2.7.1.148: 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase

This is an abbreviated version!
For detailed information about 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase, go to the full flat file.

Reaction

Synonyms

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase, 4-(cytidine-5-diphospho)-2-C-methyl-D-erythritol kinase, 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, 4-diphosphocytidyl-2-C-methylerythritol 2-kinase, 4-diphosphocytidyl-2C-methyl-D-erythritol 2-kinase, 4-diphosphocytidyl-2C-methyl-D-erythritol kinase, AaIspE, BsIspE, CcCMK1, CDP-ME, CDP-ME kinase, CDP-methylerythritol kinase, CDPME kinase, CDPMEK, CMK, EcIspE, GbCMK1, GbCMK2, IspDF, IspE, More, PvIspE, Ripening-associated protein pTOM41, TwCMK, YchB

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.1 Phosphotransferases with an alcohol group as acceptor

                2.7.1.148 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase

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Results	in table
2	Activating Compound
35710	AA Sequence
5	Application
1	CAS Registry Number
13	Cloned(Commentary)
9	Cofactor
8	Crystallization (Commentary)
1	Expression
16	General Information
8	IC50 Value
19	Inhibitors
11	Ki Value [mM]
4	KM Value [mM]
5	Localization
16	Metals/Ions
6	Molecular Weight [Da]
17	Natural Substrates/ Products (Substrates)
128	Organism
7	Pathway
24	PDB ID
3	pH Optimum
4	pI Value
13	Protein Variants
10	Purification (Commentary)
5	Reaction
4	Reaction Type
27	Reference
4	Source Tissue
4	Specific Activity [micromol/min/mg]
33	Substrates and Products (Substrate)
5	Subunits
68	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]

Substrates Products

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Substrates Products on EC 2.7.1.148 - 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol + ATP

2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol + ADP

Ginkgo biloba

A6XAA8, A6XAA9

-

689692

-

-

ir

4-diphosphocytidyl-2C-methyl-D-erythritol + ATP

4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate + ADP

Aquifex aeolicus

O67060

non-mevalonate pathway of isoprenoid precursor synthesis

686699

-

-

ir

ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

22 entries

additional information

?

-

5 entries

ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

Bacillus subtilis

P37550

-

747328

-

-

?

ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

Bacillus subtilis 168

P37550

-

747328

-

-

?

ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

Bacillus subtilis DSM 23778

P37550

-

747328

-

-

?

ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

Cinnamomum camphora

A0A1J0I9Y0

-

762521

-

-

?

ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

Escherichia coli

-

-

349729, 673095, 699633, 721831

-

-

?

ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

Escherichia coli

P62615

-

721187, 747328

-

-

?

ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

Escherichia coli

-

fourth reaction step of the 2-C-methyl-D-erythritol 4-phosphate pathway

660700

-

-

?

ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

Escherichia coli

-

the enzyme is essential in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis

663207

-

-

?

ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

Escherichia coli

-

i.e. CDP-ME

660700, 663207

-

-

?

ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

Escherichia coli

-

non-mevalonate pathway for isoprenoid biosynthesis

673095

-

-

?

ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

Escherichia coli DH5-alpha

-

-

721831

-

-

?

ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

Mycobacterium tuberculosis

P9WKG7

-

722218

-

-

?

ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

Mycobacterium tuberculosis H37Rv

P9WKG7

-

722218

-

-

?

ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

Plasmodium vivax

A5KAU8

-

762094

-

-

?

ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

Plasmodium vivax Salvador I

A5KAU8

-

762094

-

-

?

ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

Solanum lycopersicum

P93841

-

349728

-

-

?

ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

Solanum lycopersicum

P93841

involved in terpenoid biosynthesis via deoxyxylulose phosphate pathway

349728

-

-

?

ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

Thermus thermophilus

-

the enzyme is essential in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis, pathway overview

662149

-

-

?

ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

Thermus thermophilus

-

i.e. CDP-ME, the cytosine group plays an essential role in substrate recognition by the enzyme

662149

-

-

?

ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

Thermus thermophilus HB8 / ATCC 27634 / DSM 579

-

the enzyme is essential in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis, pathway overview

662149

-

-

?

ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

Thermus thermophilus HB8 / ATCC 27634 / DSM 579

-

i.e. CDP-ME, the cytosine group plays an essential role in substrate recognition by the enzyme

662149

-

-

?

ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

Yersinia pestis

-

-

721831

-

-

?

additional information

?

-

Agrobacterium tumefaciens

-

in Agrobacterium tumefaciens the ispD and ispF genes are fused to encode a bifunctional enzyme that catalyzes the first (synthesis of 4-diphosphocytidyl-2-C-methyl D-erythritol) and third (synthesis of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate) steps of isoprenoid biosynthetic pathway. Enzyme-generated intermediates are not transferred from the IspD active site in IspDF to the active site of IspE or from the active site in IspE to the active site of the IspF module of IspDF

672138

-

-

?

additional information

?

-

Solanum lycopersicum

P93841

no conversion of isopentenyl phosphate into isopentenyl diphosphate

349728

-

-

?

additional information

?

-

Solanum lycopersicum

-

no conversion of isopentenyl phosphate into isopentenyl diphosphate

349728

-

-

?

additional information

?

-

Thermus thermophilus

-

no activity with 4-(adenine 5'-phosphate)-2-C-methyl-D-erythritol and 4-(uridine 5'-phosphate)-2-C-methyl-D-erythritol

662149

-

-

?

additional information

?

-

Thermus thermophilus HB8 / ATCC 27634 / DSM 579

-

no activity with 4-(adenine 5'-phosphate)-2-C-methyl-D-erythritol and 4-(uridine 5'-phosphate)-2-C-methyl-D-erythritol

662149

-

-

?