2.7.1.148: 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase

This is an abbreviated version!
For detailed information about 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase, go to the full flat file.

Word Map on EC 2.7.1.148

2.7.1.148

isoprenoids

mevalonate

isopentenyl

malaria

2-phosphate

antimalarial

dimethylallyl

plasmodium

non-mevalonate

jasmonate

drug development

1-deoxy-d-xylulose

terpenoids

nonhydrolyzable

solvent-mediated

mevalonate-independent

gametocytic

apicomplexan

water-mediated

2,4-cyclodiphosphate

2-hydroxyl

dmapp

medicine

Reaction

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

Synonyms

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase, 4-(cytidine-5-diphospho)-2-C-methyl-D-erythritol kinase, 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, 4-diphosphocytidyl-2-C-methylerythritol 2-kinase, 4-diphosphocytidyl-2C-methyl-D-erythritol 2-kinase, 4-diphosphocytidyl-2C-methyl-D-erythritol kinase, AaIspE, BsIspE, CcCMK1, CDP-ME, CDP-ME kinase, CDP-methylerythritol kinase, CDPME kinase, CDPMEK, CMK, EcIspE, GbCMK1, GbCMK2, IspDF, IspE, More, PvIspE, Ripening-associated protein pTOM41, TwCMK, YchB

ECTree

2 Transferases

2.7 Transferring phosphorus-containing groups

2.7.1 Phosphotransferases with an alcohol group as acceptor

2.7.1.148 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase

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Results	in table
2	Activating Compound
35710	AA Sequence
5	Application
1	CAS Registry Number
13	Cloned(Commentary)
9	Cofactor
8	Crystallization (Commentary)
1	Expression
16	General Information
8	IC50 Value
19	Inhibitors
11	Ki Value [mM]
4	KM Value [mM]
5	Localization
16	Metals/Ions
6	Molecular Weight [Da]
17	Natural Substrates/ Products (Substrates)
128	Organism
7	Pathway
24	PDB ID
3	pH Optimum
4	pI Value
13	Protein Variants
10	Purification (Commentary)
5	Reaction
4	Reaction Type
27	Reference
4	Source Tissue
4	Specific Activity [micromol/min/mg]
33	Substrates and Products (Substrate)
5	Subunits
68	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]

Natural Substrates Products

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Natural Substrates Products on EC 2.7.1.148 - 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase

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4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol + ATP

2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol + ADP

Ginkgo biloba

A6XAA8, A6XAA9

689692

4-diphosphocytidyl-2C-methyl-D-erythritol + ATP

4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate + ADP

Aquifex aeolicus

O67060

non-mevalonate pathway of isoprenoid precursor synthesis

686699

ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

14 entries

additional information

Agrobacterium tumefaciens

in Agrobacterium tumefaciens the ispD and ispF genes are fused to encode a bifunctional enzyme that catalyzes the first (synthesis of 4-diphosphocytidyl-2-C-methyl D-erythritol) and third (synthesis of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate) steps of isoprenoid biosynthetic pathway. Enzyme-generated intermediates are not transferred from the IspD active site in IspDF to the active site of IspE or from the active site in IspE to the active site of the IspF module of IspDF

672138