2.7.1.15: ribokinase

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For detailed information about ribokinase, go to the full flat file.

Reaction

Synonyms

At1g17160, D-ribokinase, deoxyribokinase, Ms4585, rbk, RBSK, rbsK1, ribokinase, ribokinase (phosphorylating), Rv2436, Sa239

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.1 Phosphotransferases with an alcohol group as acceptor

                2.7.1.15 ribokinase

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Results	in table
5	Activating Compound
34168	AA Sequence
2	Application
1	CAS Registry Number
19	Cloned(Commentary)
11	Crystallization (Commentary)
13	Disease/ Diagnostics
2	Expression
6	General Information
41	Inhibitors
11	kcat/KM [mM/s]
9	Ki Value [mM]
43	KM Value [mM]
42	Metals/Ions
6	Molecular Weight [Da]
13	Natural Substrates/ Products (Substrates)
47	Organism
5	Pathway
113	PDB ID
6	pH Optimum
1	pH Range
6	Protein Variants
12	Purification (Commentary)
1	Reaction
4	Reaction Type
45	Reference
1	Source Tissue
4	Specific Activity [micromol/min/mg]
3	Storage Stability
66	Substrates and Products (Substrate)
5	Subunits
19	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]
2	Temperature Stability [°C]
16	Turnover Number [1/s]

Engineering

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Engineering on EC 2.7.1.15 - ribokinase

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PROTEIN VARIANTS

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

E202L

Homo sapiens

Q9H477

mutation in NXXE motif, increase in the Km for MgATP of 52fold, and a decrease in the kcat value of around 200fold

737810

N199L

Homo sapiens

Q9H477

mutation in NXXE motif, increase in the Km for MgATP- by about 68fold, a decrease in the kcat between 573- and 1036fold and almost no change in the Km for D-ribose. No substrate inhibition by D-ribose

737810

S11N/A14V

Mycobacterium tuberculosis

-

mutant shows no interaction with topoisomerase I

713968

A13/103/116V

Mycolicibacterium smegmatis

-

mutant shows no interaction with topoisomerase I. Mutant only partially retains its ability to inhibit the activity of topoisomerase I even at high protein concentrations. Topoisomerase I does not significantly stimulate the activity of the mutant protein

713968

S11N/A14V

Mycolicibacterium smegmatis

-

mutant shows no interaction with topoisomerase I. Mutant only partially retains its ability to inhibit the activity of topoisomerase I even at high protein concentrations. Topoisomerase I does not significantly stimulate the activity of the mutant protein

713968

M10N

Salmonella enterica

-

70 fold higher KM for deoxyribose but only 2 fold increased KM for ribose

641007