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2.7.1.150: 1-phosphatidylinositol-3-phosphate 5-kinase

This is an abbreviated version!
For detailed information about 1-phosphatidylinositol-3-phosphate 5-kinase, go to the full flat file.

Word Map on EC 2.7.1.150

Reaction

ATP
+
1-phosphatidyl-1D-myo-inositol 3-phosphate
=
ADP
 +
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate

Synonyms

CgFab1, class III lipid kinase, Fab1, Fab1 phosphatidylinositol 3-phosphate 5-kinase, FAB1/FYVE finger-containing phosphoinositide kinase, Fab1/PIKfyve, Fab1p, formation of aploid and binucleate cells1/FYVE finger-containing phosphoinositide kinase, FYVE domain-containing phosphatidylinositol 3-phosphate 5-kinase, kinase (phosphorylating), phosphatidylinositol 3-phosphate 5-, More, phosphatidylinositol 3-phosphate 5-kinase, phosphatidylinositol 5-OH kinase, phosphatidylinositol phosphate kinase 3, Phosphatidylinositol-3-phosphate 5-kinase, phosphatidylinositol-3-phosphate-5-kinase PIKfyve, phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, PI(3)P-5-kinase, PI-3P-5-kinase, PI3P 5-kinase, PI3P-5 kinase, PIKfyve, PIKfyve/Fab1p, PIP5K3, PPK-3, PtdIns 3-phosphate 5-kinase, PtdIns(3) 5-kinase, PtdIns(3)P 5-kinase, PtdIns3P 5-kinase, PtdIns3P 5-OH kinase, Ste12, type III PIP kinase

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.150 1-phosphatidylinositol-3-phosphate 5-kinase

Disease

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Disease on EC 2.7.1.150 - 1-phosphatidylinositol-3-phosphate 5-kinase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
1-phosphatidylinositol-3-phosphate 5-kinase deficiency
Cell-Wall-Degrading Enzymes Required for Virulence in the Host Selective Toxin-Producing Necrotroph Alternaria alternata of Citrus.
Class III PI 3-kinase is the main source of PtdIns3P substrate and membrane recruitment signal for PIKfyve constitutive function in podocyte endomembrane homeostasis.
Deletion of PIKfyve alters alveolar macrophage populations and exacerbates allergic inflammation in mice.
PIKfyve deficiency in myeloid cells impairs lysosomal homeostasis in macrophages and promotes systemic inflammation in mice.
Transcription factor STE12alpha has distinct roles in morphogenesis, virulence, and ecological fitness of the primary pathogenic yeast Cryptococcus gattii.
Acquired Immunodeficiency Syndrome
Trehalose limits opportunistic mycobacterial survival during HIV co-infection by reversing HIV-mediated autophagy block.
Adenocarcinoma
Combined Inhibition of p38MAPK and PIKfyve Synergistically Disrupts Autophagy to Selectively Target Cancer Cells.
Albuminuria
Nephron specific knockin of the PIKfyve binding deficient Vac14L156R mutant results in albuminuria and mesangial expansion.
Alzheimer Disease
A cell-permeable tool for analysing APP intracellular domain function and manipulation of PIKfyve activity.
APP controls the formation of PI(3,5)P(2) vesicles through its binding of the PIKfyve complex.
The amyloid precursor protein (APP) binds the PIKfyve complex and modulates its function.
Arthritis
Inhibition of c-Rel DNA binding is critical for the anti-inflammatory effects of novel PIKfyve inhibitor.
Autoimmune Diseases
Structure-activity relationship study, target identification, and pharmacological characterization of a small molecular IL-12/23 inhibitor, APY0201.
The Phosphoinositide Kinase PIKfyve Promotes Cathepsin-S-Mediated Major Histocompatibility Complex Class II Antigen Presentation.
Breast Neoplasms
The PIKfyve-ArPIKfyve-Sac3 triad in human breast cancer: Functional link between elevated Sac3 phosphatase and enhanced proliferation of triple negative cell lines.
Carcinogenesis
Elevated levels of PtdIns5P in NPM-ALK transformed cells: implication of PIKfyve.
The phosphoinositide kinase PIKfyve mediates epidermal growth factor receptor trafficking to the nucleus.
Carcinoma
The phosphoinositide kinase PIKfyve mediates epidermal growth factor receptor trafficking to the nucleus.
Carcinoma, Hepatocellular
Akebia saponin E, as a novel PIKfyve inhibitor, induces lysosome-associated cytoplasmic vacuolation to inhibit proliferation of hepatocellular carcinoma cells.
Carcinoma, Non-Small-Cell Lung
The effects of PIKfyve inhibitor YM201636 on claudins and malignancy potential of nonsmall cell cancer cells.
Cardiomyopathies
Inhibition of PIKfyve prevents myocardial apoptosis and hypertrophy through activation of SIRT3 in obese mice.
Corneal Dystrophies, Hereditary
A novel mutation (p.Glu1389AspfsX16) of the phosphoinositide kinase, FYVE finger containing gene found in a Japanese patient with fleck corneal dystrophy.
A novel PIKFYVE mutation in fleck corneal dystrophy.
Characterization of pip5k3 fleck corneal dystrophy-linked gene in zebrafish.
Corneal dystrophies.
Endosomal phosphoinositides and human diseases.
Identification of novel PIKFYVE gene mutations associated with Fleck corneal dystrophy.
Mutations in PIP5K3 are associated with François-Neetens mouchetée fleck corneal dystrophy.
COVID-19
PIKfyve: a lipid kinase target for COVID-19, cancer and neurodegenerative disorders.
Synergistic block of SARS-CoV-2 infection by combined drug inhibition of the host entry factors PIKfyve kinase and TMPRSS2 protease.
The Global Phosphorylation Landscape of SARS-CoV-2 Infection.
The PIKfyve Inhibitor Apilimod: A Double-Edged Sword against COVID-19.
Dystonia
Altered homodimer formation and increased iron accumulation in VAC14-related disease: Case report and review of the literature.
Endometrial Hyperplasia
Autophagy in the physiological endometrium and cancer.
Endometrial Neoplasms
Autophagy in the physiological endometrium and cancer.
Glucose Intolerance
Muscle-specific Pikfyve gene disruption causes glucose intolerance, insulin resistance, adiposity, and hyperinsulinemia but not muscle fiber-type switching.
Unexpected severe consequences of Pikfyve deletion by aP2- or Aq-promoter-driven Cre expression for glucose homeostasis and mammary gland development.
Hyperinsulinism
Muscle-specific Pikfyve gene disruption causes glucose intolerance, insulin resistance, adiposity, and hyperinsulinemia but not muscle fiber-type switching.
Hypopigmentation
PIKfyve complex regulates early melanosome homeostasis required for physiological amyloid formation.
Infections
An STE12 gene identified in the mycorrhizal fungus Glomus intraradices restores infectivity of a hemibiotrophic plant pathogen.
fost12, the Fusarium oxysporum homolog of the transcription factor Ste12, is upregulated during plant infection and required for virulence.
Inhibition of PIKfyve kinase prevents infection by EBOV and SARS-CoV-2.
Inhibition of PIKfyve kinase prevents infection by Zaire ebolavirus and SARS-CoV-2.
Loss of PIKfyve drives the spongiform degeneration in prion diseases.
PIKfyve/Fab1 is required for efficient V-ATPase and hydrolase delivery to phagosomes, phagosomal killing, and restriction of Legionella infection.
Proteoglycan-Dependent Endo-Lysosomal Fusion Affects Intracellular Survival of Salmonella Typhimurium in Epithelial Cells.
Relevance of the transcription factor PdSte12 in Penicillium digitatum conidiation and virulence during citrus fruit infection.
Ste12 transcription factor homologue CpST12 is down-regulated by hypovirus infection and required for virulence and female fertility of the chestnut blight fungus Cryphonectria parasitica.
Synergistic block of SARS-CoV-2 infection by combined drug inhibition of the host entry factors PIKfyve kinase and TMPRSS2 protease.
The phosphatidylinositol-3-phosphate 5-kinase inhibitor apilimod blocks filoviral entry and infection.
The role of mitogen-activated protein (MAP) kinase signalling components and the Ste12 transcription factor in germination and pathogenicity of Botrytis cinerea.
Transcription Factor CfSte12 of Colletotrichum fructicola Is a Key Regulator of Early Apple Glomerella Leaf Spot Pathogenesis.
Vaccinia Virus Infection Requires Maturation of Macropinosomes.
Infertility
A dominant truncation allele identifies a gene, STE20, that encodes a putative protein kinase necessary for mating in Saccharomyces cerevisiae.
Isolation of suppressor mutants of phosphatidylinositol 3-phosphate 5-kinase deficient cells in Schizosaccharomyces pombe.
Role of STE genes in the mating factor signaling pathway mediated by GPA1 in Saccharomyces cerevisiae.
Rst1 and Rst2 are required for the a/alpha diploid cell type in yeast.
Insulin Resistance
Muscle-specific Pikfyve gene disruption causes glucose intolerance, insulin resistance, adiposity, and hyperinsulinemia but not muscle fiber-type switching.
Unexpected severe consequences of Pikfyve deletion by aP2- or Aq-promoter-driven Cre expression for glucose homeostasis and mammary gland development.
Liver Neoplasms
Inhibition of PIKfyve using YM201636 suppresses the growth of liver cancer via the induction of autophagy.
Lung Neoplasms
The effects of PIKfyve inhibitor YM201636 on claudins and malignancy potential of nonsmall cell cancer cells.
Lymphoma, Non-Hodgkin
B-cell non-Hodgkin lymphoma: Selective vulnerability to PIKFYVE inhibition.
Identification of apilimod as a first-in-class PIKfyve kinase inhibitor for treatment of B-cell non-Hodgkin lymphoma.
Multiple Myeloma
Identification of PIKfyve kinase as a target in multiple myeloma.
Neoplasms
A Family of PIKFYVE Inhibitors with Therapeutic Potential Against Autophagy-Dependent Cancer Cells Disrupt Multiple Events in Lysosome Homeostasis.
Autophagy in the physiological endometrium and cancer.
B-cell non-Hodgkin lymphoma: Selective vulnerability to PIKFYVE inhibition.
Combined Inhibition of p38MAPK and PIKfyve Synergistically Disrupts Autophagy to Selectively Target Cancer Cells.
Elevated levels of PtdIns5P in NPM-ALK transformed cells: implication of PIKfyve.
Inhibition of PIKfyve using YM201636 suppresses the growth of liver cancer via the induction of autophagy.
PIKfyve inhibitor cytotoxicity requires AKT suppression and excessive cytoplasmic vacuolation.
PIKfyve, MTMR3 and their product PtdIns5P regulate cancer cell migration and invasion through activation of Rac1.
PIKfyve: a lipid kinase target for COVID-19, cancer and neurodegenerative disorders.
Small molecule PIKfyve inhibitors as cancer therapeutics: Translational promises and limitations.
The effects of PIKfyve inhibitor YM201636 on claudins and malignancy potential of nonsmall cell cancer cells.
The Phosphoinositide Kinase PIKfyve Promotes Cathepsin-S-Mediated Major Histocompatibility Complex Class II Antigen Presentation.
Neurodegenerative Diseases
PIKfyve: a lipid kinase target for COVID-19, cancer and neurodegenerative disorders.
Obesity
Inhibition of PIKfyve prevents myocardial apoptosis and hypertrophy through activation of SIRT3 in obese mice.
Osteosarcoma
TRIM68, PIKFYVE, and DYNLL2: The Possible Novel Autophagy- and Immunity-Associated Gene Biomarkers for Osteosarcoma Prognosis.
Pancreatitis
Early to Late Endosome Trafficking Controls Secretion and Zymogen Activation in Rodent and Human Pancreatic Acinar Cells.
phosphatidylinositol 3-kinase deficiency
Active vacuolar H+ ATPase and functional cycle of Rab5 are required for the vacuolation defect triggered by PtdIns(3,5)P2 loss under PIKfyve or Vps34 deficiency.
Pneumonia
Deletion of PIKfyve alters alveolar macrophage populations and exacerbates allergic inflammation in mice.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Transcriptional Regulation of PIK3CD and PIKFYVE in T-Cell Acute Lymphoblastic Leukemia by IKAROS and Protein Kinase CK2.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Transcriptional Regulation of PIK3CD and PIKFYVE in T-Cell Acute Lymphoblastic Leukemia by IKAROS and Protein Kinase CK2.
Prion Diseases
Loss of PIKfyve drives the spongiform degeneration in prion diseases.
Severe Acute Respiratory Syndrome
Inhibition of PIKfyve kinase prevents infection by Zaire ebolavirus and SARS-CoV-2.
Starvation
AMPK-activated ULK1 phosphorylates PIKFYVE to drive formation of PtdIns5P-containing autophagosomes during glucose starvation.
An AMPK-ULK1-PIKFYVE signaling axis for PtdIns5P-dependent autophagy regulation upon glucose starvation.
Candida glabrata STE12 is required for wild-type levels of virulence and nitrogen starvation induced filamentation.
Genomewide mechanisms of chronological longevity by dietary restriction in budding yeast.
Glucose starvation induces autophagy via ULK1-mediated activation of PIKfyve in an AMPK-dependent manner.
Phosphatidylinositol 3-phosphate 5-kinase is required for the cellular response to nutritional starvation and mating pheromone signals in Schizosaccharomyces pombe.
Regulation of mating and mating-type-specific genes in Zygosaccharomyces sp. yeast.
The STE12alpha homolog is required for haploid filamentation but largely dispensable for mating and virulence in Cryptococcus neoformans.
Thrombosis
Loss of PIKfyve in platelets causes a lysosomal disease leading to inflammation and thrombosis in mice.
Phosphatidylinositol 3 monophosphate metabolizing enzymes in blood platelet production and in thrombosis.
Tuberculosis
Trehalose limits opportunistic mycobacterial survival during HIV co-infection by reversing HIV-mediated autophagy block.
Vesicular Stomatitis
Inhibition of PIKfyve kinase prevents infection by Zaire ebolavirus and SARS-CoV-2.