2.7.1.151: inositol-polyphosphate multikinase

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For detailed information about inositol-polyphosphate multikinase, go to the full flat file.

Reaction

Synonyms

1,3,4,6-tetrakisphosphate 5-kinase, 5-kinase, Arg82, ArgRIII, ARGSIII, AtIpk2a, AtIpk2b, AtIpk2beta, HsIPMK, Impk, inositol 1,4,5-trisphosphate 3-kinase, inositol phosphate multikinase, inositol phosphate multikinase 2, inositol polyphosphate 6-/3-kinase, inositol polyphosphate kinase, inositol polyphosphate multikinase, Ins(1,4,5)P3 3-kinase, InsP4 5-kinase, IP3 3-kinase, IP3/IP4 6-/3-kinase, IP3K, IPK, Ipk2, Ipk2/Impk/IP3K, Ipk2a, Ipk2beta/IP3K, IPKII, IPMK, ITPK1, Kcs1, Kcs1p, More, phosphoinositol kinase, PI3K, StIPMK

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.1 Phosphotransferases with an alcohol group as acceptor

                2.7.1.151 inositol-polyphosphate multikinase

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Results	in table
5	Activating Compound
564	AA Sequence
8	Application
1	CAS Registry Number
26	Cloned(Commentary)
23	Cofactor
4	Crystallization (Commentary)
90	Disease/ Diagnostics
16	General Information
1	General Stability
7	IC50 Value
15	Inhibitors
8	kcat/KM [mM/s]
2	Ki Value [mM]
31	KM Value [mM]
16	Localization
21	Metals/Ions
6	Molecular Weight [Da]
79	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
46	Organism
5	Pathway
18	PDB ID
11	pH Optimum
9	Posttranslational Modification
36	Protein Variants
11	Purification (Commentary)
4	Reaction
9	Reaction Type
45	Reference
52	Source Tissue
17	Specific Activity [micromol/min/mg]
134	Substrates and Products (Substrate)
8	Subunits
109	Synonyms
1	Systematic Name
10	Temperature Optimum [°C]
1	Temperature Stability [°C]

Systematic Name

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Systematic Name on EC 2.7.1.151 - inositol-polyphosphate multikinase

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SYSTEMATIC NAME

IUBMB Comments

ATP:1D-myo-inositol-1,4,5-trisphosphate 6-phosphotransferase

This enzyme also phosphorylates Ins(1,4,5)P3 to Ins(1,3,4,5)P4, Ins(1,3,4,5)P4 to Ins(1,3,4,5,6)P5, and Ins(1,3,4,5,6)P4 to Ins(PP)P4, isomer unknown. The enzyme from the plant Arabidopsis thaliana can also phosphorylate Ins(1,3,4,6)P4 and Ins(1,2,3,4,6)P5 at the D-5-position to produce 1,3,4,5,6-pentakisphosphate and inositol hexakisphosphate (InsP6), respectively [3]. Yeast produce InsP6 from Ins(1,4,5)P3 by the actions of this enzyme and EC 2.7.1.158, inositol-pentakisphosphate 2-kinase [4].