2.7.1.148: 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase
This is an abbreviated version!
For detailed information about 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase, go to the full flat file.
Word Map on EC 2.7.1.148
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2.7.1.148
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isoprenoids
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mevalonate
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isopentenyl
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malaria
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2-phosphate
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antimalarial
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dimethylallyl
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plasmodium
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non-mevalonate
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jasmonate
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drug development
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1-deoxy-d-xylulose
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terpenoids
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nonhydrolyzable
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solvent-mediated
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mevalonate-independent
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gametocytic
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apicomplexan
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water-mediated
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2,4-cyclodiphosphate
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2-hydroxyl
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dmapp
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medicine
- 2.7.1.148
-
isoprenoids
- mevalonate
-
isopentenyl
- malaria
- 2-phosphate
-
antimalarial
-
dimethylallyl
- plasmodium
-
non-mevalonate
- jasmonate
- drug development
- 1-deoxy-d-xylulose
-
terpenoids
-
nonhydrolyzable
-
solvent-mediated
-
mevalonate-independent
-
gametocytic
-
apicomplexan
-
water-mediated
-
2,4-cyclodiphosphate
-
2-hydroxyl
-
dmapp
- medicine
Reaction
Synonyms
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase, 4-(cytidine-5-diphospho)-2-C-methyl-D-erythritol kinase, 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, 4-diphosphocytidyl-2-C-methylerythritol 2-kinase, 4-diphosphocytidyl-2C-methyl-D-erythritol 2-kinase, 4-diphosphocytidyl-2C-methyl-D-erythritol kinase, AaIspE, BsIspE, CcCMK1, CDP-ME, CDP-ME kinase, CDP-methylerythritol kinase, CDPME kinase, CDPMEK, CMK, EcIspE, GbCMK1, GbCMK2, IspDF, IspE, More, PvIspE, Ripening-associated protein pTOM41, TwCMK, YchB
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Engineering
Engineering on EC 2.7.1.148 - 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase
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additional information
two non-synonymous mutations at codons 382 (A->T) and 492 (K->T) are found in all the isolates of Delhi, Chennai, Nadiad, Sonapur Goa, and Mangaluru. Apart from these, two more mutations are observed in all the isolates of Goa and Mangaluru namely one substitution at codon 351(T->M) and another synonymous mutation at codon 344 (S) TCT->TCC. In Rourkela which is one of the highly malaria endemic and isolated tribal regions of India, four non-synonymous mutations at codons 336 (R->S), 351 (T->M), 402 (G->R) and 405 (L->Q) are detected in all isolates. Domain architecture and mutation mapping, overview
additional information
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two non-synonymous mutations at codons 382 (A->T) and 492 (K->T) are found in all the isolates of Delhi, Chennai, Nadiad, Sonapur Goa, and Mangaluru. Apart from these, two more mutations are observed in all the isolates of Goa and Mangaluru namely one substitution at codon 351(T->M) and another synonymous mutation at codon 344 (S) TCT->TCC. In Rourkela which is one of the highly malaria endemic and isolated tribal regions of India, four non-synonymous mutations at codons 336 (R->S), 351 (T->M), 402 (G->R) and 405 (L->Q) are detected in all isolates. Domain architecture and mutation mapping, overview
additional information
-
two non-synonymous mutations at codons 382 (A->T) and 492 (K->T) are found in all the isolates of Delhi, Chennai, Nadiad, Sonapur Goa, and Mangaluru. Apart from these, two more mutations are observed in all the isolates of Goa and Mangaluru namely one substitution at codon 351(T->M) and another synonymous mutation at codon 344 (S) TCT->TCC. In Rourkela which is one of the highly malaria endemic and isolated tribal regions of India, four non-synonymous mutations at codons 336 (R->S), 351 (T->M), 402 (G->R) and 405 (L->Q) are detected in all isolates. Domain architecture and mutation mapping, overview
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