.
Roles of Gbg in membrane recruitment and activation of p110gamma/p101 phosphoinositide 3-kinase gamma
J. Cell Biol.
160
89-99
2003
Homo sapiens (P48736)
Manually annotated by BRENDA team
Luo, J.; Field, S.J.; Lee, J.Y.; Engelman, J.A.; Cantley, L.C.
The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex
J. Cell Biol.
170
455-464
2005
Mus musculus
Manually annotated by BRENDA team
Hu, P.; Mondino, A.; Skolnik, E.Y.; Schlessinger, J.
Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85
Mol. Cell. Biol.
13
7677-7688
1993
Homo sapiens (P42338), Homo sapiens
Manually annotated by BRENDA team
Ueki, K.; Fruman, D.A.; Brachmann, S.M.; Tseng, Y.H.; Cantley, L.C.; Kahn, C.R.
Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival
Mol. Cell. Biol.
22
965-977
2002
Mus musculus
Manually annotated by BRENDA team
Morris, A.J.; Rudge, S.A.; Mahlum, C.E.; Jenco.John, M.
Regulation of phosphoinositide-3-kinase by G protein bg subunits in a rat osteosarcoma cell line
Mol. Pharmacol.
48
532-539
1995
Rattus norvegicus (Q9Z1L0)
Manually annotated by BRENDA team
Patton, D.T.; Garcon, F.; Okkenhaug, K.
The PI3K p110delta controls T-cell development, differentiation and regulation
Biochem. Soc. Trans.
35
167-171
2007
Mus musculus (O35904)
Manually annotated by BRENDA team
Liu, L.; Puri, K.D.; Penninger, J.M.; Kubes, P.
Leukocyte PI3Kgamma and PI3Kdelta have temporally distinct roles for leukocyte recruitment in vivo
Blood
110
1191-1198
2007
Mus musculus (O35904), Mus musculus (Q9JHG7)
Manually annotated by BRENDA team
Papakonstanti, E.A.; Ridley, A.J.; Vanhaesebroeck, B.
The p110delta isoform of PI 3-kinase negatively controls RhoA and PTEN
EMBO J.
26
3050-3061
2007
Mus musculus (O35904)
Manually annotated by BRENDA team
Nashed, B.F.; Zhang, T.; Al-Alwan, M.; Srinivasan, G.; Halayko, A.J.; Okkenhaug, K.; Vanhaesebroeck, B.; Hayglass, K.T.; Marshall, A.J.
Role of the phosphoinositide 3-kinase p110delta in generation of type 2 cytokine responses and allergic airway inflammation
Eur. J. Immunol.
37
416-424
2007
Mus musculus (O35904)
Manually annotated by BRENDA team
Okkenhaug, K.; Patton, D.T.; Bilancio, A.; Garcon, F.; Rowan, W.C.; Vanhaesebroeck, B.
The p110delta isoform of phosphoinositide 3-kinase controls clonal expansion and differentiation of Th cells
J. Immunol.
177
5122-5128
2006
Mus musculus (O35904)
Manually annotated by BRENDA team
Llorian, M.; Stamataki, Z.; Hill, S.; Turner, M.; Martensson, I.L.
The PI3K p110delta is required for down-regulation of RAG expression in immature B cells
J. Immunol.
178
1981-1985
2007
Mus musculus (O35904)
Manually annotated by BRENDA team
Eickholt, B.J.; Ahmed, A.I.; Davies, M.; Papakonstanti, E.A.; Pearce, W.; Starkey, M.L.; Bilancio, A.; Need, A.C.; Smith, A.J.; Hall, S.M.; Hamers, F.P.; Giese, K.P.; Bradbury, E.J.; Vanhaesebroeck, B.
Control of axonal growth and regeneration of sensory neurons by the p110delta PI 3-kinase
PLoS ONE
2
e869
2007
Mus musculus
Manually annotated by BRENDA team
Okkenhaug, K.; Ali, K.; Vanhaesebroeck, B.
Antigen receptor signalling: a distinctive role for the p110delta isoform of PI3K
Trends Immunol.
28
80-87
2007
Mus musculus (O35904)
Manually annotated by BRENDA team
Raynaud, F.I.; Eccles, S.; Clarke, P.A.; Hayes, A.; Nutley, B.; Alix, S.; Henley, A.; Di-Stefano, F.; Ahmad, Z.; Guillard, S.; Bjerke, L.M.; Kelland, L.; Valenti, M.; Patterson, L.; Gowan, S.; de Haven Brandon, A.; Hayakawa, M.; Kaizawa, H.; Koizumi, T.; Ohishi, T.; Patel, S.; Saghir, N.; Parker, P.; Waterfield, M.; Workman, P.
Pharmacologic characterization of a potent inhibitor of class I phosphatidylinositide 3-kinases
Cancer Res.
67
5840-5850
2007
Homo sapiens
Manually annotated by BRENDA team
Randis, T.M.; Puri, K.D.; Zhou, H.; Diacovo, T.G.
Role of PI3Kdelta and PI3Kgamma in inflammatory arthritis and tissue localization of neutrophils
Eur. J. Immunol.
38
1215-1224
2008
Mus musculus
Manually annotated by BRENDA team
Shiroki, F.; Matsuda, S.; Doi, T.; Fujiwara, M.; Mochizuki, Y.; Kadowaki, T.; Suzuki, H.; Koyasu, S.
The p85alpha regulatory subunit of class IA phosphoinositide 3-kinase regulates beta-selection in thymocyte development
J. Immunol.
178
1349-1356
2007
Mus musculus
Manually annotated by BRENDA team
Park, S.; Chapuis, N.; Bardet, V.; Tamburini, J.; Gallay, N.; Willems, L.; Knight, Z.A.; Shokat, K.M.; Azar, N.; Viguie, F.; Ifrah, N.; Dreyfus, F.; Mayeux, P.; Lacombe, C.; Bouscary, D.
PI-103, a dual inhibitor of class IA phosphatidylinositide 3-kinase and mTOR, has antileukemic activity in AML
Leukemia
22
1698-1706
2008
Homo sapiens
Manually annotated by BRENDA team
Farghaly, H.S.; Blagbrough, I.S.; Medina-Tato, D.A.; Watson, M.L.
Interleukin 13 increases contractility of murine tracheal smooth muscle by a phosphoinositide 3-kinase p110delta-dependent mechanism
Mol. Pharmacol.
73
1530-1537
2008
Mus musculus
Manually annotated by BRENDA team
Geering, B.; Cutillas, P.R.; Nock, G.; Gharbi, S.I.; Vanhaesebroeck, B.
Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers
Proc. Natl. Acad. Sci. USA
104
7809-7814
2007
Mus musculus
Manually annotated by BRENDA team
Preuss, I.; Kurig, B.; Nuernberg, B.; Orth, J.H.; Aktories, K.
Pasteurella multocida toxin activates Gbetagamma dimers of heterotrimeric G proteins
Cell. Signal.
21
551-558
2009
Homo sapiens
Manually annotated by BRENDA team
Mammadova, G.; Iwasaki, T.; Tokmakov, A.A.; Fukami, Y.; Sato, K.I.
Evidence that phosphatidylinositol 3-kinase is involved in sperm-induced tyrosine kinase signaling in Xenopus egg fertilization
BMC Dev. Biol.
9
68
2009
Xenopus laevis
Manually annotated by BRENDA team
Knowles, M.A.; Platt, F.M.; Ross, R.L.; Hurst, C.D.
Phosphatidylinositol 3-kinase (PI3K) pathway activation in bladder cancer
Cancer Metastasis Rev.
28
305-316
2009
Homo sapiens
Manually annotated by BRENDA team
Renner, O.; Blanco-Aparicio, C.; Grassow, M.; Canamero, M.; Leal, J.F.; Carnero, A.
Activation of phosphatidylinositol 3-kinase by membrane localization of p110alpha predisposes mammary glands to neoplastic transformation
Cancer Res.
68
9643-9653
2008
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Chiarini, F.; Fala, F.; Tazzari, P.L.; Ricci, F.; Astolfi, A.; Pession, A.; Pagliaro, P.; McCubrey, J.A.; Martelli, A.M.
Dual inhibition of class IA phosphatidylinositol 3-kinase and mammalian target of rapamycin as a new therapeutic option for T-cell acute lymphoblastic leukemia
Cancer Res.
69
3520-3528
2009
Homo sapiens
Manually annotated by BRENDA team
Psyrri, A.; Papageorgiou, S.; Liakata, E.; Scorilas, A.; Rontogianni, D.; Kontos, C.K.; Argyriou, P.; Pectasides, D.; Harhalakis, N.; Pappa, V.; Kolialexi, A.; Economopoulou, C.; Kontsioti, F.; Maratou, E.; Dimitriadis, G.; Economopoulou, P.; Economopoulos, T.
Phosphatidylinositol 3-kinase catalytic subunit alpha gene amplification contributes to the pathogenesis of mantle cell lymphoma
Clin. Cancer Res.
15
5724-5732
2009
Homo sapiens
Manually annotated by BRENDA team
Fukushima, T.; Nedachi, T.; Akizawa, H.; Akahori, M.; Hakuno, F.; Takahashi, S.
Distinct modes of activation of phosphatidylinositol 3-kinase in response to cyclic adenosine 3',5'-monophosphate or insulin-like growth factor I play different roles in regulation of cyclin D1 and p27Kip1 in FRTL-5 cells
Endocrinology
149
3729-3742
2008
Rattus norvegicus
Manually annotated by BRENDA team
Rivard, N.
Phosphatidylinositol 3-kinase: a key regulator in adherens junction formation and function
Front. Biosci.
14
510-522
2009
Canis lupus familiaris, Homo sapiens
Manually annotated by BRENDA team
Kim, J.J.; Choi, Y.M.; Hong, M.A.; Hwang, S.S.; Yoon, S.H.; Chae, S.J.; Jee, B.C.; Ku, S.Y.; Kim, J.G.; Moon, S.Y.
Phosphatidylinositol 3-kinase p85alpha regulatory subunit gene Met326Ile polymorphism in women with polycystic ovary syndrome
Hum. Reprod.
24
1184-1190
2009
Homo sapiens
Manually annotated by BRENDA team
Zubcevic, J.; Waki, H.; Diez-Freire, C.; Gampel, A.; Raizada, M.K.; Paton, J.F.
Chronic blockade of phosphatidylinositol 3-kinase in the nucleus tractus solitarii is prohypertensive in the spontaneously hypertensive rat
Hypertension
53
97-103
2009
Rattus norvegicus
Manually annotated by BRENDA team
Hwang, M.K.; Song, N.R.; Kang, N.J.; Lee, K.W.; Lee, H.J.
Activation of phosphatidylinositol 3-kinase is required for tumor necrosis factor-alpha-induced upregulation of matrix metalloproteinase-9: its direct inhibition by quercetin
Int. J. Biochem. Cell Biol.
41
1592-1600
2009
Mus musculus
Manually annotated by BRENDA team
Chamberlain, M.D.; Chan, T.; Oberg, J.C.; Hawrysh, A.D.; James, K.M.; Saxena, A.; Xiang, J.; Anderson, D.H.
Disrupted RabGAP function of the p85 subunit of phosphatidylinositol 3-kinase results in cell transformation
J. Biol. Chem.
283
15861-15868
2008
Homo sapiens
Manually annotated by BRENDA team
Li, Y.; Anderson, D.H.; Liu, Q.; Zhou, Y.
Mechanism of influenza A virus NS1 protein interaction with the p85beta, but not the p85alpha, subunit of phosphatidylinositol 3-kinase (PI3K) and up-regulation of PI3K activity
J. Biol. Chem.
283
23397-23409
2008
Bos taurus, Mus musculus
Manually annotated by BRENDA team
Cammer, M.; Gevrey, J.C.; Lorenz, M.; Dovas, A.; Condeelis, J.; Cox, D.
The mechanism of CSF-1-induced Wiskott-Aldrich syndrome protein activation in vivo: a role for phosphatidylinositol 3-kinase and Cdc42
J. Biol. Chem.
284
23302-23311
2009
Homo sapiens
Manually annotated by BRENDA team
Desai, L.P.; White, S.R.; Waters, C.M.
Cyclic mechanical stretch decreases cell migration by inhibiting phosphatidylinositol 3-kinase (PI3-kinase) and focal adhesion kinase (FAK) mediated c-Jun N-terminal kinase-1 (JNK1) activation
J. Biol. Chem.
285
4511-4519
2009
Homo sapiens
Manually annotated by BRENDA team
Li, L.; Saga, N.; Mikami, K.
Phosphatidylinositol 3-kinase activity and asymmetrical accumulation of F-actin are necessary for establishment of cell polarity in the early development of monospores from the marine red alga Porphyra yezoensis
J. Exp. Bot.
59
3575-3586
2008
Neopyropia yezoensis, Neopyropia yezoensis TU-1
Manually annotated by BRENDA team
Martin, A.L.; Schwartz, M.D.; Jameson, S.C.; Shimizu, Y.
Selective regulation of CD8 effector T cell migration by the p110 gamma isoform of phosphatidylinositol 3-kinase
J. Immunol.
180
2081-2088
2008
Mus musculus, Mus musculus C57BL/6
Manually annotated by BRENDA team
Kaur, S.; Sassano, A.; Joseph, A.M.; Majchrzak-Kita, B.; Eklund, E.A.; Verma, A.; Brachmann, S.M.; Fish, E.N.; Platanias, L.C.
Dual regulatory roles of phosphatidylinositol 3-kinase in IFN signaling
J. Immunol.
181
7316-7323
2008
Mus musculus
Manually annotated by BRENDA team
Liu, D.; Zhang, T.; Marshall, A.J.; Okkenhaug, K.; Vanhaesebroeck, B.; Uzonna, J.E.
The p110delta isoform of phosphatidylinositol 3-kinase controls susceptibility to Leishmania major by regulating expansion and tissue homing of regulatory T cells
J. Immunol.
183
1921-1933
2009
Mus musculus
Manually annotated by BRENDA team
Thomas, M.S.; Mitchell, J.S.; DeNucci, C.C.; Martin, A.L.; Shimizu, Y.
The p110gamma isoform of phosphatidylinositol 3-kinase regulates migration of effector CD4 T lymphocytes into peripheral inflammatory sites
J. Leukoc. Biol.
84
814-823
2008
Mus musculus
Manually annotated by BRENDA team
Ihle, N.T.; Powis, G.
Take your PIK: phosphatidylinositol 3-kinase inhibitors race through the clinic and toward cancer therapy
Mol. Cancer Ther.
8
1-9
2009
Homo sapiens
Manually annotated by BRENDA team
Munugalavadla, V.; Vemula, S.; Sims, E.C.; Krishnan, S.; Chen, S.; Yan, J.; Li, H.; Niziolek, P.J.; Takemoto, C.; Robling, A.G.; Yang, F.C.; Kapur, R.
The p85alpha subunit of class IA phosphatidylinositol 3-kinase regulates the expression of multiple genes involved in osteoclast maturation and migration
Mol. Cell. Biol.
28
7182-7198
2008
Homo sapiens
Manually annotated by BRENDA team
Gavard, J.; Hou, X.; Qu, Y.; Masedunskas, A.; Martin, D.; Weigert, R.; Li, X.; Gutkind, J.S.
A role for a CXCR2/phosphatidylinositol 3-kinase gamma signaling axis in acute and chronic vascular permeability
Mol. Cell. Biol.
29
2469-2480
2009
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Chen, B.C.; Kang, J.C.; Lu, Y.T.; Hsu, M.J.; Liao, C.C.; Chiu, W.T.; Yeh, F.L.; Lin, C.H.
Rac1 regulates peptidoglycan-induced nuclear factor-kappaB activation and cyclooxygenase-2 expression in RAW 264.7 macrophages by activating the phosphatidylinositol 3-kinase/Akt pathway
Mol. Immunol.
46
1179-1188
2009
Mus musculus
Manually annotated by BRENDA team
Zhang, X.; Deng, H.X.; Zhao, X.; Su, D.; Chen, X.C.; Chen, L.J.; Wei, Y.Q.; Zhong, Q.; Li, Z.Y.; He, X.; Yi, T.
RNA interference-mediated silencing of the phosphatidylinositol 3-kinase catalytic subunit attenuates growth of human ovarian cancer cells in vitroand in vivo
Oncology
77
22-32
2009
Homo sapiens
Manually annotated by BRENDA team
Yang, Y.; Iwanaga, K.; Raso, M.G.; Wislez, M.; Hanna, A.E.; Wieder, E.D.; Molldrem, J.J.; Wistuba, I.I.; Powis, G.; Demayo, F.J.; Kim, C.F.; Kurie, J.M.
Phosphatidylinositol 3-kinase mediates bronchioalveolar stem cell expansion in mouse models of oncogenic K-ras-induced lung cancer
PLoS ONE
3
e2220
2008
Mus musculus
Manually annotated by BRENDA team
Tachado, S.D.; Samrakandi, M.M.; Cirillo, J.D.
Non-opsonic phagocytosis of Legionella pneumophila by macrophages is mediated by phosphatidylinositol 3-kinase
PLoS ONE
3
e3324
2008
Homo sapiens
Manually annotated by BRENDA team
Zhao, L.; Vogt, P.K.
Helical domain and kinase domain mutations in p110alpha of phosphatidylinositol 3-kinase induce gain of function by different mechanisms
Proc. Natl. Acad. Sci. USA
105
2652-2657
2008
Homo sapiens
Manually annotated by BRENDA team
Akashi, T.; Yamori, T.
Proteomic analysis of phosphoproteins sensitive to a phosphatidylinositol 3-kinase inhibitor, ZSTK474, by using SELDI-TOF MS
Proteome Sci.
7
14
2009
Homo sapiens
Manually annotated by BRENDA team
Furuya, F.; Lu, C.; Guigon, C.J.; Cheng, S.Y.
Nongenomic activation of phosphatidylinositol 3-kinase signaling by thyroid hormone receptors
Steroids
74
628-634
2009
Mus musculus
Manually annotated by BRENDA team
Marwick, J.A.; Chung, K.F.; Adcock, I.M.
Phosphatidylinositol 3-kinase isoforms as targets in respiratory disease
Ther. Adv. Respir. Dis.
2009
1-16
2010
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Lin, H.; Erhard, K.; Hardwicke, M.A.; Luengo, J.I.; Mack, J.F.; McSurdy-Freed, J.; Plant, R.; Raha, K.; Rominger, C.M.; Sanchez, R.M.; Schaber, M.D.; Schulz, M.J.; Spengler, M.D.; Tedesco, R.; Xie, R.; Zeng, J.J.; Rivero, R.A.
Synthesis and structure-activity relationships of imidazo[1,2-a]pyrimidin-5(1H)-ones as a novel series of beta isoform selective phosphatidylinositol 3-kinase inhibitors
Bioorg. Med. Chem. Lett.
22
2230-2234
2012
Homo sapiens (P42338)
Manually annotated by BRENDA team
Sanchez, R.M.; Erhard, K.; Hardwicke, M.A.; Lin, H.; McSurdy-Freed, J.; Plant, R.; Raha, K.; Rominger, C.M.; Schaber, M.D.; Spengler, M.D.; Moore, M.L.; Yu, H.; Luengo, J.I.; Tedesco, R.; Rivero, R.A.
Synthesis and structure-activity relationships of 1,2,4-triazolo[1,5-a]pyrimidin-7(3H)-ones as novel series of potent beta isoform selective phosphatidylinositol 3-kinase inhibitors
Bioorg. Med. Chem. Lett.
22
3198-3202
2012
Homo sapiens (P42338)
Manually annotated by BRENDA team
Large, J.M.; Torr, J.E.; Raynaud, F.I.; Clarke, P.A.; Hayes, A.; Stefano, F.d.; Urban, F.; Shuttleworth, S.J.; Saghir, N.; Sheldrake, P.; Workman, P.; McDonald, E.
Preparation and evaluation of trisubstituted pyrimidines as phosphatidylinositol 3-kinase inhibitors. 3-Hydroxyphenol analogues and bioisosteric replacements
Bioorg. Med. Chem.
19
836-851
2011
Homo sapiens (P42336)
Manually annotated by BRENDA team
Lannutti, B.J.; Meadows, S.A.; Herman, S.E.; Kashishian, A.; Steiner, B.; Johnson, A.J.; Byrd, J.C.; Tyner, J.W.; Loriaux, M.M.; Deininger, M.; Druker, B.J.; Puri, K.D.; Ulrich, R.G.; Giese, N.A.
CAL-101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability
Blood
117
591-594
2011
Homo sapiens (O00329)
Manually annotated by BRENDA team
Gao, M.; Wang, J.; Wang, W.; Liu, J.; Wong, C.W.
Phosphatidylinositol 3-kinase affects mitochondrial function in part through inducing peroxisome proliferator-activated receptor gamma coactivator-1beta expression
Br. J. Pharmacol.
162
1000-1008
2011
Homo sapiens
Manually annotated by BRENDA team
Zwaenepoel, O.; Tzenaki, N.; Vergetaki, A.; Makrigiannakis, A.; Vanhaesebroeck, B.; Papakonstanti, E.A.
Functional CSF-1 receptors are located at the nuclear envelope and activated via the p110delta isoform of PI 3-kinase
FASEB J.
26
691-706
2012
Mus musculus
Manually annotated by BRENDA team
Wu, Y.; Tan, H.; Shui, G.; Bauvy, C.; Huang, Q.; Wenk, M.; Ong, C.; Codogno, P.; Shen, H.
Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinase
J. Biol. Chem.
285
10850-10861
2010
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Runyan, C.E.; Liu, Z.; Schnaper, H.W.
Phosphatidylinositol 3-kinase and Rab5 GTPase inversely regulate the Smad anchor for receptor activation (SARA) protein independently of transforming growth factor-beta1
J. Biol. Chem.
287
35815-35824
2012
Homo sapiens (P27986)
Manually annotated by BRENDA team
Fernandez-Acero, T.; Rodriguez-Escudero, I.; Vicente, F.; Monteiro, M.C.; Tormo, J.R.; Cantizani, J.; Molina, M.; Cid, V.J.
A yeast-based in vivo bioassay to screen for class I phosphatidylinositol 3-kinase specific inhibitors
J. Biomol. Screen.
17
1018-1029
2012
Homo sapiens (P42336)
Manually annotated by BRENDA team
Arancibia, S.; Beni­tez, D.; Nunez, L.; Jewell, C.; Langjahr, P.; Candia, E.; Zapata-Torres, G.; Cidlowski, J.; Gonzalez, M.; Hermoso, M.
Phosphatidylinositol 3-kinase interacts with the glucocorticoid receptor upon TLR2 activation
J. Cell. Mol. Med.
15
339-349
2011
Homo sapiens
Manually annotated by BRENDA team
Chen, Z.; Venkatesan, A.M.; Dehnhardt, C.M.; Ayral-Kaloustian, S.; Brooijmans, N.; Mallon, R.; Feldberg, L.; Hollander, I.; Lucas, J.; Yu, K.; Kong, F.; Mansour, T.S.
Synthesis and SAR of novel 4-morpholinopyrrolopyrimidine derivatives as potent phosphatidylinositol 3-kinase inhibitors
J. Med. Chem.
53
3169-3182
2010
Homo sapiens (P42336), Homo sapiens
Manually annotated by BRENDA team
Rewcastle, G.W.; Gamage, S.A.; Flanagan, J.U.; Frederick, R.; Denny, W.A.; Baguley, B.C.; Kestell, P.; Singh, R.; Kendall, J.D.; Marshall, E.S.; Lill, C.L.; Lee, W.J.; Kolekar, S.; Buchanan, C.M.; Jamieson, S.M.; Shepherd, P.R.
Synthesis and biological evaluation of novel analogues of the pan class I phosphatidylinositol 3-kinase (PI3K) inhibitor 2-(difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole (ZSTK474)
J. Med. Chem.
54
7105-7126
2011
Homo sapiens (P48736), Homo sapiens
Manually annotated by BRENDA team
Smith, A.L.; DAngelo, N.D.; Bo, Y.Y.; Booker, S.K.; Cee, V.J.; Herberich, B.; Hong, F.T.; Jackson, C.L.; Lanman, B.A.; Liu, L.; Nishimura, N.; Pettus, L.H.; Reed, A.B.; Tadesse, S. et al.
Structure-based design of a novel series of potent, selective inhibitors of the class I phosphatidylinositol 3-kinases
J. Med. Chem.
55
5188-5219
2012
Homo sapiens (P42336), Homo sapiens (P48736)
Manually annotated by BRENDA team
Moir, L.M.; Trian, T.; Ge, Q.; Shepherd, P.R.; Burgess, J.K.; Oliver, B.G.; Black, J.L.
Phosphatidylinositol 3-kinase isoform-specific effects in airway mesenchymal cell function
J. Pharmacol. Exp. Ther.
337
557-566
2011
Homo sapiens
Manually annotated by BRENDA team
Kong, D.; Zhang, Y.; Yamori, T.; Duan, H.; Jin, M.
Inhibitory activity of flavonoids against class I phosphatidylinositol 3-kinase isoforms
Molecules
16
5159-5167
2011
Homo sapiens
Manually annotated by BRENDA team
Vantler, M.; Jesus, J.; Leppaenen, O.; Scherner, M.; Berghausen, E.M.; Mustafov, L.; Chen, X.; Kramer, T.; Zierden, M.; Gerhardt, M.; Ten Freyhaus, H.; Blaschke, F.; Sterner-Kock, A.; Baldus, S.; Zhao, J.J.; Rosenkranz, S.
Class IA phosphatidylinositol 3-kinase isoform p110alpha mediates vascular remodeling
Arterioscler. Thromb. Vasc. Biol.
35
1434-1444
2015
Rattus norvegicus, Rattus norvegicus (A0A0G2K344), Rattus norvegicus (Q9Z1L0), Homo sapiens (O00329), Homo sapiens (P42336), Homo sapiens (P42338), Homo sapiens, Mus musculus (O35904), Mus musculus (P42337), Mus musculus
Manually annotated by BRENDA team
Dickson, J.; Lee, W.; Shepherd, P.; Buchanan, C.
Enzyme activity effects of N-terminal His-tag attached to catalytic sub-unit of phosphoinositide-3-kinase
Biosci. Rep.
33
857-863
2013
Homo sapiens (P27986 AND P42336), Homo sapiens (P42338 AND O00329)
-
Manually annotated by BRENDA team
Gupta, V.K.; Rajala, A.; Rajala, R.V.
Non-canonical regulation of phosphatidylinositol 3-kinase gamma isoform activity in retinal rod photoreceptor cells
Cell Commun. Signal.
13
7-7
2015
Mus musculus (Q9JHG7)
Manually annotated by BRENDA team
Fernandez-Acero, T.; Rodriguez-Escudero, I.; Molina, M.; Cid, V.J.
The yeast cell wall integrity pathway signals from recycling endosomes upon elimination of phosphatidylinositol (4,5)-bisphosphate by mammalian phosphatidylinositol 3-kinase
Cell. Signal.
27
2272-2284
2015
Homo sapiens (P42336 AND P27986)
Manually annotated by BRENDA team
Watson, L.J.; Alexander, K.M.; Mohan, M.L.; Bowman, A.L.; Mangmool, S.; Xiao, K.; Naga Prasad, S.V.; Rockman, H.A.
Phosphorylation of Src by phosphoinositide 3-kinase regulates beta-adrenergic receptor-mediated EGFR transactivation
Cell. Signal.
28
1580-1592
2016
Homo sapiens (P48736)
Manually annotated by BRENDA team
Echeverria, I.; Liu, Y.; Gabelli, S.; Amzel, L.
Oncogenic mutations weaken the interactions that stabilize the p110?-p85? heterodimer in phosphatidylinositol 3-kinase ?.
FEBS J.
282
3528-3542
2015
Homo sapiens (P42336)
Manually annotated by BRENDA team
Thapa, N.; Choi, S.; Tan, X.; Wise, T.; Anderson, R.A.
Phosphatidylinositol phosphate 5-kinase Igamma and phosphoinositide 3-kinase/Akt signaling couple to promote oncogenic growth
J. Biol. Chem.
290
18843-18854
2015
Homo sapiens (P42336), Homo sapiens (P42338)
Manually annotated by BRENDA team
Somoza, J.R.; Koditek, D.; Villasenor, A.G.; Novikov, N.; Wong, M.H.; Liclican, A.; Xing, W.; Lagpacan, L.; Wang, R.; Schultz, B.E.; Papalia, G.A.; Samuel, D.; Lad, L.; McGrath, M.E.
Structural, biochemical, and biophysical characterization of idelalisib binding to phosphoinositide 3-kinase delta
J. Biol. Chem.
290
8439-8446
2015
Homo sapiens (O00329), Homo sapiens
Manually annotated by BRENDA team
Thomas, D.; Powell, J.A.; Green, B.D.; Barry, E.F.; Ma, Y.; Woodcock, J.; Fitter, S.; Zannettino, A.C.; Pitson, S.M.; Hughes, T.P.; Lopez, A.F.; Shepherd, P.R.; Wei, A.H.; Ekert, P.G.; Guthridge, M.A.
Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival
PLoS Biol.
11
e1001515
2013
Homo sapiens (P42336), Homo sapiens
Manually annotated by BRENDA team
Lacerda-Queiroz, N.; Brant, F.; Rodrigues, D.H.; Vago, J.P.; Rachid, M.A.; Sousa, L.P.; Teixeira, M.M.; Teixeira, A.L.
Phosphatidylinositol 3-kinase gamma is required for the development of experimental cerebral malaria
PLoS ONE
10
e0119633
2015
Mus musculus, Mus musculus C57BL/6
Manually annotated by BRENDA team
Li, D.; Yang, J.; Ma, H.; Sun, C.; Feng, R.
Inositol polyphosphate-4-phosphatase type II and rucaparib treatment inhibit the growth of osteosarcoma cells dependent on phosphoinositide 3-kinase/protein kinase B pathway
J. Cell. Biochem.
119
9899-9909
2018
Homo sapiens
Manually annotated by BRENDA team
Pridham, K.J.; Varghese, R.T.; Sheng, Z.
The role of class IA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunits in glioblastoma
Front. Oncol.
7
312
2017
Homo sapiens (P42336 AND P42338 AND P48736 AND O00329)
Manually annotated by BRENDA team
Bhattacharya, S.; McElhanon, K.E.; Gushchina, L.V.; Weisleder, N.
Role of phosphatidylinositol-4,5-bisphosphate 3-kinase signaling in vesicular trafficking
Life Sci.
167
39-45
2016
Homo sapiens (P42336 AND P42338 AND P48736 AND O00329)
Manually annotated by BRENDA team
Denorme, P.; Morren, M.A.; Hollants, S.; Spaepen, M.; Suaer, K.; Zutterman, N.; Labarque, V.; Legius, E.; Brems, H.
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA)-related overgrowth spectrum A brief report
Pediatr. Dermatol.
35
e186-e188
2018
Homo sapiens (P42336)
Manually annotated by BRENDA team