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2.7.1.151: inositol-polyphosphate multikinase

This is an abbreviated version!
For detailed information about inositol-polyphosphate multikinase, go to the full flat file.

Word Map on EC 2.7.1.151

Reaction

ATP
+
1D-myo-inositol 1,4,5,6-tetrakisphosphate
=
ADP
 +
1D-myo-inositol 1,3,4,5,6-pentakisphosphate

Synonyms

1,3,4,6-tetrakisphosphate 5-kinase, 5-kinase, Arg82, ArgRIII, ARGSIII, AtIpk2a, AtIpk2b, AtIpk2beta, HsIPMK, Impk, inositol 1,4,5-trisphosphate 3-kinase, inositol phosphate multikinase, inositol phosphate multikinase 2, inositol polyphosphate 6-/3-kinase, inositol polyphosphate kinase, inositol polyphosphate multikinase, Ins(1,4,5)P3 3-kinase, InsP4 5-kinase, IP3 3-kinase, IP3/IP4 6-/3-kinase, IP3K, IPK, Ipk2, Ipk2/Impk/IP3K, Ipk2a, Ipk2beta/IP3K, IPKII, IPMK, ITPK1, Kcs1, Kcs1p, More, phosphoinositol kinase, PI3K, StIPMK

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.151 inositol-polyphosphate multikinase

Reference

topprint

Reference on EC 2.7.1.151 - inositol-polyphosphate multikinase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Chakrabarti, S.; Biswas, B.B.
Metabolism of inositol phosphates. Part XIV. Evidence for the existence of a phosphoinositol kinase in chicken erythrocytes
Indian J. Biochem. Biophys.
18
398-401
1981
Gallus gallus
Manually annotated by BRENDA team
Yotsushima, K.; Mitsui, T.; Hayakawa, T.
Purification of phosphoinositol kinase from suspension-cultured cells of rice (Oryza sativa L.)
Biosci. Biotechnol. Biochem.
59
1953-1955
1995
Oryza sativa
-
Manually annotated by BRENDA team
Saiardi, A.; Erdjument-Bromage, H.; Snowman, A.M.; Tempst, P.; Snyder, S.H.
Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases
Curr. Biol.
9
1323-1326
1999
Saccharomyces cerevisiae
Manually annotated by BRENDA team
York, J.D.; Odom, A.R.; Murphy, R.; Ives, E.B.; Wente, S.R.
A phospholipase C-dependent inositol polyphosphate kinase pathway required for efficient messenger RNA export
Science
285
96-100
1999
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Saiardi, A.; Caffrey, J.J.; Snyder, S.H.; Shears, S.B.
Corrigendum to: activation of interstitial collagenase, MMP-1, by staphylococcus aureus cells having surface-bound plasmin: a novel role of plasminogen receptors of bacteria
FEBS Lett.
469
213
2000
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Saiardi, A.; Nagata, E.; Luo, H.R.; Sawa, A.; Luo, X.; Snowman, A.M.; Snyder, S.H.
Mammalian inositol polyphosphate multikinase synthesizes inositol 1,4,5-trisphosphate and an inositol pyrophosphate
Proc. Natl. Acad. Sci. USA
98
2306-2311
2001
Rattus norvegicus (Q99NI4)
Manually annotated by BRENDA team
Chang, S.C.; Miller, A.L.; Feng, Y.; Wente, S.R.; Majerus, P.W.
The human homolog of the rat inositol phosphate multikinase is an inositol 1,3,4,6-tetrakisphosphate 5-kinase
J. Biol. Chem.
277
43836-43843
2002
Homo sapiens
Manually annotated by BRENDA team
Chang, S.C.; Majerus, P.W.
Inositol polyphosphate multikinase regulates inositol 1,4,5,6-tetrakisphosphate
Biochem. Biophys. Res. Commun.
339
209-216
2006
Homo sapiens
Manually annotated by BRENDA team
Nalaskowski, M.M.; Deschermeier, C.; Fanick, W.; Mayr, G.W.
The human homologue of yeast ArgRIII protein is an inositol phosphate multikinase with predominantly nuclear localization
Biochem. J.
366
549-556
2002
Homo sapiens (Q8NFU5), Homo sapiens
Manually annotated by BRENDA team
Xia, H.J.; Yang, G.
Inositol 1,4,5-trisphosphate 3-kinases: functions and regulations
Cell Res.
15
83-91
2005
Arabidopsis thaliana, Saccharomyces cerevisiae, Homo sapiens
Manually annotated by BRENDA team
Dubois, E.; Scherens, B.; Vierendeels, F.; Ho, M.M.W.; Messenguy, F.; Shears, S.B.
In Saccharomyces cerevisiae, the inositol polyphosphate kinase activity of Kcs1p is required for resistance to salt stress, cell wall integrity, and vacuolar morphogenesis
J. Biol. Chem.
277
23755-23763
2002
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Stevenson-Paulik, J.; Odom, A.R.; York, J.D.
Molecular and biochemical characterization of two plant inositol polyphosphate 6-/3-/5-kinases
J. Biol. Chem.
277
42711-42718
2002
Arabidopsis thaliana (Q9FLT2), Arabidopsis thaliana (Q9LY23), Arabidopsis thaliana
Manually annotated by BRENDA team
Mayr, G.W.; Windhorst, S.; Hillemeier, K.
Antiproliferative plant and synthetic polyphenolics are specific inhibitors of vertebrate inositol-1,4,5-trisphosphate 3-kinases and inositol polyphosphate multikinase
J. Biol. Chem.
280
13229-13240
2005
Homo sapiens
Manually annotated by BRENDA team
Seeds, A.M.; Bastidas, R.J.; York, J.D.
Molecular definition of a novel inositol polyphosphate metabolic pathway initiated by inositol 1,4,5-trisphosphate 3-kinase activity in Saccharomyces cerevisiae
J. Biol. Chem.
280
27654-27661
2005
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Resnick, A.C.; Snowman, A.M.; Kang, B.N.; Hurt, K.J.; Snyder, S.H.; Saiardi, A.
Inositol polyphosphate multikinase is a nuclear PI3-kinase with transcriptional regulatory activity
Proc. Natl. Acad. Sci. USA
102
12783-12788
2005
Rattus norvegicus, Saccharomyces cerevisiae
Manually annotated by BRENDA team
Saiardi, A.; Resnick, A.C.; Snowman, A.M.; Wendland, B.; Snyder, S.H.
Inositol pyrophosphates regulate cell death and telomere length through phosphoinositide 3-kinase-related protein kinases
Proc. Natl. Acad. Sci. USA
102
1911-1914
2005
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Frederick, J.P.; Mattiske, D.; Wofford, J.A.; Megosh, L.C.; Drake, L.Y.; Chiou, S.T.; Hogan, B.L.; York, J.D.
An essential role for an inositol polyphosphate multikinase, Ipk2, in mouse embryogenesis and second messenger production
Proc. Natl. Acad. Sci. USA
102
8454-8459
2005
Mus musculus
Manually annotated by BRENDA team
Caddick, S.E.; Harrison, C.J.; Stavridou, I.; Johnson, S.; Brearley, C.A.
A lysine accumulation phenotype of ScIpk2Delta mutant yeast is rescued by Solanum tuberosum inositol phosphate multikinase
Biochem. J.
403
381-389
2007
Solanum tuberosum (A4H2J1), Solanum tuberosum
Manually annotated by BRENDA team
Leyman, A.; Pouillon, V.; Bostan, A.; Schurmans, S.; Erneux, C.; Pesesse, X.
The absence of expression of the three isoenzymes of the inositol 1,4,5-trisphosphate 3-kinase does not prevent the formation of inositol pentakisphosphate and hexakisphosphate in mouse embryonic fibroblasts
Cell. Signal.
19
1497-1504
2007
Mus musculus (Q7TT16), Mus musculus
Manually annotated by BRENDA team
Riley, A.M.; Deleu, S.; Qian, X.; Mitchell, J.; Chung, S.; Adelt, S.; Vogel, G.; Potter, B.V.; Shears, S.B.
On the contribution of stereochemistry to human ITPK1 specificity: Ins(1,4,5,6)P4 is not a physiologic substrate
FEBS Lett.
580
324-330
2006
Homo sapiens
Manually annotated by BRENDA team
Holmes, W.; Jogl, G.
Crystal structure of inositol phosphate multikinase 2 and implications for substrate specificity
J. Biol. Chem.
281
38109-38116
2006
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Gao, Y.; Wang, H.Y.
Inositol pentakisphosphate mediates Wnt/beta-catenin signaling
J. Biol. Chem.
282
26490-26502
2007
Mus musculus
Manually annotated by BRENDA team
Resnick, A.C.; Saiardi, A.
Inositol polyphosphate multikinase: metabolic architect of nuclear inositides
Front. Biosci.
13
856-866
2008
Arabidopsis thaliana, Saccharomyces cerevisiae, Drosophila melanogaster, Homo sapiens, Rattus norvegicus, Solanum tuberosum
Manually annotated by BRENDA team
Yang, L.; Tang, R.; Zhu, J.; Liu, H.; Mueller-Roeber, B.; Xia, H.; Zhang, H.
Enhancement of stress tolerance in transgenic tobacco plants constitutively expressing AtIpk2beta, an inositol polyphosphate 6-/3-kinase from Arabidopsis thaliana
Plant Mol. Biol.
66
329-343
2008
Arabidopsis thaliana
Manually annotated by BRENDA team
Zhang, Z.B.; Yang, G.; Arana, F.; Chen, Z.; Li, Y.; Xia, H.J.
Arabidopsis inositol polyphosphate 6-/3-kinase (AtIpk2beta) is involved in axillary shoot branching via auxin signaling
Plant Physiol.
144
942-951
2007
Arabidopsis thaliana (Q9LY23)
Manually annotated by BRENDA team
Zhang, Y.; Liu, H.; Li, B.; Zhang, J.T.; Li, Y.; Zhang, H.
Generation of selectable marker-free transgenic tomato resistant to drought, cold and oxidative stress using the Cre/loxP DNA excision system
Transgenic Res.
18
607-619
2009
Arabidopsis thaliana (Q9FLT2), Arabidopsis thaliana
Manually annotated by BRENDA team
Kim, S.; Kim, S.F.; Maag, D.; Maxwell, M.J.; Resnick, A.C.; Juluri, K.R.; Chakraborty, A.; Koldobskiy, M.A.; Cha, S.H.; Barrow, R.; Snowman, A.M.; Snyder, S.H.
Amino acid signaling to mTOR mediated by inositol polyphosphate multikinase
Cell Metab.
13
215-221
2011
Mus musculus
Manually annotated by BRENDA team
Endo-Streeter, S.; Tsui, M.K.; Odom, A.R.; Block, J.; York, J.D.
Structural studies and protein engineering of inositol phosphate multikinase
J. Biol. Chem.
287
35360-35369
2012
Arabidopsis thaliana (Q9LY23), Arabidopsis thaliana
Manually annotated by BRENDA team
Maag, D.; Maxwell, M.J.; Hardesty, D.A.; Boucher, K.L.; Choudhari, N.; Hanno, A.G.; Ma, J.F.; Snowman, A.S.; Pietropaoli, J.W.; Xu, R.; Storm, P.B.; Saiardi, A.; Snyder, S.H.; Resnick, A.C.
Inositol polyphosphate multikinase is a physiologic PI3-kinase that activates Akt/PKB
Proc. Natl. Acad. Sci. USA
108
1391-1396
2011
Mus musculus
Manually annotated by BRENDA team
Bang, S.; Kim, S.; Dailey, M.J.; Chen, Y.; Moran, T.H.; Snyder, S.H.; Kim, S.F.
AMP-activated protein kinase is physiologically regulated by inositol polyphosphate multikinase
Proc. Natl. Acad. Sci. USA
109
616-620
2012
Mus musculus
Manually annotated by BRENDA team
Xu, R.; Snyder, S.
Gene transcription by p53 requires inositol polyphosphate multikinase as a co-activator
Cell Cycle
12
1819-1820
2013
Homo sapiens
Manually annotated by BRENDA team
Wickramasinghe, V.O.; Savill, J.M.; Chavali, S.; Jonsdottir, A.B.; Rajendra, E.; Gruener, T.; Laskey, R.A.; Babu, M.M.; Venkitaraman, A.R.
Human inositol polyphosphate multikinase regulates transcript-selective nuclear mRNA export to preserve genome integrity
Mol. Cell
51
737-750
2013
Homo sapiens (Q8NFU5), Homo sapiens
Manually annotated by BRENDA team
Xu, R.; Paul, B.D.; Smith, D.R.; Tyagi, R.; Rao, F.; Khan, A.B.; Blech, D.J.; Vandiver, M.S.; Harraz, M.M.; Guha, P.; Ahmed, I.; Sen, N.; Gallagher, M.; Snyder, S.H.
Inositol polyphosphate multikinase is a transcriptional coactivator required for immediate early gene induction
Proc. Natl. Acad. Sci. USA
110
16181-16186
2013
Mus musculus (Q7TT16)
Manually annotated by BRENDA team
Ahmed, I.; Sbodio, J.I.; Harraz, M.M.; Tyagi, R.; Grima, J.C.; Albacarys, L.K.; Hubbi, M.E.; Xu, R.; Kim, S.; Paul, B.D.; Snyder, S.H.
Huntingtons disease: neural dysfunction linked to inositol polyphosphate multikinase
Proc. Natl. Acad. Sci. USA
112
9751-9756
2015
Homo sapiens (Q8NFU5), Homo sapiens
Manually annotated by BRENDA team
Xu, R.; Sen, N.; Paul, B.D.; Snowman, A.M.; Rao, F.; Vandiver, M.S.; Xu, J.; Snyder, S.H.
Inositol polyphosphate multikinase is a coactivator of p53-mediated transcription and cell death
Sci. Signal.
6
ra22
2013
Homo sapiens (Q8NFU5)
Manually annotated by BRENDA team
Wang, H.; Shears, S.B.
Structural features of human inositol phosphate multikinase rationalize its inositol phosphate kinase and phosphoinositide 3-kinase activities
J. Biol. Chem.
292
18192-18202
2017
Homo sapiens (Q8NFU5), Homo sapiens
Manually annotated by BRENDA team